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AC-DEVD-CHO

AC-DEVD-CHO structure

CAS No.: 169332-60-9

Chemical Name:: AC-DEVD-CHO

Synonyms: MF 191;AC-DEVD-CHO;AC-DEVD-ALDEHYDE;AC-DEVD-CHO?, >98%;CASPASE-3 INHIBITOR;Ac-DEVD-CHO acetate;ACETYL-DEVD-ALDEHYDE;Ac-Asp-Glu-Val-Asp-H;CASPASE-3 INHIBITOR I;AC-DEVD-CHO USP/EP/BP

CBNumber:: CB6488321

Molecular Formula:: C20H30N4O11

Molecular Weight:: 502.47

MDL Number:: MFCD00671412

MOL File:: 169332-60-9.mol

MSDS File:: SDS

Last updated:2025-09-18 19:10:02

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AC-DEVD-CHO Properties

Boiling point	1021.1±65.0 °C(Predicted)
Density	1.374±0.06 g/cm3(Predicted)
RTECS	EK7643000
storage temp.	-20°C
solubility	H₂O: 1 mg/mL
pka	4.19±0.10(Predicted)
form	powder
color	white
biological source	synthetic
Water Solubility	H2O: 1mg/mL
Sensitive	Moisture Sensitive
Sequence	N-Acetyl-Asp-Glu-Val-Asp-al
UNSPSC Code	12352209
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3

AC-DEVD-CHO price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	235420	Caspase-3 Inhibitor I	169332-60-9	1mg	$122	2025-07-31	Buy
Sigma-Aldrich	235420	Caspase-3 Inhibitor I	169332-60-9	5mg	$488	2025-07-31	Buy
Sigma-Aldrich	A0835	N-Acetyl-Asp-Glu-Val-Asp-al ≥95%, powder	169332-60-9	1mg	$166	2025-07-31	Buy
Sigma-Aldrich	A0835	N-Acetyl-Asp-Glu-Val-Asp-al ≥95%, powder	169332-60-9	5mg	$572	2025-07-31	Buy
American Custom Chemicals Corporation	PEP0000973	AC-DEVD-CHO 95.00%	169332-60-9	1MG	$603.95	2021-12-16	Buy

Product number	Packaging	Price	Buy
235420	1mg	$122	Buy
235420	5mg	$488	Buy
A0835	1mg	$166	Buy
A0835	5mg	$572	Buy
PEP0000973	1MG	$603.95	Buy

AC-DEVD-CHO Chemical Properties,Uses,Production

Uses

Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase

Uses

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Definition

ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.

General Description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

in vivo

Compare with model group, in CI group, the concentrations of serum BUN are decreased significantly at all time points after operation and those of Cr are decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 are decreased and those of IL-10 are elevated significantly at all time points. [TNF-α (μg/L) 6 hours: 436.2±64.2 vs. 653.6±8.9, 12 hours: 233.4±85.4 vs. 579.7±137.1, 24 hours: 151.0±90.3 vs. 551.0±119.8, IL-6 (μg/L) 6 hours: 1033.2±345.8 vs. 1 595.3±159.4, 12 hours: 366.3±68.3 vs. 1 330.7±249.8, 24 hours: 241.2±208.4 vs. 815.3±572.7, IL-10 (μg/L) 6 hours: 33.6±10.4 vs. 26.6±4.5, 12 hours: 37.2±5.0 vs. 24.5±4.3, 24 hours: 38.3±5.5 vs. 18.2±1.6, all P<0.05]; the renal cell apoptosis rates are decreased significantly at all time points: apoptosis rates 6 hours: (13.9±3.2)% vs. (18.3±1.4)%, 12 hours: (10.5±3.6)% vs. (15.9±3.5)%, 24 hours: (8.4±1.8)% vs.(12.5±2.1)%^[5].

IC 50

Caspase 3: 0.23 nM (Ki); Caspase-8: 0.92 nM (Ki); Caspase-7: 1.6 nM (Ki); Caspase-10: 12 nM (Ki); Caspase-1: 18 nM (Ki); Caspase-6: 31 nM (Ki); Caspase-9: 60 nM (Ki); Caspase-4: 132 nM (Ki); Caspase-5: 205 nM (Ki); Caspase-2: 1710 nM (Ki)

AC-DEVD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

AC-DEVD-CHO Suppliers

Global( 116)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20603	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39030	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5218	58
DONBOO AMINO ACID COMPANY	+8618051385538	donboo@donboo.com	China	9363	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Dideu Industries Group Limited	58
Nextpeptide Inc	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
DONBOO AMINO ACID COMPANY	58

View Lastest Price from AC-DEVD-CHO manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-18	Ac-DEVD-CHO acetate	US $70.00-336.00 / mg		98.54%	10g	TargetMol Chemicals Inc.

Ac-DEVD-CHO acetate
US $70.00-336.00 / mg
98.54%
TargetMol Chemicals Inc.

169332-60-9(AC-DEVD-CHO)Related Search:

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Ac-DEVD-CHO,N-Acetyl-Asp-Glu-Val-Asp-al, >98% AC-DEVD-CHO?, >98% Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE N-AC-ASP-GLU-VAL-ASP-CHO N-ACETYL-ASP-GLU-VAL-ASP-AL N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE) CPP32/APOPAIN INHIBITOR CASPASE-3 INHIBITOR I CASPASE-3 INHIBITOR (ALDEHYDE) ACETYL-DEVD-ALDEHYDE ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPART-1-AL ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE AC-DEVD-CHO AC-DEVD-ALDEHYDE AC-ASP-GLU-VAL-ASP-ALDEHYDE AC-ASP-GLU-VAL-ASP-ALDEHYDE (PSEUDO ACID) AC-ASP-GLU-VAL-ASP-H (ALDEHYDE) AC-ASP-GLU-VAL-ASP-CHO Acetyl-aspartyl-glutamyl-valyl-aspartal CASPASE-3 INHIBITOR CASPASE 3 (APOPAIN) INHIBITOR 1 MF 191 N-acetyl-Asp-Glu-Val-Asp-Ala (4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxyMethyl)-13-forMyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid Ac-Asp-Glu-Val-Asp-H CASPASE-3 INHIBITOR I;N-AC-ASP-GLU-VAL-ASP-CHO;ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]- N-Acetyl-Asp-Glu-Val-Asp-al >=95%, powder AC-DEVD-CHO USP/EP/BP Ac-DEVD-CHO，N-Acetyl-Asp-Glu-Val-Asp-al Caspase 3 Inhibitor I,Caspase3 Inhibitor I AcDEVDCHO,Ac DEVD CHO Ac-DEVD-CHO acetate 169332-60-9 Caspase 10 Caspases Cell Biology Cell Signaling and Neuroscience Apoptosis and Cell Cycle BioChemical Inhibitors peptides Caspase 10 Caspase 3 Caspase 7 Caspase 8 Caspase Inhibitors Caspase Inhibitors and Substrates Peptides and Proteins Peptides for Cell Biology Protease Inhibitor Specificity Index Protease Inhibitors A to C A-AM Aldehydes and Substrates Apoptosis and Cell Cycle