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5-Amino-2-methylpyridine

5-Amino-2-methylpyridine structure

CAS No.: 3430-14-6

Chemical Name:: 5-Amino-2-methylpyridine

Synonyms: 6-Methylpyridin-3-amine;5-AMINO-2-PICOLINE;6-METHYL-PYRIDIN-3-YLAMINE;AURORA KA-7923;5-Aminopicoline;3-AMINO-6-PICOLINE;5-Amino-2-methylpyri;6-Methyl-Pyridin-3-yl;5-Amino-2-methypyridine;2-Methyl-5-Aminoyridine

CBNumber:: CB6700252

Molecular Formula:: C6H8N2

Molecular Weight:: 108.14

MDL Number:: MFCD00833389

MOL File:: 3430-14-6.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
5-Amino-2-methylpyridine 97%	662704	1g	$34.19
5-Amino-2-methylpyridine 97%	662704	250mg	$33
5-Amino-2-methylpyridine >98.0%(GC)(T)	A2053	1g	$21
5-Amino-2-methylpyridine >98.0%(GC)(T)	A2053	5g	$62
6-Methylpyridine-3-amine	M327020	5g	$495
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5-Amino-2-methylpyridine Properties

Melting point	95-99°C
Boiling point	238.4±20.0 °C(Predicted)
Density	1.068±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	6.89±0.10(Predicted)
form	Powder
color	Off-white to orange to brown
InChI	InChI=1S/C6H8N2/c1-5-2-3-6(7)4-8-5/h2-4H,7H2,1H3
InChIKey	UENBBJXGCWILBM-UHFFFAOYSA-N
SMILES	C1=NC(C)=CC=C1N
LogP	0.704
CAS DataBase Reference	3430-14-6(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

Xn,Xi,C

Risk Statements

22-37/38-41-36/37/38-34-24/25

Safety Statements

26-36/39-45-36/37/39-36-27-36/37

RIDADR

UN2811

WGK Germany

Hazard Note

Harmful

HazardClass

6.1

PackingGroup

III

HS Code

29333999

NFPA 704

	1
2		0

5-Amino-2-methylpyridine price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	662704	5-Amino-2-methylpyridine 97%	3430-14-6	1g	$34.19	2025-07-31	Buy
Sigma-Aldrich	662704	5-Amino-2-methylpyridine 97%	3430-14-6	250mg	$33	2023-06-20	Buy
TCI Chemical	A2053	5-Amino-2-methylpyridine >98.0%(GC)(T)	3430-14-6	1g	$21	2025-07-31	Buy
TCI Chemical	A2053	5-Amino-2-methylpyridine >98.0%(GC)(T)	3430-14-6	5g	$62	2025-07-31	Buy
TRC	M327020	6-Methylpyridine-3-amine	3430-14-6	5g	$495	2021-12-16	Buy

Product number	Packaging	Price	Buy
662704	1g	$34.19	Buy
662704	250mg	$33	Buy
A2053	1g	$21	Buy
A2053	5g	$62	Buy
M327020	5g	$495	Buy

5-Amino-2-methylpyridine Chemical Properties,Uses,Production

Chemical Properties

White to orange to brown solid

Uses

6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.

General Description

5-Amino-2-methylpyridine is used as a pharmaceutical intermediate for Omecamtiv Mecarbil, a selective cardiac myosin activator used to improve cardiac function.

Synthesis

21203-68-9

80287-53-2

To a 250 mL autoclave was added 100 mL of methanol (MeOH), 2-methyl-5-nitropyridine (15 g, 0.19 mol, 1.0 eq.) and 10% palladium/carbon catalyst (0.5 g, 3.3 wt%). The reaction mixture was stirred at room temperature for 18 h under 4 atm hydrogen pressure. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 3:1) to confirm the completion of the reaction. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst. The filtrate was concentrated under reduced pressure to afford 3-amino-6-methylpyridine (11.5 g, HPLC purity: 97%) as a dark red solid in 98.3% yield.

