Description
JWH 019 N-(5-hydroxyhexyl) metabolite-d5 (Item No. 14687) is intended for use as an internal standard for the quantification of JWH 019 N-(5-hydroxyhexyl) metabolite (Item No. 14814) by GC- or LC-MS. Cannabimimetic indoles, including certain JWH compounds, have been identified in herbal blends. JWH 018, a potent agonist of both the central cannabinoid (CB1) receptor and peripheral cannabinoid (CB2) receptor, has been found in many herbal blends and has been regulated in the United States and other countries. Studies indicate that JWH 018 is rapidly metabolized by the liver and that certain metabolites can be identified in the urine.1,2,3 JWH 019 is nearly identical to JWH 018 in structure and activity at both CB receptors.4 JWH 019 N-(5-hydroxyhexyl) metabolite is an expected metabolite of JWH 019, detectable both in serum and urine. Its biological activities have not been evaluated. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.
References
[1] JÖRG TESKE. Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometry.[J]. Journal of Chromatography B, 2010, 878 27: 2659-2663. DOI: 10.1016/j.jchromb.2010.03.016
[2] TIM SOBOLEVSKY Grigory R Ilya Prasolov. Detection of JWH-018 metabolites in smoking mixture post-administration urine[J]. Forensic science international, 2010, 200 1: Pages 141-147. DOI: 10.1016/j.forsciint.2010.04.003
[3] ANNETTE WINTERMEYER. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018[J]. Analytical and Bioanalytical Chemistry, 2010, 398 5: 2141-2153. DOI: 10.1007/s00216-010-4171-0
[4] MIE MIE AUNG . Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding[J]. Drug and alcohol dependence, 2000, 60 2: Pages 133-140. DOI: 10.1016/s0376-8716(99)00152-0
