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4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one structure

CAS No.: 28664-35-9

Chemical Name:: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one

Synonyms: SOTOLON;3-hydroxy-4,5-dimethylfuran-2(5H)-one;SOTOLONE;3-HYDROXY-4,5-DIMETHYL-2(5H)-FURANONE;CARAMEL FURANONE;SUGAR LACTONE;FENUGREEK LACTONE;FEMA 3634;3-hydroxy-4,5-dimethyl-2(5H)-furanone (sotolon);4-hydroxy-2,3-dimethyl-2H-furan-5-one

CBNumber:: CB6466523

Molecular Formula:: C6H8O3

Molecular Weight:: 128.13

MDL Number:: MFCD00059957

MOL File:: 28664-35-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:02:50

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4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Properties

Melting point	26-29 °C(lit.)
Boiling point	184 °C(lit.)
Density	1.049 g/mL at 25 °C
FEMA	3634 \| 4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE
refractive index	n20/D 1.491(lit.)
FLAVIS Number	10.030 \| 3-Hydroxy-4,5-dimethylfuran-2(5H)-one
Flash point	>230 °F
storage temp.	Sealed in dry,2-8°C
pka	9.28±0.40(Predicted)
Odor	at 0.01 % in propylene glycol. extremely sweet strong caramel maple burnt sugar coffee
Appearance	White to off-white Solid
Odor Type	caramellic
biological source	synthetic
JECFA Number	243
Major Application	flavors and fragrances
InChI	1S/C6H8O3/c1-3-4(2)9-6(8)5(3)7/h4,7H,1-2H3
InChIKey	UNYNVICDCJHOPO-UHFFFAOYSA-N
SMILES	CC1OC(=O)C(O)=C1C
LogP	-0.44
CAS DataBase Reference	28664-35-9(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE
EWG's Food Scores	1
FDA UNII	T62RL2NEGW
NIST Chemistry Reference	2(5H)-furanone, 3-hydroxy-4,5-dimethyl-(28664-35-9)
EPA Substance Registry System	2(5H)-Furanone, 3-hydroxy-4,5-dimethyl- (28664-35-9)
UNSPSC Code	85151701
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

20/22

Safety Statements

WGK Germany

TSCA

TSCA listed

HS Code

29329990

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	1
0		0

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W363499	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one natural, ≥97%, FG	28664-35-9	1 each	$232	2026-04-30	Buy
Sigma-Aldrich	W363499	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one natural, ≥97%, FG	28664-35-9	25G	$299	2026-04-30	Buy
Sigma-Aldrich	W363499	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one natural, ≥97%, FG	28664-35-9	100G	$870	2026-04-30	Buy
Sigma-Aldrich	W363413	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution 10 wt. % in propylene glycol	28664-35-9	1 each	$55.9	2026-04-30	Buy
Sigma-Aldrich	W363405	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one ≥97%, FG	28664-35-9	1 each	$79.7	2026-04-30	Buy

Product number	Packaging	Price	Buy
W363499	1 each	$232	Buy
W363499	25G	$299	Buy
W363499	100G	$870	Buy
W363413	1 each	$55.9	Buy
W363405	1 each	$79.7	Buy

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Chemical Properties,Uses,Production

Chemical Properties

clear yellow liquid

Chemical Properties

3-Hydroxy-4,5-dimethyl-2(5H)-furanone was found in, for example, fenugreek, coffee, sake, and florsherry. Its aroma characteristic changes from caramel-like at low concentrations to curry-like at high concentrations. A method described for its preparation comprises condensation of ethyl propionate with diethyl oxalate and reaction of the intermediately formed diethyl oxalylpropionate with acetaldehyde. Acidic decarboxylation of the ethyl 4,5-dimethyl-2,3-dioxodihydrofuran-4-carboxylate gives the title compound.

Occurrence

Reported found in roasted Virginia tobacco, beef broth, beer, sherry, botryized wine, coffee, tea, fenugreek, sake and rice wine.

Uses

4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C3 is a labelled analogue of 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (D473600). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is a fragrant compound that is a key indicator of maple syrup urine disease, a disorder affecting newborn children that is the result of its inability to properly metabolize Valine (V094205), Leucine (L330110) and Isoleucine (I820175). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is naturally found in fenugreek seeds, and is an odourant present in sherry wines.

Definition

ChEBI: Sotolone is a butenolide. It has a role as a metabolite.

Aroma threshold values

Aroma characteristics at 1.0%; sweet, strong brown, cyclotene and maple like, caramel, toffee, maltol-like and burnt, brown sugar fenugreek-like, cooked and syrupy.

