SERCA2a activator A
- CAS No.
- 2139330-34-8
- Chemical Name:
- SERCA2a activator A
- Synonyms
- SERCA2a activator A;SERCA2a activator 1;SERCA2a activator 1, 10 mM in DMSO;5'-Benzyl-1'-butyl-N-(naphthalen-2-ylsulfonyl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-4-carboxamide;[2,3'-Bipyridine]-4-carboxamide, 1'-butyl-1',6'-dihydro-N-(2-naphthalenylsulfonyl)-6'-oxo-5'-(phenylmethyl)-;Ca channels,phospholamban,Inhibitor,Ca2+ channels,SERCA2a activator 1,SERCA2a,SERCA-2a activator 1,failure,reticulum,Calcium Channel,Ca2+,sarcoplasmic,diastolic,heart,systolic,inhibit
- CBNumber:
- CB65867480
- Molecular Formula:
- C32H29N3O4S
- Molecular Weight:
- 551.66
- MDL Number:
- MFCD34469372
- MOL File:
- 2139330-34-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
SERCA2a activator A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0088739 | SERCA2a activator 1 99.71% | 2139330-34-8 | 1mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-0088739 | SERCA2a activator 1 99.71% | 2139330-34-8 | 5mg | $650 | 2026-06-04 | Buy |
| ChemScene | CS-0088739 | SERCA2a activator 1 99.71% | 2139330-34-8 | 10mg | $910 | 2026-06-04 | Buy |
| ChemScene | CS-0088739 | SERCA2a activator 1 99.71% | 2139330-34-8 | 25mg | $1456 | 2026-06-04 | Buy |
| ChemScene | CS-0088739 | SERCA2a activator 1 99.71% | 2139330-34-8 | 50mg | $2039 | 2026-06-04 | Buy |
SERCA2a activator A Chemical Properties, Uses, Production
Uses
SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure[1].
Biological Activity
SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure[1]. SERCA2a activator 1 (Compound A) activates the Ca2+-dependent ATPase activity of cardiac sarcoplasmic reticulum (SR) vesicles but not that of skeletal muscle SR vesicles that lack phospholamban (PLN). The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation[1]. SERCA2a activator 1 also increases the Ca2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. In isolated perfused rat hearts, the SERCA2a activator 1 enhances systolic and diastolic functions[1]. SERCA2a activator 1 (Compound A; 30mg/kg; intravenous injection; male Wistar rats) treatment significantly enhances the diastolic function in anesthetized normal rats[1].
in vivo
SERCA2a activator 1 (Compound A; 30mg/kg; intravenous injection; male Wistar rats) treatment significantly enhances the diastolic function in anesthetized normal rats[1].
| Animal Model: | Male Wistar rats (7-8 weeks old)[1] |
| Dosage: | 30mg/kg |
| Administration: | Intravenous injection |
| Result: | Significantly enhanced the diastolic function in anesthetized normal rats. |
References
[1]. Kaneko M, et al. A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban. Eur J Pharmacol. 2017 Nov 5;814:1-8.
SERCA2a activator A Preparation Products And Raw materials
Raw materials
Preparation Products
SERCA2a activator A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 960 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 890 | 58 |
View Latest Price from SERCA2a activator A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | SERCA2a activator 1
2139330-34-8
|
$197.00-695.00 | 99.75% | 10g | TargetMol Chemicals Inc. |
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- SERCA2a activator 1
2139330-34-8
- $197.00-695.00
- 99.75%
- TargetMol Chemicals Inc.
