1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
- CAS No.
- 79547-78-7
- Chemical Name:
- 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
- Synonyms
- 547;R50547;LEVOSTIN;LIVOSTIN;LEVOPHTA;Unii-124xma6yei;LEVOCABASTINE HCL;(3S,4R)-Cabastine;LIVOSTIN USP/EP/BP;(3S,4R)-Cabastine HCl
- CBNumber:
- CB6411376
- Molecular Formula:
- C26H30ClFN2O2
- Molecular Weight:
- 456.99
- MDL Number:
- MFCD07787408
- MOL File:
- 79547-78-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Levocabastine for system suitability 2 European Pharmacopoeia (EP) Reference Standard | Y0001637 | 5.005 mg | $164 |
| Levocabastine Hydrochloride certified reference material, pharmaceutical secondary standard | PHR3458 | 100 mg | $325 |
| Levocabastine hydrochloride European Pharmacopoeia (EP) Reference Standard | L0390000 | 125 mg | $241 |
| Levocabastine hydrochloride United States Pharmacopeia (USP) Reference Standard | 1359856 | 50mg | $326 |
| Levocabastine Hydrochloride certified reference material, pharmaceutical secondary standard | PHR3458 | 1 unit | $300 |
| More product size | |||
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Properties
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: ~10 mg/mL, soluble |
| form | solid |
| color | white |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | OICFWWJHIMKBCD-VALQNVSPSA-N |
| SMILES | Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4 |
| FDA UNII | 124XMA6YEI |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001637 | Levocabastine for system suitability 2 European Pharmacopoeia (EP) Reference Standard | 79547-78-7 | 5.005 mg | $164 | 2026-03-19 | Buy |
| Sigma-Aldrich | PHR3458 | Levocabastine Hydrochloride certified reference material, pharmaceutical secondary standard | 79547-78-7 | 100 mg | $325 | 2026-03-19 | Buy |
| Sigma-Aldrich | L0390000 | Levocabastine hydrochloride European Pharmacopoeia (EP) Reference Standard | 79547-78-7 | 125 mg | $241 | 2026-03-19 | Buy |
| Sigma-Aldrich | 1359856 | Levocabastine hydrochloride United States Pharmacopeia (USP) Reference Standard | 79547-78-7 | 50mg | $326 | 2026-03-19 | Buy |
| Sigma-Aldrich | PHR3458 | Levocabastine Hydrochloride certified reference material, pharmaceutical secondary standard | 79547-78-7 | 1 unit | $300 | 2025-07-31 | Buy |
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Chemical Properties,Uses,Production
Description
Levocabastine hydrochloride is a new, highly potent and specific histamine HI-receptor antagonist without anticholinergic or antiserotonergic side effects. It is reported to have both a fast onset and long duration of action. Indications are the treatment of allergic conjunctivitis and allergic rhinitis.
Chemical Properties
White or almost white powder.
Originator
Janssen (Johnson & Johnson) (U.S.A.)
Uses
A histamine H1 receptor antagonist used in allergic conjunctivitis.
Definition
ChEBI: Livostin (TN) is a member of piperidines.
Manufacturing Process
4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)
brand name
Livostin (Novartis).
Therapeutic Function
Antihistaminic
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 5945 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Guangzhou CATO Research Chemicals Inc. | +86-020-81960175-617 +8615602392859 | Intermediate@cato-chem.com | China | 3858 | 58 |
View Lastest Price from 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Levocabastine hydrochloride
79547-78-7
|
US $420.00-113.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-12-16 | Levocabastine hydrochloride
79547-78-7
|
US $0.00-0.00 / mg | 10mg | 95%+ | 100000 | Moxin Chemicals | |
 |
2025-11-18 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP
79547-78-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Levocabastine hydrochloride
79547-78-7
- US $420.00-113.00 / mg
- TargetMol Chemicals Inc.
-
- Levocabastine hydrochloride
79547-78-7
- US $0.00-0.00 / mg
- 95%+
- Moxin Chemicals
-
- 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP
79547-78-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
79547-78-7(1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride)Related Search:
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