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1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine

1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine Structure
1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine structure
CAS No.
23000-46-6
Chemical Name:
1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine
Synonyms
BUR1;BMP upregulator-1;BMP upregulator 1;BUR1, 10 mM in DMSO;1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine;1-{1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine;1H-Pyrazolo[3,4-d]pyrimidine, 1-phenyl-4-(1-piperidinyl)-
CBNumber:
CB64553023
Molecular Formula:
C16H17N5
Molecular Weight:
279.34
MDL Number:
MFCD00420078
MOL File:
23000-46-6.mol
Last updated:2025-09-20 20:09:13
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1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine Properties

Boiling point 416.3±38.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
pka 4.80±0.30(Predicted)
form Solid
color Light yellow to yellow

1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine Chemical Properties,Uses,Production

Description

BUR1 is a selective BMP upregulator. It acts by increasing expression of Inhibitor of DNA binding 1 (Id1) and inducing BMP2 and PTGS2 expression.

Uses

BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats[1].

in vivo

BUR1 (4.5 mg/day, i.g., 3 weeks) reverses MCT-induced pulmonary arterial pressure and right ventricular systolic pressure in rats[1].

References

[1] Xing Y, et al. A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels. Eur Respir J. 2018 Apr 4;51(4):1702229. DOI:10.1183/13993003.02229-2017

1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

4-HYDROXY-1-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE

Preparation Products

1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29545 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58
Shenzhen Zuoke Biotechnology Co., Ltd. 13532174601 CHINA 109 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12000 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 65
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Shenzhen Zuoke Biotechnology Co., Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

View Lastest Price from 1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BUR1 pictures 2025-09-19 BUR1
23000-46-6
 US $148.00-497.00 / mg 90.00% 10g TargetMol Chemicals Inc.
  • BUR1 pictures
  • BUR1
    23000-46-6
  • US $148.00-497.00 / mg
  • 90.00%
  • TargetMol Chemicals Inc.
1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine 1-{1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine BUR1 BMP upregulator 1 BMP upregulator-1 1H-Pyrazolo[3,4-d]pyrimidine, 1-phenyl-4-(1-piperidinyl)- BUR1, 10 mM in DMSO 23000-46-6