References

[1] Patent: WO2018/208630, 2018, A1. Location in patent: Page/Page column 55
[2] Patent: US5580872, 1996, A
[3] Patent: US5733912, 1998, A
[4] Chemische Berichte, 1939, vol. 72, p. 577,579
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 22, p. 4676 - 4686

5-Amino-2-methylpyridine Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide Ethanol 2-Picoline Palladium 1,4-Dioxane

Tetrahydrofuran Trifluoroacetic anhydride Sulfuryl chloride Ethyl acetate Hydrochloric acid

Nitric acid Bromine Sodium hydroxide Diethyl malonate 2-Chloro-5-nitropyridine

Isopropyl alcohol Methyl 6-methylnicotinate Ammonia Sodium metabisulfite

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Preparation Products

5-METHOXYPYRIDINE-2-CARBOXYLIC ACID 6-IODO-5-METHOXY-2-PYRIDINECARBOXYLIC ACID diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate Nalidixic acid ethyl 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate

2-IODO-3-METHOXY-6-METHYLPYRIDINE 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid 2-Amino-5-hydroxypyridine 3-Hydroxy-2-iodo-6-methylpyridine 3-Hydroxy-6-methylpyridine

5-HYDROXYPYRIDINE-2-CARBOHYDRAZIDE 5-Chloropyridine-2-carboxylic acid 5-METHOXY-2-METHYLPYRIDINE 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID 5-Aminopyridine-2-carboxylic Acid

6-Bromo-5-methoxypicolinic acid 5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

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5-Amino-2-methylpyridine Suppliers

Global( 578)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Terma Medicare India Pvt.,Ltd	+86-53530655; +8613916485955	shivshanghai@yahoo.com	India	279	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12246	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
PNP Biotech Co. Ltd	+8618516098983	sales@pnpbiotech.com	China	1001	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
hebei hongtan Biotechnology Co., Ltd	+852-6619 3215 +86-17731935328	sales03@chemcn.cn	China	970	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60

Supplier	Advantage
Terma Medicare India Pvt.,Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
PNP Biotech Co. Ltd	58
Henan Fengda Chemical Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Fluoropharm Co., Ltd.	60

View Lastest Price from 5-Amino-2-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	5-Amino-2-methylpyridine 3430-14-6	US $5.00-0.10 / KG	1KG	98%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-08-08	5-Amino-2-methylpyridine 3430-14-6	US $0.00 / KG	1KG	99%	50000KG/month	Sichuan Zhuoyu Yantang Technology Co., Ltd.
2025-07-25	5-Amino-2-methylpyridine 3430-14-6	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

5-Amino-2-methylpyridine
3430-14-6
US $5.00-0.10 / KG
98%
Henan Fengda Chemical Co., Ltd

5-Amino-2-methylpyridine
3430-14-6
US $0.00 / KG
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

5-Amino-2-methylpyridine
3430-14-6
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

5-Amino-2-methylpyridine Spectrum

5-Amino-2-methylpyridine(3430-14-6)MS 5-Amino-2-methylpyridine(3430-14-6)¹HNMR 5-Amino-2-methylpyridine(3430-14-6)¹³CNMR 5-Amino-2-methylpyridine(3430-14-6)IR1 5-Amino-2-methylpyridine(3430-14-6)IR2

3430-14-6(5-Amino-2-methylpyridine)Related Search:

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2.4.6-TRIMETHYL-3-NITROPYRIDINE 2-Amino-3,5-dinitro-6-methylpyridine 5-Amino-2-methylpyridine Streptonigrin 3-AMINO-2,6-DIMETHYLPYRIDINE

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6-Methylpyridin-3-amine, 5-Amino-2-picoline 5-Amino-2-methylpyridine,97% 5-Amino-2-methypyridine 5-Amino-2-methylpyridine 97% 6-METHYL-PYRIDIN-3-YLAMINE 5-AMINO-2-METHYLPYRIDINE 5-AMINO-2-PICOLINE 3-AMINO-6-PICOLINE 3-AMINO-6-METHYLPYRIDINE 2-METHYL-5-AMINOPYRIDINE 2-Methyl-5-Aminoyridine 6-Methyl-Pyridin-3-yl 6-Methylpyridine-3-Amine 3-Pyridinamine,6-methyl-(9CI) AURORA KA-7923 6-Methyl-3-aminopyridine 2-METHYL-5-AMINOPYRIDINE / 3-AMINO-6-PICOLINE 5-AMINO-2-METHYLPYRIDINE (5-AMINO-2-PICOLINE) 3-Pyridinamine, 6-methyl- 5-amino-2-methylpyridine UNDER RD 6-Methylpyridin-3-amine 5-Amino-2-methylpyridine ,98% 3-amine-6-methylpyridine 5-Amino-2-methylpyri 5-Aminopicoline 5-Amino-2-methylpyridine > 5-Bromo-4-nitropicolinonitrile 5-Amino-2-methylpyridine ISO 9001：2015 REACH 5-Amino-2-methylpyridine/6-Methylpyridin-3-ylamine Ritlecitinib Impurity 1 3430-14-6 3430146 Pyridines Heterocyclic Building Blocks Building Blocks C6 Pyridine Pyridine Series Amines Pyridines derivates VARIOUSAMINE pyridines