3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
![3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER Structure](CAS/GIF/34761-09-6.gif)
- CAS No.
- 34761-09-6
- Chemical Name:
- 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- AKOS 92613;ethyl 3-aminobenzothiophene-2-carboxylate;Ethyl 3-amino-1-benzothiophene-2-carboxylate;3-aminobenzothiophene-2-carboxylic acid ethyl ester;3-amino-2-benzothiophenecarboxylic acid ethyl ester;3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER;Benzo[b]thiophene-2-carboxylic acid, 3-amino-, ethyl ester;1-(3-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxylic Acid
- CBNumber:
- CB6445616
- Molecular Formula:
- C11H11NO2S
- Molecular Weight:
- 221.28
- MDL Number:
- MFCD00661903
- MOL File:
- 34761-09-6.mol
- MSDS File:
- SDS
| Melting point | ca 82℃ subl. |
|---|---|
| Boiling point | 373.4±22.0 °C(Predicted) |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 0.83±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C11H11NO2S/c1-2-14-11(13)10-9(12)7-5-3-4-6-8(7)15-10/h3-6H,2,12H2,1H3 |
| InChIKey | XZSFZYVMRZLUOJ-UHFFFAOYSA-N |
| SMILES | C12=CC=CC=C1C(N)=C(C(OCC)=O)S2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F590620 | 1-(3-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxylicAcid | 34761-09-6 | 10mg | $45 | 2021-12-16 | Buy |
| SynQuest Laboratories | 8H58-1-0C | Ethyl 3-amino-1-benzothiophene-2-carboxylate | 34761-09-6 | 5G | $101 | 2021-12-16 | Buy |
| Matrix Scientific | 080313 | Ethyl 3-amino-1-benzothiophene-2-carboxylate | 34761-09-6 | 500mg | $105 | 2021-12-16 | Buy |
| Matrix Scientific | 080313 | Ethyl 3-amino-1-benzothiophene-2-carboxylate | 34761-09-6 | 5g | $399 | 2021-12-16 | Buy |
| Matrix Scientific | 080313 | Ethyl 3-amino-1-benzothiophene-2-carboxylate | 34761-09-6 | 1g | $126 | 2021-12-16 | Buy |
3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Uses,Production
Synthesis
394-47-8
623-51-8
![3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/34761-09-6.gif)
34761-09-6
The general procedure for the synthesis of ethyl 3-aminobenzo[B]thiophene-2-acetate from 2-fluorobenzonitrile and ethyl mercaptoacetate is as follows: Method 1: Synthesis of 4-aminobenzothiophene from 3,4-dipyrimidine 1A. Ethyl 3-amino-carboxylate 2-fluorobenzonitrile (8.25 mmol), diisopropylethylamine (8.25 mmol), and ethyl 2-mercaptoacetate (8.25 mmol) were dissolved in anhydrous N,N-dimethylformamide (5 mL) and stirred for 30 min at room temperature. Potassium carbonate (8.25 mmol) was then added and the reaction mixture was heated to 80 °C and maintained for 20 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice water, the precipitate was collected by filtration and washed with water to afford the target product carboxylate as a white solid in 92% yield. LCMS retention time 7.43 min, [M + H]+ 222; 1H-NMR (CDCl3) δ 7.43 (1H, d, J = 8.1 Hz), 7.65 (1H, d, J = 8.1 Hz), 7.49-7.44 (1H, m), 7.39-7.34 (1H, m), 4.36 (2H, q, J = 7.1 Hz), 1.40 (3H, t, J = 7.1 Hz).
References
[1] Patent: WO2012/131297, 2012, A1. Location in patent: Page/Page column 85
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3291 - 3297
[3] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 4, p. 1163 - 1172
3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3944 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shandong Liteng Biotechnology Co. , Ltd. | +86-18663721413 +86-15552573001 | rosy@litengpharm.com | China | 3285 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shandong Liteng Biotechnology Co., Ltd | 18663721413 | rosy@litengpharm.com | China | 934 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30123 | 84 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 | sales@shydchem.com.cn | China | 998 | 56 |
View Lastest Price from 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers
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2024-07-29 | 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
34761-09-6
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
34761-09-6
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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