3-Amino-5-(trifluoromethyl)benzoic acid
- CAS No.
- 328-68-7
- Chemical Name:
- 3-Amino-5-(trifluoromethyl)benzoic acid
- Synonyms
- BUTTPARK 25\01-23;3-AMINO-5-(TRIFLUOROMETHYL)BENZOIC ACID;3-AMINO-5-(TRIFLUOROEMTHYL)BENZOIC ACID;3-Amino-5-(trifluoromethyl)benzoicacid97%;Benzoic acid, 3-amino-5-(trifluoromethyl)-;3-Amino-5-(trifluoromethyl)benzoic acid 97%;3-Amino-5-(trifluoromethyl)benzoic Acid >3-Amino-5-(trifluoromethyl)benzoic acid USP/EP/BP;3-Amino-5-carboxybenzotrifluoride, 3-Carboxy-5-(trifluoromethyl)aniline
- CBNumber:
- CB6763695
- Molecular Formula:
- C8H6F3NO2
- Molecular Weight:
- 205.13
- MDL Number:
- MFCD00236641
- MOL File:
- 328-68-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Amino-5-(trifluoromethyl)benzoic acid 97% | 579513 | 1g | $71 |
| 3-Amino-5-(trifluoromethyl)benzoic Acid >97.0%(HPLC)(T) | A2481 | 1g | $226 |
| 3-Amino-5-(trifluoromethyl)benzoic acid 97% | PC1100CD | 5g | $43 |
| 3-Amino-5-(trifluoromethyl)benzoic acid 97% | PC1100CD | 25g | $147 |
| 3-Amino-5-(trifluoromethyl)benzoic acid 97% | PC1100CD | 100g | $471 |
| Melting point | 141-146 °C(lit.) |
|---|---|
| Boiling point | 331.9±42.0 °C(Predicted) |
| Density | 1.489±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.93±0.10(Predicted) |
| color | Light yellow to Yellow to Orange |
| Major Application | peptide synthesis |
| InChI | 1S/C8H6F3NO2/c9-8(10,11)5-1-4(7(13)14)2-6(12)3-5/h1-3H,12H2,(H,13,14) |
| InChIKey | WBTHOSZMTIPJLR-UHFFFAOYSA-N |
| SMILES | Nc1cc(cc(c1)C(F)(F)F)C(O)=O |
| CAS DataBase Reference | 328-68-7(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DD6205700 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Amino-5-(trifluoromethyl)benzoic acid price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 579513 | 3-Amino-5-(trifluoromethyl)benzoic acid 97% | 328-68-7 | 1g | $71 | 2026-04-30 | Buy |
| TCI Chemical | A2481 | 3-Amino-5-(trifluoromethyl)benzoic Acid >97.0%(HPLC)(T) | 328-68-7 | 1g | $226 | 2024-03-01 | Buy |
| Apolloscientific | PC1100CD | 3-Amino-5-(trifluoromethyl)benzoic acid 97% | 328-68-7 | 5g | $43 | 2026-06-04 | Buy |
| Apolloscientific | PC1100CD | 3-Amino-5-(trifluoromethyl)benzoic acid 97% | 328-68-7 | 25g | $147 | 2026-06-04 | Buy |
| Apolloscientific | PC1100CD | 3-Amino-5-(trifluoromethyl)benzoic acid 97% | 328-68-7 | 100g | $471 | 2026-06-04 | Buy |
3-Amino-5-(trifluoromethyl)benzoic acid Chemical Properties,Uses,Production
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
328-80-3
328-68-7
The suspension formed by 3-nitro-5-(trifluoromethyl)benzoic acid (103 g x 2 batches) obtained in step 1 and 10% palladium-carbon catalyst (5.15 g x 2 batches) in ethanol (1500 mL x 2 batches) was placed under the atmosphere of hydrogen at 1 atmospheric pressure, and the reaction was stirred for 7 hours at room temperature. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 3-amino-5-(trifluoromethyl)benzoic acid (180 g, 100% yield) as a light yellow powder. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.00-6.00 (2H, broad peak), 7.10 (1H, single peak), 7.53 (1H, single peak), 7.72 (1H, single peak).
References
[1] Patent: US2008/275085, 2008, A1. Location in patent: Page/Page column 45
[2] Chemistry - A European Journal, 2017, vol. 23, # 52, p. 12758 - 12762
[3] Patent: US2007/213371, 2007, A1. Location in patent: Page/Page column 70
[4] Journal of the American Chemical Society, 2017, vol. 139, # 43, p. 15308 - 15311
[5] Patent: WO2004/29038, 2004, A1. Location in patent: Page 44
3-Amino-5-(trifluoromethyl)benzoic acid Preparation Products And Raw materials
3-Amino-5-(trifluoromethyl)benzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9545 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28509 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
View Lastest Price from 3-Amino-5-(trifluoromethyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-12 | 3-Amino-5-(trifluoromethyl)benzoic acid
328-68-7
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 3-Amino-5-(trifluoromethyl)benzoic acid
328-68-7
- $1.00
- 99%
- Career Henan Chemical Co
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