4-(Trifluoromethoxy)benzoic acid
- CAS No.
- 330-12-1
- Chemical Name:
- 4-(Trifluoromethoxy)benzoic acid
- Synonyms
- AKOS BBS-00006470;RARECHEM AL BO 0419;TIMTEC-BB SBB000455;uoromethoxy)benzoic Acid;a,a,a-trifluoro-p-anisic acid;P-TRIFLUOROMETHOXYBENZOIC ACID;Anti-Trifluoroxide Benzoic Acids;4-(TRIFLUOROMETHOXY)BENZOIC ACID;For trifluoromethoxy benzoic acid;4-TRIFLUOROMETHOXYBENZOIC ACID-D4
- CBNumber:
- CB6403100
- Molecular Formula:
- C8H5F3O3
- Molecular Weight:
- 206.12
- MDL Number:
- MFCD00002541
- MOL File:
- 330-12-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(Trifluoromethoxy)benzoic acid 96% | 301396 | 1g | $42 |
| 4-(Trifluoromethoxy)benzoic Acid >97.0%(GC)(T) | T1400 | 1g | $27 |
| 4-(Trifluoromethoxy)benzoic Acid min. 97.0 % | T1400 | 25G | $231 |
| 4-(Trifluoromethoxy)benzoic Acid >97.0%(GC)(T) | T1400 | 5g | $77 |
| 4-(Trifluoromethoxy)benzoic Acid | T790720 | 5g | $130 |
| More product size | |||
| Melting point | 150-154 °C(lit.) |
|---|---|
| Boiling point | 203°C (rough estimate) |
| Density | 1.4251 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| pka | 3.85±0.10(Predicted) |
| form | Powder |
| color | White to cream |
| BRN | 977356 |
| InChI | InChI=1S/C8H5F3O3/c9-8(10,11)14-6-3-1-5(2-4-6)7(12)13/h1-4H,(H,12,13) |
| InChIKey | RATSANVPHHXDCT-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(OC(F)(F)F)C=C1 |
| CAS DataBase Reference | 330-12-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-(Trifluoromethoxy)benzoic acid(330-12-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-(Trifluoromethoxy)benzoic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 301396 | 4-(Trifluoromethoxy)benzoic acid 96% | 330-12-1 | 1g | $42 | 2022-05-15 | Buy |
| TCI Chemical | T1400 | 4-(Trifluoromethoxy)benzoic Acid >97.0%(GC)(T) | 330-12-1 | 1g | $27 | 2026-03-19 | Buy |
| TCI Chemical | T1400 | 4-(Trifluoromethoxy)benzoic Acid min. 97.0 % | 330-12-1 | 25G | $231 | 2026-03-19 | Buy |
| TCI Chemical | T1400 | 4-(Trifluoromethoxy)benzoic Acid >97.0%(GC)(T) | 330-12-1 | 5g | $77 | 2026-03-19 | Buy |
| TRC | T790720 | 4-(Trifluoromethoxy)benzoic Acid | 330-12-1 | 5g | $130 | 2021-12-16 | Buy |
4-(Trifluoromethoxy)benzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-(Trifluoromethoxy)benzoic Acid is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.
General Description
Kinetics of internal acyl migration and hydrolysis of the synthetic β-1-O-acyl-D-glucopyranuronates of 2-, 3-, and 4-(trifluoromethyl)benzoic acids in phosphate buffer was studied.
Synthesis
332-25-2
330-12-1
Synthesis of 4-(trifluoromethoxy)benzoic acid: 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) was dissolved in acetic acid (12 mL), and water (12 mL) and concentrated sulfuric acid (12 mL) were added sequentially. The reaction mixture was stirred and reacted at 120 °C overnight. Upon completion of the reaction, water (100 mL) was added to the mixture and the aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound 4-(trifluoromethoxy)benzoic acid (4.8 g, 98% yield) as a white solid.
References
[1] Patent: US2007/270434, 2007, A1. Location in patent: Page/Page column 16-17
4-(Trifluoromethoxy)benzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29826 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 4-(Trifluoromethoxy)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-(Trifluoromethoxy)benzoic acid
330-12-1
|
US $1.00 / KG | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- 4-(Trifluoromethoxy)benzoic acid
330-12-1
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
330-12-1(4-(Trifluoromethoxy)benzoic acid)Related Search:
1of4
