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CYTOCHALASIN A

CAS No.
14110-64-6
Chemical Name:
CYTOCHALASIN A
Synonyms
Dehydrophomin;CYTOCHALASIN A;CYTOCHALASIN A(RG);5,5-Didehydrophomin;Cytochalasin dreschslera dematioidea;CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA;CytochalasinA from Drechslera dematioidea;cytochalasin a from helminthosporium dematioideum;Cytochalasin A from Drechslera dematioidea;Cytochalasin A 5-Dehydrophomin Dehydrophomin
CBNumber:
CB6735221
Molecular Formula:
C29H35NO5
Molecular Weight:
477.59
MDL Number:
MFCD00005935
MOL File:
14110-64-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:34:04
Product description Number Pack Size Price
Cytochalasin A from Drechslera dematioidea C6637 1mg $180
Cytochalasin A ≥98% 11327 1mg $55
Cytochalasin A ≥98% 11327 5mg $215
Cytochalasin A ≥98% 11327 10mg $401
Cytochalasin A ≥98% 11327 1mg $50
More product size

CYTOCHALASIN A Properties

Melting point 190-191 °C
Boiling point 725.1±60.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility ethanol: 20 mg/mL, clear, colorless
form Powder
pka 13.54±0.70(Predicted)
color White
Water Solubility Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.
Sensitive Light Sensitive
BRN 949521
InChIKey ZMAODHOXRBLOQO-TZVKRXPSSA-N
SMILES C[C@@H]1CCCC(=O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
LogP 1.849 (est)
FDA UNII BV8WQ9500E
EPA Substance Registry System Cytochalasin A (14110-64-6)
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H300+H310+H330-H361
Precautionary statements  P201-P202-P260-P280-P302+P352+P310-P304+P340+P310
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  T+,T
Risk Statements  26/27/28-63
Safety Statements  28-36/37-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
10
HazardClass  6.1(a)
PackingGroup  I
HS Code  29349990
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 1 Inhalation
Acute Tox. 2 Dermal
Acute Tox. 2 Oral
Repr. 2
NFPA 704
0
4 0

CYTOCHALASIN A price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C6637 Cytochalasin A from Drechslera dematioidea 14110-64-6 1mg $180 2026-04-30 Buy
Cayman Chemical 11327 Cytochalasin A ≥98% 14110-64-6 1mg $55 2026-04-30 Buy
Cayman Chemical 11327 Cytochalasin A ≥98% 14110-64-6 5mg $215 2026-04-30 Buy
Cayman Chemical 11327 Cytochalasin A ≥98% 14110-64-6 10mg $401 2026-04-30 Buy
Cayman Chemical 11327 Cytochalasin A ≥98% 14110-64-6 1mg $50 2024-03-01 Buy
Product number Packaging Price Buy
C6637 1mg $180 Buy
11327 1mg $55 Buy
11327 5mg $215 Buy
11327 10mg $401 Buy
11327 1mg $50 Buy

CYTOCHALASIN A Chemical Properties,Uses,Production

Description

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.

Chemical Properties

white powder

Uses

Cytochalasin A is one of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin A exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of the class display diverse selectivity. Specifically, cytochalasin A is one of the few cytochalasins exhibiting activity against HIV-1 protease.

Uses

Cytochalasin A binds to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Preventing growth and sugar uptake in a Saccharomyces strain.

Definition

ChEBI: Cytochalasin A is a cytochalasin.

Biochem/physiol Actions

Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces. Cytochalasin A is an oxidizing analog of cytochalsin B.

References

[1] R B LINGHAM. L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. III. Biological activity.[J]. Journal of Antibiotics, 1992, 45 5: 686-691. DOI: 10.7164/antibiotics.45.686
[2] TSUYOSHI ARAKI  Jeffrey G W. Perturbations of the actin cytoskeleton activate a Dictyostelium STAT signalling pathway[J]. European journal of cell biology, 2012, 91 5: Pages 420-425. DOI: 10.1016/j.ejcb.2012.01.002

14930-96-2
14110-64-6
Synthesis of CYTOCHALASIN A from CYTOCHALASIN B

CYTOCHALASIN A Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 116)Suppliers
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BOC Sciences
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TargetMol Chemicals Inc.
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DAYANG CHEM (HANGZHOU) CO.,LTD
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J & K SCIENTIFIC LTD. 18210857532; 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40228 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4794 58
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17770 75
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51395 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58

View Lastest Price from CYTOCHALASIN A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cytochalasin A pictures 2026-05-19 Cytochalasin A
14110-64-6
$165.00 10g TargetMol Chemicals Inc.
(7S,13E,16R,21E)-7-Hydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,20,23-trione 5,5-Didehydrophomin Dehydrophomin Cytochalasin dreschslera dematioidea Cytochalasin A 5-Dehydrophomin Dehydrophomin 7(S)-hydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,20,23-trione 2H-Oxacyclotetradecino2,3-disoindole-2,5,18-trione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,9R,11E,12aS,13S,15S,15aS,16S,18aS)- CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 99.0% (TLC) CYTOCHALASIN A cytochalasin a from helminthosporium dematioideum CYTOCHALASIN A(RG) CytochalasinA from Drechslera dematioidea Cytochalasin A from Drechslera dematioidea 14110-64-6 C29H35NO5 Other Cytoskeleton and Extracellular Matrix Enzymes, Inhibitors, and Substrates Enzyme Inhibitors Enzyme Inhibitors by Type Cell Biology Cell Signaling and Neuroscience Biochemicals and Reagents BioChemical Actin Inhibitors and Probes Actin Inhibitors and ProbesCell Signaling and Neuroscience Cell Signaling and Neuroscience antibiotic Cytoskeleton and Extracellular Matrix Mold Toxins and Venoms