1-Aminocyclobutanecarboxylic acid
- CAS No.
- 22264-50-2
- Chemical Name:
- 1-Aminocyclobutanecarboxylic acid
- Synonyms
- 1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID;ACBC;cb1700;AC4C-OH;ACBC-OH;cVal-OH;1,1-ACCB;1-Aminocyclobutaneca;1-Amino-1-carboxycyclobutane;1-amino-cyclobutanecarboxylicaci
- CBNumber:
- CB6419246
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD00661068
- MOL File:
- 22264-50-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Amino-1-cyclobutanecarboxylic acid 97% | 652369 | 1g | $60.57 |
| 1-Amino-1-cyclobutanecarboxylic acid 97% | 652369 | 5g | $185 |
| 1-Aminocyclobutane-1-carboxylic Acid | A3638 | 1G | $36 |
| 1-Aminocyclobutane-1-carboxylic Acid | A3638 | 5G | $108 |
| ACBC | 254526 | 25mg | $366 |
| More product size | |||
| Melting point | 261 °C (dec.)(lit.) |
|---|---|
| Boiling point | 241.1±23.0 °C(Predicted) |
| Density | 1.290±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.38±0.20(Predicted) |
| form | Powder |
| color | White |
| Water Solubility | Soluble to 100 mM in water. |
| InChI | InChI=1S/C5H9NO2/c6-5(4(7)8)2-1-3-5/h1-3,6H2,(H,7,8) |
| InChIKey | FVTVMQPGKVHSEY-UHFFFAOYSA-N |
| SMILES | C1(N)(C(O)=O)CCC1 |
| CAS DataBase Reference | 22264-50-2(CAS DataBase Reference) |
| FDA UNII | 1K1PGC7J6Z |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GU1336000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
1-Aminocyclobutanecarboxylic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 652369 | 1-Amino-1-cyclobutanecarboxylic acid 97% | 22264-50-2 | 1g | $60.57 | 2025-07-31 | Buy |
| Sigma-Aldrich | 652369 | 1-Amino-1-cyclobutanecarboxylic acid 97% | 22264-50-2 | 5g | $185 | 2023-06-20 | Buy |
| TCI Chemical | A3638 | 1-Aminocyclobutane-1-carboxylic Acid | 22264-50-2 | 1G | $36 | 2025-07-31 | Buy |
| TCI Chemical | A3638 | 1-Aminocyclobutane-1-carboxylic Acid | 22264-50-2 | 5G | $108 | 2025-07-31 | Buy |
| Usbiological | 254526 | ACBC | 22264-50-2 | 25mg | $366 | 2021-12-16 | Buy |
1-Aminocyclobutanecarboxylic acid Chemical Properties,Uses,Production
Uses
1-Aminocyclobutanecarboxylic acid acts as an agonist being an analog of glycine at the NMDA-glycine receptor site. This affects the signal transmission in the CNS.
Uses
ACBC is an NMDA receptor antagonist acting at the glycine site. It acts as an agonist being an analog of glycine at the NMDA-glycine receptor site. This affects the signal transmission in the CNS.
Definition
ChEBI: 1-AMINOCYCLOBUTANE CARBOXYLIC ACID is a L-alpha-amino acid.
reaction suitability
reaction type: solution phase peptide synthesis
Biological Activity
NMDA receptor antagonist acting at the glycine site.
Synthesis
845621-11-6
22264-50-2
1. 1-carbamoyl-cyclobutanecarboxylic acid (1.43 g, 10.0 mmol, 1 eq.) was dissolved in a water-ice bath under nitrogen protection and 1N aqueous NaOH solution (10 mL, 10.0 mmol, 1 eq.) was added slowly. 2. NaOCl solution (10-13% solution, 9.0 mL, ~15.0 mmol, 1.5 eq.) was added slowly and the reaction mixture was stirred for 1 hour at 5 °C. 3. 10N NaOH solution (2.0 mL, 20 mmol, 2 eq.) was added slowly, keeping the reaction temperature below 20 °C and stirred at 15-25 °C for 3 h. The reaction was monitored by LC-MS. The completion of the reaction was monitored by LC-MS. 4. Quench the reaction with an aqueous solution (3 mL) of Na2S2O3-3H2O (2.48 g, 10 mmol, 1 eq.) at 15 °C and continue stirring for 1 hour. 5. Neutralize the reaction mixture with 12N HCl aqueous solution to pH=7.0. 6. Volatiles were removed by azeotropic distillation with toluene under reduced pressure to give about 9 g of white solid. 7. The solid was extracted with methanol (3 x 30 mL) and 2.0 g of crude product was obtained after evaporation of methanol. 8. By 1H NMR analysis, it was determined that the solid contained 0.81 g of the target product, 1-aminocyclobutanecarboxylic acid (70% yield), and the rest were inorganic salts. 9. Comparison of 1H and 13C NMR data confirmed that the structure of the product was consistent with the standard sample provided by Sumitomo Chemical, Inc.
storage
Room temperature
References
[1] Patent: WO2005/19158, 2005, A1. Location in patent: Page/Page column 18
1-Aminocyclobutanecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20175 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13451 | 58 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 925 | 55 |
| AB PharmaTech,LLC | 323-480-4688 | sales@acrospharmatech.com | United States | 989 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
View Lastest Price from 1-Aminocyclobutanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-19 | 1-Aminocyclobutanecarboxylic acid
22264-50-2
|
US $73.00-48.00 / mg | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-25 | 1-Aminocyclobutanecarboxylic acid
22264-50-2
|
US $3.00-0.20 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-07-02 | 1-Amino-1-cyclobutanecarboxylic acid
22264-50-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1-Aminocyclobutanecarboxylic acid
22264-50-2
- US $73.00-48.00 / mg
- 99.94%
- TargetMol Chemicals Inc.
-
- 1-Aminocyclobutanecarboxylic acid
22264-50-2
- US $3.00-0.20 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 1-Amino-1-cyclobutanecarboxylic acid
22264-50-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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