Hexokinase I (C35C4) Rabbit mAb

Source

Rabbit

Reactivity

Human;Mouse

Background

Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III, and IV, have been identified. Hexokinases I, II, and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells in order to compensate for the increased energy demands associated with rapid cell growth and proliferation.

References

[1] WARBURG, O. (1956) Science 123, 309-14.
[2] Semenza, G.L. (2000) Crit Rev Biochem Mol Biol 35, 71-103.
[3] Smith, T.A. (2000) Br J Biomed Sci 57, 170-8.

Raw materials

Preparation Products