5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE
- CAS No.
- 51516-70-2
- Chemical Name:
- 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE
- Synonyms
- AKOS B029474;BUTTPARK 51\09-64;TIMTEC-BB SBB000407;5-Amino-1-(4-fluorophenyl);5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole97%;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole 97%;5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE;1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-fluorophenyl)-
- CBNumber:
- CB6663838
- Molecular Formula:
- C10H7FN4
- Molecular Weight:
- 202.19
- MDL Number:
- MFCD00102729
- MOL File:
- 51516-70-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile Aldrich | JRD0041 | 1g | $114 |
| 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | PC1070M | 250mg | $21 |
| 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | PC1070M | 1g | $24 |
| 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | PC1070M | 5g | $39 |
| 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | PC1070M | 25g | $190 |
| More product size | |||
| Melting point | 164-165°C |
|---|---|
| Boiling point | 394.1±37.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | -0.92±0.10(Predicted) |
| Appearance | Yellow to brown Solid |
| InChI | 1S/C10H7FN4/c11-8-1-3-9(4-2-8)15-10(13)7(5-12)6-14-15/h1-4,6H,13H2 |
| InChIKey | SZEJYPAPBGNEMH-UHFFFAOYSA-N |
| SMILES | Nc1c(cnn1-c2ccc(F)cc2)C#N |
| CAS DataBase Reference | 51516-70-2(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05, GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 20/21/22-41 |
| Safety Statements | 22-36/37/39-39-26 |
| RIDADR | 3439 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 2933199090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | JRD0041 | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile Aldrich | 51516-70-2 | 1g | $114 | 2026-04-30 | Buy |
| Apolloscientific | PC1070M | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | 51516-70-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC1070M | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | 51516-70-2 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC1070M | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | 51516-70-2 | 5g | $39 | 2026-06-04 | Buy |
| Apolloscientific | PC1070M | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 99% | 51516-70-2 | 25g | $190 | 2026-06-04 | Buy |
5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Chemical Properties,Uses,Production
Uses
5-Amino-1-(4-fluorophenyl)pyrazole-4-carbonitrile was used in the preparation of compounds that were shown to have anti-viral activity against TMV.
Synthesis
371-14-2
123-06-8
51516-70-2
GENERAL METHOD: (4-Fluorophenyl)hydrazine (0.001 mol) was mixed with 10 mL of ethanol, stirred and heated to reflux. Subsequently, ethoxymethylene malononitrile (0.001 mol) dissolved in 10 mL of ethanol was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. After completion of the reaction, the mixture was poured into 50 mL of ice water. The precipitate was collected by filtration and washed with cold water to afford 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile (10a) in 61% yield. The product characterization data were as follows: melting point: 173-174 °C. IR (cm^-1): 3297-3183 (NH2); 2225 (CN); 1662; 1568. ^1H NMR (400 MHz, DMSO-d6, TMS, δ in ppm): 7.31-7.25 (m, 2H, H3', H5'); 7.54- 7.49 (m, 2H, H2', H6'); 7.67 (s, 1H, H3). ^13C NMR (100 MHz, DMSO-d6, TMS, δ in ppm): 73.2 (C4); 114.8 (CN); 116.3 (d, J = 22.8 Hz, C3', C5'); 126.9 (d, J = 8.9 Hz, C2', C6'); 133.7 (d, J = 2.8 Hz, C1'); 141.7 (C5); 151.4 (C3); 161.2 (d, J = 243.6 Hz, C4'). ^19F NMR (376 MHz, DMSO-d6, TMS, δ in ppm): -114.26. EI-MS [M + 1]^+: 203.07.
References
[1] European Journal of Organic Chemistry, 2018, vol. 2018, # 13, p. 1514 - 1524
[2] Tetrahedron Letters, 2008, vol. 49, # 2, p. 305 - 310
[3] Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1876 - 1884
[4] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2892 - 2898
[5] Organic and Biomolecular Chemistry, 2007, vol. 5, # 17, p. 2758 - 2761
5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40228 | 62 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18207 | 66 | |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
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