MSH2 (3A2) Mouse mAb

Source

Mouse

Reactivity

Human

Background

The DNA mismatch repair system repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex, a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex.Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer, the most common form of inherited colorectal cancer in the Western world. Mutations have also been associated with other sporadic tumors.

References

[1] O'Brien, V. and Brown, R. (2006) Carcinogenesis 27, 682-92.
[2] Wang, Y. et al. (2000) Genes Dev 14, 927-939.
[3] Plotz, G. et al. (2006) J Mol Histol 37, 271-83.

Raw materials

Preparation Products