Etofenamate
- CAS No.
- 30544-47-9
- Chemical Name:
- Etofenamate
- Synonyms
- ester;EtofenamateEtofenamate;ReuMon;TV-485;Rheumon;TVX-485;CS-1431;Bayrogel;Etofenate;Etofenamate
- CBNumber:
- CB6883241
- Molecular Formula:
- C18H18F3NO4
- Molecular Weight:
- 369.33
- MDL Number:
- MFCD00242806
- MOL File:
- 30544-47-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 25°C |
|---|---|
| Boiling point | bp.001 130-135° |
| Density | 1.2866 (estimate) |
| refractive index | nD25 1.564 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate. |
| pka | 14.32±0.10(Predicted) |
| form | Oil |
| color | Light yellow to yellow |
| Stability | Light Sensitive |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2 |
| InChIKey | XILVEPYQJIOVNB-UHFFFAOYSA-N |
| SMILES | C(OCCOCCO)(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 |
| FDA UNII | KZF0XM66JC |
| ATC code | M02AA06 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H410 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| RIDADR | UN2810 - class 6.1 - PG 3 - EHS - Toxic, liquids, organic, n.o.s., HI: all | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 |
|||||||||
| Toxicity | LD50 in male, female rats (mg/kg): 292, 470 orally; 140, 226 i.v.; 373, 397 i.p.; 643, 568 s.c. (Jacobi) | |||||||||
| NFPA 704 |
|
Etofenamate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E2499901 | Etofenamate for peak identification European Pharmacopoeia (EP) Reference Standard | 30544-47-9 | 20 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | E2499900 | Etofenamate European Pharmacopoeia (EP) Reference Standard | 30544-47-9 | 50 mg | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | E2499901 | Etofenamate for peak identification European Pharmacopoeia (EP) Reference Standard | 30544-47-9 | e2499901 | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | E2499900 | Etofenamate European Pharmacopoeia (EP) Reference Standard | 30544-47-9 | e2499900 | $150 | 2024-03-01 | Buy |
| TCI Chemical | E1551 | Etofenamate min. 98.0 % | 30544-47-9 | 250MG | $214 | 2026-04-30 | Buy |
Etofenamate Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Oil
Originator
Rheumon,Troponwerke,W. Germany,1977
Uses
As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.
Definition
ChEBI: 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester.
Manufacturing Process
16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)- anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to 110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added. The reaction mixture is then heated to boiling for 2 hours. The precipitated potassium chloride is filtered off and the solvent is removed by evaporation. The residue is separated over a column with 400 g of silica gel (particle size 0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3- trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale yellow oil which does not crystallize and cannot be distilled.
Therapeutic Function
Antiinflammatory
Etofenamate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaoxing Hongda Medical Technology Co.,Ltd | 18072995930 | sales001@hongdabova.com | China | 26 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Zhejiang Qiming Pharmaceutical Co., Ltd. | +86-571-87163895 +86-571-87163893 | sales@qimingpharm.com | China | 87 | 65 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 |
View Lastest Price from Etofenamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Etofenamate USP/EP/BP
30544-47-9
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-08 | Etofenamate
30544-47-9
|
$29.00 | 99.97% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-04 | Etofenamate
30544-47-9
|
$5.00 | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- Etofenamate USP/EP/BP
30544-47-9
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Etofenamate
30544-47-9
- $29.00
- 99.97%
- TargetMol Chemicals Inc.
-
- Etofenamate
30544-47-9
- $5.00
- 99%
- Career Henan Chemical Co
