Homocarbonyltopsentin
- CAS No.
- 172286-77-0
- Chemical Name:
- Homocarbonyltopsentin
- Synonyms
- PK4C9;Homocarbonyltopsentin;Methanone, [2-[(6-hydroxy-1H-indol-3-yl)carbonyl]-1H-imidazol-4-yl]-1H-indol-3-yl- (9CI)
- CBNumber:
- CB65848744
- Molecular Formula:
- C21H14N4O3
- Molecular Weight:
- 370.36
- MDL Number:
- MFCD32197189
- MOL File:
- 172286-77-0.mol
- MSDS File:
- SDS
| Melting point | >210 °C |
|---|---|
| Boiling point | 801.2±75.0 °C(Predicted) |
| Density | 1.539±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 125 mg/mL (337.51 mM) |
| pka | 7.50±0.10(Predicted) |
| form | Solid |
| color | White to yellow |
| InChI | 1S/C21H14N4O3/c26-11-5-6-13-15(9-23-17(13)7-11)20(28)21-24-10-18(25-21)19(27)14-8-22-16-4-2-1-3-12(14)16/h1-10,22-23,26H,(H,24,25) |
| InChIKey | DRCVQVIMGSWRLN-UHFFFAOYSA-N |
| SMILES | [nH]1c(nc(c1)C(=O)c4c5c([nH]c4)cccc5)C(=O)c2c3c([nH]c2)cc(cc3)O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Homocarbonyltopsentin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2448 | PK4C9 ≥98% (HPLC) | 172286-77-0 | 5MG | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2448 | PK4C9 ≥98% (HPLC) | 172286-77-0 | 25MG | $599 | 2026-04-30 | Buy |
| Biosynth | XGA28677 | Homocarbonyltopsentin | 172286-77-0 | 50mg | $2263 | 2026-06-05 | Buy |
| ChemScene | CS-0065845 | Homocarbonyltopsentin 99.82% | 172286-77-0 | 5mg | $238 | 2026-06-04 | Buy |
| ChemScene | CS-0065845 | Homocarbonyltopsentin 99.82% | 172286-77-0 | 10mg | $379 | 2026-06-04 | Buy |
Homocarbonyltopsentin Chemical Properties, Uses, Production
Uses
Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM[1].
Biological Activity
PK4C9 is a splice modulator of survival of motor neuron gene SMN2 th at increases production of full-length SMN protein. Spinal muscular atrophy (SMA) is a motor neuron disease caused by deficiency in SMN protein resulting from loss of expression of the SMN1 gene. The related SMN2 gene can compensate, but polymorphism in SMN2 often results in altered splicing and exclusion of exon 7, which is required for a full-length SMN transcript. PK4C9 binds to pentaloop conformations of the stem-loop RNA structure TSL2, a cis-regulatory element for E7 inclusion, and promotes a shift to triloop conformations th at display enhanced E7 splicing. In SMA cells, PK4C9 increased E7 inclusion by 40% accompanied by a 1.5-fold increase in SMN protein, a level shown to reverse SMA phenotypes in mice models.
References
[1] Garcia-Lopez A, et al. Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nat Commun. 2018 May 23;9(1):2032. DOI:10.1038/s41467-018-04110-1
Homocarbonyltopsentin Preparation Products And Raw materials
Raw materials
Preparation Products
Homocarbonyltopsentin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 959 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
View Latest Price from Homocarbonyltopsentin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-11 | Homocarbonyltopsentin
172286-77-0
|
10g | TargetMol Chemicals Inc. | ||||
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2025-07-18 | Homocarbonyltopsentin
172286-77-0
|
10g | TargetMol Chemicals Inc. |
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- Homocarbonyltopsentin
172286-77-0
- TargetMol Chemicals Inc.
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- Homocarbonyltopsentin
172286-77-0
- TargetMol Chemicals Inc.
