ChemicalBook >> CAS DataBase List >>1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
![1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Structure](CAS/20210111/GIF/2222114-64-7.gif)
- CAS No.
- 2222114-64-7
- Chemical Name:
- 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- Synonyms
- Thalidomide-piperazine-Boc;Thalidomide-5-piperazine-Boc;tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- CBNumber:
- CB68192310
- Molecular Formula:
- C22H26N4O6
- Molecular Weight:
- 442.46
- MDL Number:
- MFCD32705088
- MOL File:
- 2222114-64-7.mol
Last updated:2025-07-04 15:26:58
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Properties
| Boiling point | 674.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.373±0.06 g/cm3(Predicted) |
| solubility | DMSO : 41.67 mg/mL (94.18 mM; Need ultrasonic) |
| pka | 10.83±0.40(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| InChI | InChI=1S/C22H26N4O6/c1-22(2,3)32-21(31)25-10-8-24(9-11-25)13-4-5-14-15(12-13)20(30)26(19(14)29)16-6-7-17(27)23-18(16)28/h4-5,12,16H,6-11H2,1-3H3,(H,23,27,28) |
| InChIKey | PMKVKOLFYHLKAP-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCN(C2C=CC3=C(C=2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1 |
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Chemical Properties,Uses,Production
Uses
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1].
Biological Activity
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1].
IC 50
Cereblon
References
[1]. Michael Berlin, et al. Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety. WO2021077010A1.
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Suppliers
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| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
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| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | Sales@changyanchem.cn | China | 5009 | 55 |
View Lastest Price from 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-05 | Thalidomide-piperazine-Boc
2222114-64-7
|
US $46.00-78.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Thalidomide-piperazine-Boc
2222114-64-7
- US $46.00-78.00 / mg
- TargetMol Chemicals Inc.
2222114-64-7(1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester)Related Search:
1-Piperidinecarboxylic acid, 3-(4-hydroxyphenyl)-2,6-dioxo-, 1,1-dimethylethyl ester
Tert-butyl 4-(4-aMino-3-Methoxyphenyl)piperazine-1-carboxylate
tert-butyl (S)-3-(cyanomethyl)piperazine-1-carboxylate
1-Piperidinecarboxylic acid, 3-(4-amino-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,6-dioxo-, 1,1-dimethylethyl ester
tert-Butyl 2,6-dioxo-3-(4-(prop-2-yn-1-yloxy)phenyl)piperidine-1-carboxylate
4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid,
1-Piperidinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1Hisoindol-5-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid,
4H-Pyrazolo[1,5-a][1,4]diazepine-5(6H)-carboxylic acid, 7,8-dihydro-3-iodo-, 1,1-dimethylethyl ester
tert-butyl 4-((7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
1of3
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate
Thalidomide-piperazine-Boc
Thalidomide-5-piperazine-Boc
2222114-64-7
chem-chemical
