Tolmetin sodium
- CAS No.
- 35711-34-3
- Chemical Name:
- Tolmetin sodium
- Synonyms
- TOLECTIN;Sodium tolmetin;TOLMETIN SODIUM;TOLMETIN SODIUM USP;Tolmetin Sodium Salt;Tolmetin sodium USP/EP/BP;sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate;sodium:2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate;1-Methyl-5-p-toluoyl-1H-pyrrole-2-acetic acid sodium salt;1-Methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid sodium salt
- CBNumber:
- CB6397353
- Molecular Formula:
- C15H14NNaO3
- Molecular Weight:
- 279.27
- MDL Number:
- MFCD00079607
- MOL File:
- 35711-34-3.mol
- MSDS File:
- SDS
| FDA UNII | WL259637KX |
|---|
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
Tolmetin sodium price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD11136393 | Sodium 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate 95+% | 35711-34-3 | 1g | $614 | 2026-05-26 | Buy |
| Chemenu | CM157215 | sodium 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate 95% | 35711-34-3 | 1g | $580 | 2026-05-26 | Buy |
| Abosyn | 22-0655 | Tolmetin sodium ＞95%(Puritymayvarybetweenbatches) | 35711-34-3 | 1g | $1840 | 2026-05-21 | Buy |
| TRC | T535375 | Tolmetin sodium | 35711-34-3 | 25mg | $165 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0016245 | TOLMETIN SODIUM 95.00% | 35711-34-3 | 5MG | $502.11 | 2021-12-16 | Buy |
Tolmetin sodium Chemical Properties,Uses,Production
Originator
Tolectin,McNeil,US,1976
Uses
Tolectin (Ortho-McNeil).
Uses
Tolmetin Sodium is a non-steroidal anti-inflammatory drug.
Definition
ChEBI: Tolmetin sodium is an organic sodium salt that is the monosodium salt of tolmetin. Used in the form of its dihydrate as a nonselective nonsteroidal anti-inflammatory drug. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a non-steroidal anti-inflammatory drug. It contains a tolmetin(1-).
Manufacturing Process
5-(p-Toluoyl)-1-methylpyrrole-2-acetonitrile - To a cooled suspension of 26.6 g
(0.2 mol) aluminum chloride in 80 ml dichloroethane is added dropwise 30.8 g
(0.2 mol) p-toluoyl chloride. The resulting solution is added dropwise to a
solution of 1-methylpyrrole-2-acetonitrile in 80 ml dichloroethane cooled
externally with an ice bath. After the addition, the resulting solution is stirred
at room temperature for 20 minutes and then refluxed for 3 minutes. The
solution is poured into ice acidified with dilute hydrochloric acid. The organic
and aqueous fractions are separated. The aqueous fraction is extracted once
with chloroform.
The organic fractions are combined and washed successively with N,N_x0002_dimethyl-1,3-propanediamine, dilute hydrochloric acid, saturated sodium
bicarbonate solution and saturated sodium chloride solution. The organic
fraction is dried over anhydrous magnesium sulfate. The solvent is then
evaporated off. Upon trituration of the residue with methanol, a solid
crystallizes, 5-(p-toluoyl)-1-methylpyrrole-2-acetonitrile, which is removed by
filtration and purified by recrystallization from benzene.
Additional product is isolated from the mother liquors which are combined,
concentrated in vacuo and the resulting oily residue column chromatographed
on neutral alumina using hexane, benzene and ether as successive solvents.
The product is isolated by concentrating in vacuo the first few major
compound-bearing fractions (10% ether in benzene). The solids are combined
and recrystallized from methanol and then from benzene-hexane, melting
point 102°C to 105°C.
5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid - A solution of 3.67 g (0.015 mol)
of 5-(p-toluoyl)-1-methylpyrrole-2-acetonitrile, 24 ml of 1 N sodium hydroxide
and 50 ml of 95% ethanol is stirred and refluxed for 24 hours.
The resulting solution is poured into ice acidified with dilute hydrochloric acid.
A white solid precipitates which is extracted into ether. The ether phase is
washed with a saturated solution of sodium chloride and dried over anhydrous
magnesium sulfate. The solvent is evaporated and a white solid, 5-(p-toluoyl)-
1-methylpyrrole-2-acetic acid is obtained which is recrystallized twice from
isopropanol, melting point 155°C to 157°C.
Therapeutic Function
Antiinflammatory
Pharmacokinetics
Tolmetin sodium is rapidly and almost completely absorbed on oral administration, with peak plasma levels being attained within the first hour of administration. It has a relatively short plasma half-life of approximately 1 hour because of extensive first-pass metabolism, involving hydroxylation of the p-methyl group to the primary alcohol, which is subsequently oxidized to the dicarboxylic acid.
Clinical Use
Tolmetin is synthesized straightforwardly from 1-methylpyrrole. It was introduced in the United States in 1976 and like other NSAIDs, inhibits prostaglandin biosynthesis. Tolmetin, however, also inhibits polymorph migration and decreases capillary permeability. Its anti-inflammatory activity, as measured in the carrageenan-induced rat paw edema and cotton pellet granuloma assays, is intermediate between those of phenylbutazone and indomethacin.
Side effects
The most frequently adverse reactions are those involving the GI tract (e.g., abdominal pain, discomfort, and nausea) but appear to be less than those observed with aspirin. The CNS effects (e.g., dizziness and drowsiness) also are observed. Few cases of overdosage have been reported, but in such cases, recommended treatment includes elimination of the drug from the GI tract by emesis or gastric lavage and elimination of the acidic drug from the circulatory system by enhancing alkalinization of the urine with sodium bicarbonate.
Metabolism
This metabolite is inactive in standard in vivo anti-inflammatory assays. The free acid (pKa = 3.5) is highly bound to plasma proteins (99%), and excretion of tolmetin and its metabolites occurs primarily in the urine.Approximately 15 to 20% of an administered dose is excreted unchanged and 10% as the glucuronide conjugate of the parent drug. Conjugates of the dicarboxylic acid metabolite account for the majority of the remaining administered drug.
Tolmetin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Tolmetin sodium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| Wellman Pharmaceutical Group Limited | 15807197853 18971451745 | 15807197853@163.com | China | 3968 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29091 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Hubei widely chemical technology Co., Ltd. | 027-83989310 18627915365 | 2658488909@qq.com | China | 1143 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Wuhan Xinyang Ruihe Chemical Technology Co., Ltd. | 13720181483 13720181483 | 366443693@QQ.COM | China | 994 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-81120477 17792793610 | 1033@dideu.com | China | 9990 | 58 |
View Lastest Price from Tolmetin sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Tolmetin sodium USP/EP/BP
35711-34-3
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-04-21 | Tolmetin sodium
35711-34-3
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Tolmetin sodium USP/EP/BP
35711-34-3
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Tolmetin sodium
35711-34-3
- $1520.00-2500.00
- TargetMol Chemicals Inc.
