ChemicalBook >> CAS DataBase List >>Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy-

Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy-

Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy- structure

CAS No.: 2414254-34-3

Chemical Name:: Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy-

Synonyms: Exatecan-amide-cyclopropanol;Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy-

CBNumber:: CB68364227

Molecular Formula:: C28H26FN3O6

Molecular Weight:: 519.52

MDL Number:

MOL File:: 2414254-34-3.mol

Last updated:2025-04-17 18:22:24

Request For Quotation

Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy- Properties

Boiling point	974.2±65.0 °C(Predicted)
Density	1.58±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C, away from moisture
solubility	DMSO : 2.73 mg/mL (5.25 mM; ultrasonic and warming and heat to 80°C)
pka	11.18±0.40(Predicted)
form	Solid
color	Light yellow to yellow

Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy- Chemical Properties,Uses,Production

Uses

Exatecan-amide-cyclopropanol (compound 1) is a anticancer agent. Exatecan-amide-cyclopropanol shows anti-proliferation activity against SK-BR-3 and U87 cells, with IC50 values of 0.12 and 0.23 nM, respectively[1].

IC 50

Camptothecins

References

[1] Xu Jianyan, et al. Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof. WO2020063676A1.

Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Chenrui Biotechnology Co. LTD	17625585511	1580084073@qq.com	China	916	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
SuZhou GoodChemTech Co., Ltd	18136139868; 18136139868	jinlun@goodchemtech.cn	China	273	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29545	58

Supplier	Advantage
Suzhou Chenrui Biotechnology Co. LTD	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
SuZhou GoodChemTech Co., Ltd	58
TargetMol Chemicals Inc.	58

Cyclopropanecarboxamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-1-hydroxy- Exatecan-amide-cyclopropanol 2414254-34-3