Isoflupredone
- CAS No.
- 338-95-4
- Chemical Name:
- Isoflupredone
- Synonyms
- 9-FLUOROPREDNISOLONE;NSC 12174;ISOFLUPREDONE;DELTAFLUDROCORTISONE;9α-Fluoro-1-cortisol;9a-fluoroprednisolone;9α-Fluoroprednisolone;Isoflupredone USP/EP/BP;Isoflupredone in Methanol;9-ALPHA-FLUOROPREDNISOLONE
- CBNumber:
- CB6440732
- Molecular Formula:
- C21H27FO5
- Molecular Weight:
- 378.43
- MDL Number:
- MFCD00076089
- MOL File:
- 338-95-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Isoflupredone | I816600 | 10mg | $180 |
| ISOFLUPREDONE 95.00% | SHG0006926 | 1MG | $739.2 |
| ISOFLUPREDONE 95.00% | SHG0006926 | 10MG | $1871.1 |
| More product size | |||
| Melting point | 260-262°C (dec.) |
|---|---|
| alpha | D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried) |
| Boiling point | 566.7±50.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly) |
| pka | 12.10±0.70(Predicted) |
| form | Solid |
| color | White to Pale Brown |
| InChIKey | WAIJIHDWAKJCBX-MPVZUUJONA-N |
| SMILES | [C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)CO |&1:0,10,12,14,17,19,22,r| |
| FDA UNII | HYS0B45Z2S |
Isoflupredone price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I816600 | Isoflupredone | 338-95-4 | 10mg | $180 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0006926 | ISOFLUPREDONE 95.00% | 338-95-4 | 1MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0006926 | ISOFLUPREDONE 95.00% | 338-95-4 | 10MG | $1871.1 | 2021-12-16 | Buy |
Isoflupredone Chemical Properties,Uses,Production
Description
Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1].
Chemical Properties
White Solid
Originator
Isoflupredon,Farmabios
Uses
Isoflupredone is an anti-inflammatory. Isoflupredone could be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3].
Definition
ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid.
Manufacturing Process
A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml
of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml
Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of
Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for
24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α-
fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated
with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The
culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
The product is extracted with chloroform and isolated by evaporation to
dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene-
11β,17α,21-triol-3.20-dione as a solid.
Therapeutic Function
Glucocorticoid
References
[1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
[2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
[3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512.
Isoflupredone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9731 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 9996 | 58 |
View Lastest Price from Isoflupredone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-13 | Isoflupredone
338-95-4
|
US $34.00-148.00 / mg | 99.60% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-17 | 9-fluoroprednisolone
338-95-4
|
US $20.00-10.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-17 | 9-fluoroprednisolone
338-95-4
|
US $9.00-60.00 / g | 10g | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD |
-
- Isoflupredone
338-95-4
- US $34.00-148.00 / mg
- 99.60%
- TargetMol Chemicals Inc.
-
- 9-fluoroprednisolone
338-95-4
- US $20.00-10.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD
-
- 9-fluoroprednisolone
338-95-4
- US $9.00-60.00 / g
- 99%
- Hebei Kangcang new material Technology Co., LTD
