2 4-DIHYDROXY-6-METHYLBENZALDEHYDE
- CAS No.
- 487-69-4
- Chemical Name:
- 2 4-DIHYDROXY-6-METHYLBENZALDEHYDE
- Synonyms
- 133345;Orcylaldehyde;Orcylic aldehyde;2,4-Dihydroxy-6-Methylbenz;6-Methyl-β-resorcyladehyde;2,4-Dihydroxy-6-methylbenzaldehyde;Benzaldehyde, 2,4-dihydroxy-6-methyl-;2,4-Dihydroxy-6-methylbenzaldehyde - [D71751]
- CBNumber:
- CB6500173
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00033852
- MOL File:
- 487-69-4.mol
- MSDS File:
- SDS
| Melting point | 180-184 °C |
|---|---|
| Boiling point | 321.9±22.0 °C(Predicted) |
| Density | 1.331±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| pka | 7.69±0.23(Predicted) |
| form | crystalline needles |
| color | Burnt orange |
| FDA UNII | 15U7JE2JVK |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H317-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-43 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| HS Code | 2912490090 |
2 4-DIHYDROXY-6-METHYLBENZALDEHYDE price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 657603 | 2,4-Dihydroxy-6-methylbenzaldehyde 97% | 487-69-4 | 1g | $237 | 2023-06-20 | Buy |
| Sigma-Aldrich | 657603 | 2,4-Dihydroxy-6-methylbenzaldehyde 97% | 487-69-4 | 5g | $752 | 2023-06-20 | Buy |
| TRC | D480863 | 2,4-Dihydroxy-6-methylbenzaldehyde | 487-69-4 | 100mg | $60 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2715-1-48 | 2,4-Dihydroxy-6-methylbenzaldehyde | 487-69-4 | 1g | $72 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD147432 | 2,4-Dihydroxy-6-methylbenzaldehyde | 487-69-4 | 250mg | $100 | 2021-12-16 | Buy |
2 4-DIHYDROXY-6-METHYLBENZALDEHYDE Chemical Properties,Uses,Production
Definition
ChEBI: 2,4-dihydroxy-6-methylbenzaldehyde is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde in which the hydrogen at position 6 has been replaced by a methyl group. It is a fungal metabolite isolated from Grifola frondosa and Phlebiopsis gigantea. It has a role as an apoptosis inducer, an anti-inflammatory agent and a fungal metabolite.
Synthesis
504-15-4
68-12-2
487-69-4
5-Methylbenzene-1,3-diol (25.0 g, 0.2 mol) was dissolved in N,N-dimethylformamide (100 mL) at 0 °C and slowly added dropwise to a pre-cooled mixture of POCl3 (44.0 g, 0.3 mol) and N,N-dimethylformamide (200 mL). After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly poured into ice water and the solid product was precipitated. The solid was collected by filtration and washed three times with distilled water to remove residual acid and solvent. Finally, the product was dried to afford 2,4-dihydroxy-6-methylbenzaldehyde (21.0 g, 82.0% yield), which could be used in subsequent reactions without further purification.
References
[1] Organic Letters, 2003, vol. 5, # 23, p. 4481 - 4484
[2] Patent: WO2004/58738, 2004, A1. Location in patent: Page 2/2; 10
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 5, p. 664 - 671
[4] Patent: WO2017/151489, 2017, A1. Location in patent: Paragraph 0284
[5] Molecules, 2018, vol. 23, # 10,
2 4-DIHYDROXY-6-METHYLBENZALDEHYDE Preparation Products And Raw materials
2 4-DIHYDROXY-6-METHYLBENZALDEHYDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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