AAK1 inhibitor 1
- CAS No.
- 2247894-32-0
- Chemical Name:
- AAK1 inhibitor 1
- Synonyms
- S C-AAK1-1;SGC AAK1 1;AAK1 inhibitor 1;SGC-AAK1-1, 10 mM in DMSO;Cyclopropanecarboxamide, N-[6-[3-[[(diethylamino)sulfonyl]amino]phenyl]-1H-indazol-3-yl]-;AAK1,BMP2K,pathway,kinase,Inhibitor,inhibit,associated,SGCAAK11,Wnt,SGC-AAK-1-1,AP2,SGC AAK1 1
- CBNumber:
- CB65867501
- Molecular Formula:
- C21H25N5O3S
- Molecular Weight:
- 427.52
- MDL Number:
- MFCD31689256
- MOL File:
- 2247894-32-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SGC-AAK1-1 ≥98% | 41118 | 5mg | $86 |
| SGC-AAK1-1 ≥98% | 41118 | 10mg | $163 |
| SGC-AAK1-1 ≥98% | 41118 | 25mg | $323 |
| SGC-AAK1-1 ≥98% | 41118 | 50mg | $601 |
| SGCAAK11 ≥98%(HPLC) | 6528 | 25 | $371 |
| Density | 1.424±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 7.30±0.50(Predicted) |
| form | Solid |
| color | Light brown to khaki |
| InChI | 1S/C21H25N5O3S/c1-3-26(4-2)30(28,29)25-17-7-5-6-15(12-17)16-10-11-18-19(13-16)23-24-20(18)22-21(27)14-8-9-14/h5-7,10-14,25H,3-4,8-9H2,1-2H3,(H2,22,23,24,27) |
| InChIKey | UCBIQZUJJSVQHL-UHFFFAOYSA-N |
| SMILES | CCN(CC)S(NC1=CC=CC(C2=CC(NN=C3NC(C4CC4)=O)=C3C=C2)=C1)(=O)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
AAK1 inhibitor 1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41118 | SGC-AAK1-1 ≥98% | 2247894-32-0 | 5mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 41118 | SGC-AAK1-1 ≥98% | 2247894-32-0 | 10mg | $163 | 2026-04-30 | Buy |
| Cayman Chemical | 41118 | SGC-AAK1-1 ≥98% | 2247894-32-0 | 25mg | $323 | 2026-04-30 | Buy |
| Cayman Chemical | 41118 | SGC-AAK1-1 ≥98% | 2247894-32-0 | 50mg | $601 | 2026-04-30 | Buy |
| Tocris | 6528 | SGCAAK11 ≥98%(HPLC) | 2247894-32-0 | 25 | $371 | 2021-12-16 | Buy |
AAK1 inhibitor 1 Chemical Properties,Uses,Production
Uses
SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].
Biological Activity
SGC-AAK1-1 is an ATP-competitive kinase inhibitor against AP2-associated protein kinase 1/AAK1 and BMP-2-inducible protein kinase/BIKE/BMP2K (Ki = 9.1 & 17 nM, respectively, by ATP site fluorescent tracer displacement assay; AAK1 IC50 = 270 nM by coupled enzyme assay). SGC-AAK1-1 downregulates cellular AP2M1 Thr156 phosphorylation level in a dose-dependent manner (ECmax ∼12.5 μM) without detectable cytotoxicity. Selectivity profiling identifies only 5 additional kinases among a panel of ∼400 with >50% inhibition by 1 μM SGC-AAK1-1 (KD = 72 nM/RIOK1, 290 nM/RIOK3, 260 nM/PIP5K1C, 880 nM/CDKL1, 960 nM/MYLK2 by DiscoverX KINOMEscan). SGC-AAK1-1N is a structure analog and the recommended negative control (IC50 = 11 μM by AAK1 activity assay; KD = 8.8 μM/AAK1 & >10 μM/BIKE vs. KD = 26 nM/AAK1 & 930 nM/BIKE with SGC-AAK1-1 by DiscoverX). For characterization details of SGC-AAK1-1, please visit the SGC-AAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.
SGC-AAK1-1N is the negative control for the active probe, SGC-AAK1-1. SGC-AAK1-1N is available from Sigma. To learn more about and purchase SGC-AAK1-1N, click here.
To learn about other SGC chemical probes, visit sigma.com/sgc
storage
Store at -20°C
References
[1] Agajanian MJ, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019 Jan 2;26(1):79-93.e8. DOI:10.1016/j.celrep.2018.12.023
AAK1 inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
AAK1 inhibitor 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10000 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9697 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Hebei Weite Medical Technology Co., Ltd | 13180081292 13180081292 | contact@wetogethermed.com | China | 7814 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59936 | 58 |
View Lastest Price from AAK1 inhibitor 1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | SGC-AAK1-1
2247894-32-0
|
US $38.00-148.00 / mg | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-22 | SGC-AAK1-1
2247894-32-0
|
US $38.00-148.00 / mg | 99.68% | 10g | TargetMol Chemicals Inc. |
-
- SGC-AAK1-1
2247894-32-0
- US $38.00-148.00 / mg
- 99.68%
- TargetMol Chemicals Inc.
-
- SGC-AAK1-1
2247894-32-0
- US $38.00-148.00 / mg
- 99.68%
- TargetMol Chemicals Inc.
