ChemicalBook >> CAS DataBase List >>1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID structure

CAS No.: 68077-26-9

Chemical Name:: 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Synonyms: NORF-007;AKOS 1303;Norfloxacin Q-Acid;TIMTEC-BB SBB003042;Norfloxacin EP Imp A;Norfloxacin ImpurityⅠ;Norfloxacin Impurity 11;Norfloxacin EP Impurity A;Norfloxacincarboxylicacid;Norfloxacin impurity A CRS

CBNumber:: CB6669991

Molecular Formula:: C12H9ClFNO3

Molecular Weight:: 269.66

MDL Number:: MFCD00792459

MOL File:: 68077-26-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:24:15

Product description	Number	Pack Size	Price
7-CHLORO-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID Aldrich^CPR	R462462	1 unit	$197
Norfloxacin Related Compound A PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial	PHR2233	100mg	$742
Norfloxacin impurity A European Pharmacopoeia (EP) Reference Standard	N1230010	20 mg	$257
Norfloxacin impurity A	1471517	15mg	$1390
7-CHLORO-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID AldrichCPR	R462462	250MG	$179
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1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Properties

Melting point	245°C
Boiling point	437.9±45.0 °C(Predicted)
Density	1.3905 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka	-0.21±0.20(Predicted)
form	powder
color	White to Pale Yellow
Major Application	pharmaceutical (small molecule)
InChI	1S/C12H9ClFNO3/c1-2-15-5-7(12(17)18)11(16)6-3-9(14)8(13)4-10(6)15/h3-5H,2H2,1H3,(H,17,18)/p-1
InChIKey	WNNSMMJBBOPPOT-UHFFFAOYSA-N
SMILES	Fc1cc2c(cc1Cl)N(C=C(C2=O)C(=O)[O-])CC
CAS DataBase Reference	68077-26-9(CAS DataBase Reference)
FDA UNII	831B5OC9PQ
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H412
Precautionary statements	P273-P501
Risk Statements	52/53
Safety Statements	61
HazardClass	IRRITANT
HS Code	2933599550

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R462462	7-CHLORO-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID Aldrich^CPR	68077-26-9	1 unit	$197	2026-03-19	Buy
Sigma-Aldrich	PHR2233	Norfloxacin Related Compound A PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial	68077-26-9	100mg	$742	2026-03-19	Buy
Sigma-Aldrich	N1230010	Norfloxacin impurity A European Pharmacopoeia (EP) Reference Standard	68077-26-9	20 mg	$257	2026-03-19	Buy
Sigma-Aldrich	1471517	Norfloxacin impurity A	68077-26-9	15mg	$1390	2026-03-19	Buy
Sigma-Aldrich	R462462	7-CHLORO-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID AldrichCPR	68077-26-9	250MG	$179	2024-03-01	Buy

Product number	Packaging	Price	Buy
R462462	1 unit	$197	Buy
PHR2233	100mg	$742	Buy
N1230010	20 mg	$257	Buy
1471517	15mg	$1390	Buy
R462462	250MG	$179	Buy

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid (Norfloxacin EP Impurity A) is a Norfloxacin intermediate. Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid).

Synthesis

ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE

70458-94-5

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

68077-26-9

Ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (2.75 g, 9.24 mmol) was used as a raw material and dissolved in 60 mL of methanol. Subsequently, a 1:1 solution of hydrochloric acid (31.5 mL, 189 mmol) was added. The reaction mixture was heated to reflux for 2 h. Upon completion of the reaction, a white solid precipitated. The solid product was collected by filtration and washed with plenty of water. Finally, the product was dried in a vacuum oven for 2 h to afford 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-carbonylquinoline-3-carboxylic acid (2.46 g, yield: 89.5%).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4257 - 4265
[2] Liebigs Annalen der Chemie, 1987, p. 29 - 37
[3] Chemical Communications, 2018, vol. 54, # 15, p. 1869 - 1872
[4] Journal of Medicinal Chemistry, 1980, vol. 23, # 12, p. 1358 - 1363
[5] Patent: CN107445892, 2017, A. Location in patent: Paragraph 0016