Taste threshold values

Taste characteristics at 5–25 ppm; sweet, caramel, maple, walnut, brown sugar, nutty, cotton candy, fenugreek and celery-like, rum, roasted meaty with a honey nuance

Biological Activity

Odor at 1.0%', 'Taste at 5-25 ppm

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Suppliers

Global( 281)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Haishan Technology Co. Ltd.	027-86637880 17720597715	3271849079@QQ.COM	China	466	58
Anhui Jinbo Flavors Co., Ltd	15102127101 15556562013	jinbo_bei@qq.com	China	1117	58
Hubei Soren Technology Co., Ltd	13419562052 13419562052	wwmlyb@163.com	China	4386	58
Wuhan Qingshan Heyuan Biotechnology Co., Ltd	027-18327024450 18327024450	2130026275@qq.com	China	4297	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
jiliang chemicals	21-62165282	bidingchem@163.com	China	1395	60
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
Beijing Isomersyn Technology CO;LTD	010-82954736 13391601435	sales@isomersyn.com	China	3294	57

Supplier	Advantage
Wuhan Haishan Technology Co. Ltd.	58
Anhui Jinbo Flavors Co., Ltd	58
Hubei Soren Technology Co., Ltd	58
Wuhan Qingshan Heyuan Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
jiliang chemicals	60
XiaoGan ShenYuan ChemPharm co,ltd	52
Beijing Isomersyn Technology CO;LTD	57

View Lastest Price from 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9	$30.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2026-05-15	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9	$1.50	1g	99.0% Min	100 Tons	Shaanxi Didu New Materials Co. Ltd
2025-06-27	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
28664-35-9
$30.00
99%
Henan Fengda Chemical Co., Ltd

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
28664-35-9
$1.50
99.0% Min
Shaanxi Didu New Materials Co. Ltd

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
28664-35-9
99%
Hebei Chuanghai Biotechnology Co., Ltd

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Spectrum

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one(28664-35-9)¹HNMR 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one(28664-35-9)FT-IR

28664-35-9(4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one)Related Search:

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Ethane Dimethylglyoxime disodium salt D-Glucono-1,5-lactone

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4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one AKA sugar lactone CARAMEL FURANONE (3% IN TRIACETIN) 4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (ca. 14% in propylene glycol) SUGAR LACTONE PURE 4 5-DIMETHYL-3-HYDROXY-2 5-DIHYDROFURAN& 3-Hydroxy-4,5-Dimethyl-2(5H)-Furanone 28664-35-9 sotolon,3-hydroxy-4,5-dimethyl-2(5H)-furanone 4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution caramel furanone solution 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE (CA. 10% IN PROPYLENE GLYCOL) 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE, CA. 3% IN PROPYLENE GLYCOL 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE 97% 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (ca. 14% in Propylene Glycol, ca. 1.2mol/L) CARAMEL FURANONE 0.1% IN P.G., NATURAL CARAMEL FURANONE IN 3% P.G. CARAMEL FURANONE, PURE 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one, Caramel furanone, Sotolon, Sugar lactone Caramel furanone, Sotolon, Sugar lactone 2,4-Dihydroxy-3,4-dimethyl-2-butenoic acid 1,4-lactone 4,5-Dimethyl-3-hydroxyfuran-2(5H)-one RI-2177 4,5-Dimethyl-3-hydroxy-2(5H)-furanone,98% 5-dihydrofuran-2-one 5-Dimethyl-3-hydroxy-2 4,5-Dimethyl-3-hydroxy-2(5H)-furanone, 97.5% 3-Hydoxy-4,5-dimethyl-2(5H)-furanone ,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 2,3-DIMETHYL-4-HYDROXY-2,5-DIHYDROFURAN-5-ONE 4,5-dimethyl-3-hydroxy-2(5H)- furanone (sotolon) dimethylhydroxyfuranone Furan-2(5H)-one, 3-hydroxy-4,5-dimethyl- 3-hydroxy-4,5-dimethyl-2(5h)-furanon 3-hydroxy-4,5-dimethyl-2(5H)-furanone (sotolon) 3-hydroxy-4,5-dimethyl-5H-furan-2-one Fenugreeklactone 3% 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one/Sotolon 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one USP/EP/BP 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one（Sugar lactone） 3-Hydroxy-4,5-dimethylfuran-2(5H)-one, ≥97% Sotolone, ≥97% 2(5H)-Furanone, 3-hydroxy-4,5-dimethyl- 3-HYDROXY-4,5-DIMETHYL-2(5H)-FURANONE 3-hydroxy-4,5-dimethylfuran-2(5H)-one 4-hydroxy-2,3-dimethyl-2H-furan-5-one CARAMEL FURANONE FEMA 3634 Fenugreck Lactone FENUGREEK LACTONE SOTOLON SOTOLONE SUGAR LACTONE 28664-35-9 food additives food additive