Risdiplam
- CAS No.
- 1825352-65-5
- Chemical Name:
- Risdiplam
- Synonyms
- RG7916;2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;Lispran;RO7034067;Risdiplam;2H4]-Risdiplam;Risdiplam (RG7916);Risdiplam (RG7916) ，S6925;Risdiplam (RG-7916, RO-7034067);7-amino-2,3-dihydro-1H-inden-4-ol
- CBNumber:
- CB64674494
- Molecular Formula:
- C22H23N7O
- Molecular Weight:
- 401.46
- MDL Number:
- MFCD31657372
- MOL File:
- 1825352-65-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Risdiplam ≥98% | 29028 | 1mg | $41 |
| Risdiplam ≥98% | 29028 | 5mg | $128 |
| Risdiplam ≥98% | 29028 | 10mg | $235 |
| Risdiplam ≥98% | 29028 | 25mg | $389 |
| Risdiplam | 29028 | 5mg | $116 |
| Density | 1.50±0.1 g/cm3(Predicted) |
|---|---|
| solubility | Soluble in DMSO |
| pka | 9.41±0.20(Predicted) |
| form | solid |
| color | Light yellow to yellow |
| InChI | InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3 |
| InChIKey | ASKZRYGFUPSJPN-UHFFFAOYSA-N |
| SMILES | C12C=CC(N3CC4(CC4)NCC3)=CN1C(=O)C=C(C1=NN3C=C(C)N=C3C(C)=C1)N=2 |
| FDA UNII | 76RS4S2ET1 |
| ATC code | M09AX10 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Risdiplam price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29028 | Risdiplam ≥98% | 1825352-65-5 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 29028 | Risdiplam ≥98% | 1825352-65-5 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 29028 | Risdiplam ≥98% | 1825352-65-5 | 10mg | $235 | 2026-04-30 | Buy |
| Cayman Chemical | 29028 | Risdiplam ≥98% | 1825352-65-5 | 25mg | $389 | 2026-04-30 | Buy |
| Cayman Chemical | 29028 | Risdiplam | 1825352-65-5 | 5mg | $116 | 2024-03-01 | Buy |
Risdiplam Chemical Properties,Uses,Production
Description
Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier.
Chemical Properties
light yellow powder to yellow powder
Uses
Risdiplam is used in preparation of Imidazopyridazinyl Pyridopyrimidinones for treating spinal muscular atrophy. Gene splicing modulator.
Mechanism of action
Risdiplam works by modifying the splicing process of the SMN2 gene, increasing the production of full-length and functional SMN protein.
Side effects
Body aches or pain, chest pain or tightness, chills, cough, ear congestion, fever, headache, loss of voice, runny or stuffy nose, sneezing, sore throat, trouble breathing, unusual tiredness or weakness and so on.
Synthesis
SNAr reaction between amine 194 and bromopyridine 195 gave 196 in good yield. Reduction by hydrogenation in the presence of a platinum catalyst followed by treatment with di-tert-butyl malonate gave pyridopyrimidone 197 in benzoxazole at elevated temperature in good overall yield for both steps. Mesylation to form sulfonate 198 then participated in a Suzuki coupling with 200 (derived from aryl chloride 199 via Miyaura coupling) to establish the risdiplam core skeleton. N-Boc deprotection of 201 using hydrochloric acid in isopropanol gave risdiplam (XXVI) which was isolated after pH adjustment.
storage
0-4℃ for short term (days to weeks) or -20℃ for long term (months)
Risdiplam Preparation Products And Raw materials
Raw materials
Preparation Products
Risdiplam Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1249 | 58 |
| Biopole Pharmatech Co., Ltd. | +8615151475053 | biopole@163.com | China | 37 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 861 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
Related articles
- How is Risdiplam synthesised?
- Risdiplam was approved by the USFDA for the treatment of spinal muscular atrophy caused by a mutation leading to a deficiency ....
- Dec 28，2023
View Lastest Price from Risdiplam manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Risdiplam
1825352-65-5
|
$55.00-129.00 | 99.35% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-20 | Risdiplam
1825352-65-5
|
1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | ||
 |
2025-02-13 | Risdiplam
1825352-65-5
|
$1.00 | 1g | 99% | 10000 | Apeloa production Co.,Limited |
