PARN (P620) Antibody

Source

Rabbit

Reactivity

Human

Background

Cellular levels of mRNAs are controlled by mRNA stability, the rate of synthesis and the rate of degradation. The presence and length of the poly(A) tail has been associated with mRNA stability. Exonucleolytic shortening of the poly(A) tail is the process that initiates the decay of many eukaryotic mRNAs. Poly(A)-specific ribonuclease is the enzyme responsible for initiation of deadenylation and exonucleolytic shortening of mRNA transcripts. Through an evolutionarily conserved mechanism, PARN also translationally silences selective mRNAs during early embryonic development. PARN is constitutively expressed in most mammalian tissues and plays a critical role in the post-transcriptional control of gene expression.

References

[1] Morales, J. et al. (1997) J Biol Chem 272, 6607-13.
[2] Wilson, T. and Treisman, R. (1988) Nature 336, 396-9.
[3] Sachs, A.B. et al. (1997) Cell 89, 831-8.
[4] Fritz, D.T. et al. (2004) Cell Biochem Biophys 41, 265-78.

Raw materials

Preparation Products