1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
- CAS No.
- 79547-78-7
- Chemical Name:
- 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
- Synonyms
- 547;R50547;LEVOSTIN;LIVOSTIN;LEVOPHTA;Unii-124xma6yei;LEVOCABASTINE HCL;(3S,4R)-Cabastine;LIVOSTIN USP/EP/BP;(3S,4R)-Cabastine HCl
- CBNumber:
- CB6411376
- Molecular Formula:
- C26H30ClFN2O2
- Molecular Weight:
- 456.99
- MDL Number:
- MFCD07787408
- MOL File:
- 79547-78-7.mol
- MSDS File:
- SDS
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Properties
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: ~10 mg/mL, soluble |
| form | solid |
| color | white |
| FDA UNII | 124XMA6YEI |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399090 | |||||||||
| NFPA 704 |
|
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001637 | Levocabastine for system suitability 2 European Pharmacopoeia (EP) Reference Standard | 79547-78-7 | 5.005 mg | $153 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHR3458 | Levocabastine Hydrochloride certified reference material, pharmaceutical secondary standard | 79547-78-7 | 1 unit | $300 | 2025-07-31 | Buy |
| Sigma-Aldrich | L0390000 | Levocabastine hydrochloride European Pharmacopoeia (EP) Reference Standard | 79547-78-7 | 125 mg | $225 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1359856 | Levocabastine hydrochloride United States Pharmacopeia (USP) Reference Standard | 79547-78-7 | 50mg | $304 | 2025-07-31 | Buy |
| Sigma-Aldrich | L3042 | Levocabastine hydrochloride ≥99% (HPLC), solid | 79547-78-7 | 5mg | $255 | 2023-06-20 | Buy |
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Chemical Properties,Uses,Production
Description
Levocabastine hydrochloride is a new, highly potent and specific histamine HI-receptor antagonist without anticholinergic or antiserotonergic side effects. It is reported to have both a fast onset and long duration of action. Indications are the treatment of allergic conjunctivitis and allergic rhinitis.
Chemical Properties
White or almost white powder.
Originator
Janssen (Johnson & Johnson) (U.S.A.)
Uses
A histamine H1 receptor antagonist used in allergic conjunctivitis.
Definition
ChEBI: Livostin (TN) is a member of piperidines.
Manufacturing Process
4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)
brand name
Livostin (Novartis).
Therapeutic Function
Antihistaminic
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20503 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 5949 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Guangzhou CATO Research Chemicals Inc. | +86-020-81960175-617 +8615602392859 | Intermediate@cato-chem.com | China | 3861 | 58 |
View Lastest Price from 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-31 | Levocabastine hydrochloride
79547-78-7
|
US $0.00-0.00 / mg | 10mg | 95%+ | 100000 | Moxin Chemicals | |
 |
2025-07-26 | Levocabastine hydrochloride
79547-78-7
|
US $0.00-0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2021-07-27 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP
79547-78-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Levocabastine hydrochloride
79547-78-7
- US $0.00-0.00 / mg
- 95%+
- Moxin Chemicals
-
- Levocabastine hydrochloride
79547-78-7
- US $0.00-0.00 / mg
- TargetMol Chemicals Inc.
-
- 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP
79547-78-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
79547-78-7(1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride)Related Search:
1of4