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE Methanol Water Hydrochloric acid

Preparation Products

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Suppliers

Global( 200)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Unipharm pharmaceutical industry Co., Ltd	536-8266195 +8613953676784	lee@unipharm-sd.com	China	1202	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15079	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Unipharm pharmaceutical industry Co., Ltd	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid 68077-26-9	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-01	1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID 68077-26-9	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2019-07-06	1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID 68077-26-9	US $1.00 / kg	1kg	98%	100KG	Career Henan Chemical Co

7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid
68077-26-9
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
68077-26-9
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
68077-26-9
US $1.00 / kg
98%
Career Henan Chemical Co

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Spectrum

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID(68077-26-9)¹HNMR

68077-26-9(1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID)Related Search:

Norfloxacin Norfloxacin Impurity 2 6-Chloro-1-Ethyl-4-Oxo-7-(Piperazin-1-yl)-1,4-Dihydroquinoline-3-Carboxylic acid Desethylene Norfloxacin Hydrochloride Norfloxacin EP Impurity E

Norfloxacin EP Impurity H 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid Norfloxacin EP Impurity D Norfloxacin EP Impurity G Norfloxacin EP Impurity C

4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 3-Quinolinecarboxylic acid 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

METHYL 7-CHLORO-6-FLUORO-1-CYCLOPROPYL-1,4-DIHYDROGEN-4-OXO-3-QUINOLINE CARBOXYLATE AKOS 92521 AKOS 1306

1of4

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolind-3-carboxylic acid Norfloxacin EP Impurity A 7-CHLORO-1,4-DIHYDRO-1-ETHYL-6-FLUORO-4-OXO-3-QUINOLINECARBOXYLIC ACID 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO QUINOLINE-3-CARBOXYLIC ACID 7-CHLORO-1-ETHYL-6-FLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLIC ACID AKOS 1303 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID 1-ETHYL-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID TIMTEC-BB SBB003042 7-Chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylicacid7-Chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylicacid 7-CHLORO-1,4-DIHYDRO-L-ETHYL-6-FLUORO-4-OXO-3-QUINOLINECARBOXYLIC ACID 7-CHLORO-1-ETHYL-6-FLUORO-4-OXOBYDROQUINOINE-3-CARBOXYLIC ACID 7-CHLORO-1-ETHYL-6-FLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLIC ACID 98% 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBO Norfloxacin ImpurityⅠ：Norfloxacin EP Impurity A 7-chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylate Norfloxacin EP Imp A 1-ETHYL-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDNORFLOXACIN A mixture of: 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 5-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 1-Ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloroquinoline-3-carboxylic acid 7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid A mixture of: 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and 5-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 7-Chloro-1-ethyl-6-fluoro-4-oxohydroquinoline-3-carboxylic acid,98% 1-Ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-3-quinolinecarboxylic Acid Norfloxacin Q-Acid 7-CHLORO-6-FLUORO-1-ETHYL-4-OXOQUINOLINE-3-CARBOXYLIC ACID NORF-007 Norfloxacin Impurity 1(Norfloxacin EP Impurity A) 3-Quinolinecarboxylicacid, 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo- Norfloxacin impurity A CRS 7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4 7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid > Norfloxacin Related Compound A (15 mg) Norfloxacin EP Impurity A/ Norfloxacin Related Compound A TIANFU-CHEM CAS:68077-26-9 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Norfloxacin Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic a (1471517) Pefloxacin Mesilate Dihydrate Impurity F Norfloxacin USP Related Compound A Pefloxacin Mesilate Dihydrate EP Impurity F 6-chloro-1-ethyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Norfloxacin Impurity 11 Norfloxacin ImpurityⅠ Norfloxacincarboxylicacid Norfloxacin ImpurityⅠ：Norfloxacin EP Impurity A Norfloxacin EP Impurity A (Norfloxacin USP Related Compound A, Pefloxacin EP Impurity F) 68077-26-9 8077-26-9 C12H9ClFNO3 Aromatics Intermediates & Fine Chemicals Pharmaceuticals