5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol
- CAS No.
- 193001-14-8
- Chemical Name:
- 5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol
- Synonyms
- CS-744;ZM323881;KDR/FLK-1 INHIBITOR V;VEGF RECEPTOR 2 KINASE INHIBITOR V;5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol;4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol;Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-
- CBNumber:
- CB6811963
- Molecular Formula:
- C22H18FN3O2
- Molecular Weight:
- 375.4
- MDL Number:
- MFCD08703130
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A3954 | ZM323881 | 193001-14-8 | 10mg | $168 | 2026-05-06 | Buy |
| ApexBio Technology | A3954 | ZM323881 | 193001-14-8 | 50mg | $675 | 2026-05-06 | Buy |
| ACHEMBLOCK | X186133 | 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-Phenol 95% | 193001-14-8 | 100MG | $590 | 2026-05-27 | Buy |
| ACHEMBLOCK | X186133 | 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-Phenol 95% | 193001-14-8 | 250MG | $940 | 2026-05-27 | Buy |
| Crysdot | CD31002822 | ZM323881 98+% | 193001-14-8 | 10mg | $76 | 2026-05-27 | Buy |
5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol Chemical Properties, Uses, Production
Definition
ChEBI: ZM 323881 is a member of the class of quinazolines carrying 2-fluoro-4-methyl-5-hydroxyanilino and benzyloxy substituents at positions 4 and 7 respectively. It has a role as a vascular endothelial growth factor receptor antagonist. It is a benzyl ether, an aromatic ether, a member of quinazolines, a secondary amino compound, a substituted aniline, a halophenol, a member of monofluorobenzenes, an organic cation and a fluorophenol. It is a conjugate base of a ZM 323881(1+).
Biological Activity
zm323881 inhibits vegf-a-induced endothelial cell proliferation (ic50 = 8 nm) and vegf-r2 tyrosine phosphorylation (ic50 < 2 nm).vascular endothelial growth factor (vegf) increases vascular permeability and angiogenesis in many pathological conditions, such as cancer, arthritis, and diabetes. vegf activates vegf-receptor 1 (vegf-r1) and vegf-receptor 2 (vegf-r2) that autophosphorylate to initiate a signaling cascade resulting in angiogenesis and increased microvascular permeability. zm323881 is a potent and selective inhibitor of vegf-r2 tyrosine kinase.
in vitro
zm323881 was found to inhibit vegf-a-induced endothelial cell proliferation (ic50 = 8 nm) and vegf-r2 tyrosine phosphorylation in vitro (ic50 < 2 nm) [1].
in vivo
vegf-amediated increases in vascular permeability in perfused mesenteric microvessels in vivo were reversibly abolished by both zm323881 and the class iii receptor tyrosine kinase inhibitor ptk787/zk222584, suggesting that vegf-r2 phosphorylation is necessary for vegf-a-mediated increases in microvascular permeability in vivo [1].
target
VEGFR-2/KDR
References
[1] whittles ce, pocock tm, wedge sr, kendrew j, hennequin lf, harper sj, bates do. zm323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. microcirculation. 2002;9(6):513-22.
5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Rlavie Technology Co., Ltd. | 021-67759270 17717059219 | sales@rlavie.com | China | 1850 | 55 |
