Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester
![Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester Structure](CAS/20210305/GIF/1414265-81-8.gif)
- CAS No.
- 1414265-81-8
- Chemical Name:
- Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester
- Synonyms
- 6-VIC;VIC2 Phosphoramidite;6-VIC phosphoramidite;SG548 Phosphoramidite;Vinylic indoline (VIC);Benzyl 4-O-(2-Acetamido-2-Deoxy-3,4,6-Tri-O-Acetyl-,-D-Glucopyranosl) -N-Acetyl- -D-Muramic Acid, Methyl Ester;2',4,7-Trichloro-6-((6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-3-oxo-7'-phenyl-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate);2',4,7-trichloro-6-((6-(((2-cyanoethoxy)(diisopropylamino)phosphanyl)oxy)hexyl)carbamoyl)-3-oxo-7'-phenyl-3H-spiro [isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethyl propanoate);Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester
- CBNumber:
- CB68778183
- Molecular Formula:
- C52H59Cl3N3O10P
- Molecular Weight:
- 1023.37
- MDL Number:
- MOL File:
- 1414265-81-8.mol
- MSDS File:
- SDS
Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester Properties
| Boiling point | 940.7±65.0 °C(Predicted) |
|---|---|
| pka | 12.79±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| Appearance | white or off white solid |
| InChIKey | WNXGKJMDPRPEFO-UHFFFAOYSA-N |
| SMILES | C12(C3=C(C=C(OC(=O)C(C)(C)C)C(C4=CC=CC=C4)=C3)OC3=C1C=C(Cl)C(OC(=O)C(C)(C)C)=C3)C1=C(C(Cl)=CC(C(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N)=C1Cl)C(=O)O2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0867313 | VIC phosphoramidite, 6-isomer 98.52% | 1414265-81-8 | 5mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-0867313 | VIC phosphoramidite, 6-isomer 98.52% | 1414265-81-8 | 10mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0867313 | VIC phosphoramidite, 6-isomer 98.52% | 1414265-81-8 | 25mg | $184 | 2026-06-04 | Buy |
| ChemScene | CS-0867313 | VIC phosphoramidite, 6-isomer 98.52% | 1414265-81-8 | 50mg | $292 | 2026-06-04 | Buy |
| ChemScene | CS-0867313 | VIC phosphoramidite, 6-isomer 98.52% | 1414265-81-8 | 100mg | $471 | 2026-06-04 | Buy |
Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester Chemical Properties, Uses, Production
Description
VIC is an asymmetrical xanthene dye (two flanking rings are not the same). This dye is used for the design of qPCR probes. The spectral properties of VIC are similar to HEX and JOE.
This phosphoramidite reagent allows to introduce the label onto 5'-terminus of the oligonucleotide.
Coupling: 10 minutes.
Deprotection: standard conditions with ammonium hydroxide; AMA (solution of 30% ammonium hydroxide/40% aqueous methylamine 1:1 v/v) (15 minutes at 65°C) can be used with minor side product forming.
Uses
VIC phosphoramidite, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end[1].
References
[1] de Kok JB, et al. Rapid genotyping of single nucleotide polymorphisms using novel minor groove binding DNA oligonucleotides (MGB probes). Hum Mutat. 2002 May;19(5):554-9. DOI:10.1002/humu.10076
Abs/Em Maxima
525/546 nm
Fluoresene quantum yield
0.53
Extinction Coefficient
103000
CF260
0.07
CF280
0.07
Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester Preparation Products And Raw materials
Raw materials
Preparation Products
Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7-trichloro-3-oxo-7'-phenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangdong Prochem Biotechnology Co. , Ltd. | 4000707101 | research@prochembio.com | China | 133 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29090 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Jiangsu Synthgene Biotechnology Co.,Ltd. | 15852554546 | starre@syngenebio.com | China | 901 | 58 |
| Hu' nan Yunbang Pharmaceutical Co., Ltd. | 88532689 15386497078 | yunbang@yunbangapi.com | China | 6935 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Nanjing GoodGene Biotechnology Co., Ltd | 13335632219 | 3152731197@qq.com | China | 351 | 58 |
| Zhengzhou Converging Chemical Co. LTD | 0371-53399770 18037166334 | 3857571523@qq.com | China | 7198 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 9067 | 58 |
