3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid
- CAS No.
- 2458-08-4
- Chemical Name:
- 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid
- Synonyms
- 12-Oxocholic acid;12-Ketochenodeoxycholic acid;Einecs 219-542-6;Ursodiol Impurity;Cholic Acid Impurity 16;1,3-dimethyl-38-nitrosourea;Ursodeoxycholic Acid Impurity 23;Chenodeoxycholic Acid Impurity 10;3,7-Dihydroxy-12-oxocholanoic acid;3α,7α-Dihydroxy-12-oxocholanic acid
- CBNumber:
- CB6890359
- Molecular Formula:
- C24H38O5
- Molecular Weight:
- 406.56
- MDL Number:
- MFCD00134876
- MOL File:
- 2458-08-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 12-keto Chenodeoxycholic Acid ≥95% | 30838 | 1mg | $32 |
| 12-keto Chenodeoxycholic Acid ≥95% | 30838 | 5mg | $145 |
| 12-keto Chenodeoxycholic Acid ≥95% | 30838 | 10mg | $256 |
| 12-keto Chenodeoxycholic Acid ≥95% | 30838 | 25mg | $559 |
| (3a,5b,7a)-3,7-Dihydroxy-12-oxo-cholan-24-oic acid | CAA45808 | 2mg | $150 |
| More product size | |||
| Boiling point | 583℃[at 101 325 Pa] |
|---|---|
| Density | 1.18[at 20℃] |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | -20°C |
| solubility |
Chloroform: Slightly Soluble Methanol: Slightly Soluble |
| pka | 5[at 20 ℃] |
| form | Solid |
| color | White to off-white |
| Water Solubility | 4.698mg/L at 25℃ |
| LogP | 2.97 at 20℃ |
| FDA UNII | 3MKE33N44O |
| UNSPSC Code | 12352211 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| REACH Registrations | Active |
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30838 | 12-keto Chenodeoxycholic Acid ≥95% | 2458-08-4 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 30838 | 12-keto Chenodeoxycholic Acid ≥95% | 2458-08-4 | 5mg | $145 | 2026-04-30 | Buy |
| Cayman Chemical | 30838 | 12-keto Chenodeoxycholic Acid ≥95% | 2458-08-4 | 10mg | $256 | 2026-04-30 | Buy |
| Cayman Chemical | 30838 | 12-keto Chenodeoxycholic Acid ≥95% | 2458-08-4 | 25mg | $559 | 2026-04-30 | Buy |
| Biosynth | CAA45808 | (3a,5b,7a)-3,7-Dihydroxy-12-oxo-cholan-24-oic acid | 2458-08-4 | 2mg | $150 | 2026-06-04 | Buy |
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid Chemical Properties,Uses,Production
Uses
12-Ketochenodeoxycholic acid 12 is a direct precursor of cholodeoxycholic acid (CDCA). Cholodeoxycholic acid is used to cholesterol gallstones and has chemotherapeutic properties that dissolve gallstones[1].
Definition
ChEBI: 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanic acid is an oxo-5beta-cholanic acid. It is a conjugate acid of a 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate.
Flammability and Explosibility
Non flammable
References
[1] Sawada, H. et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid. European Journal of Applied Microbiology and Biotechnology, 10(1–2), 107–112.
[2] J D SUTHERLAND T P F I A Macdonald. The enzymic and chemical synthesis of ursodeoxycholic and chenodeoxycholic acid from cholic acid.[J]. Preparative biochemistry, 1982, 12 4: 307-321. DOI: 10.1080/00327488208065679
[3] A. HOFMANN. The Preparation of Chenodeoxycholic Acid and Its Glycine and Taurine Conjugates.[J]. Acta chemica Scandinavica, 1963, 177 1: 173-186. DOI: 10.3891/acta.chem.scand.17-0173
[4] AIHUA ZHAO. Increased levels of conjugated bile acids are associated with human bile reflux gastritis.[J]. Scientific Reports, 2020: 11601. DOI: 10.1038/s41598-020-68393-5
[5] YIZHONG WANG. Altered gut microbiota and microbial metabolism in children with hepatic glycogen storage disease: a case-control study.[J]. Translational pediatrics, 2023, 12 4: 572-586. DOI: 10.21037/tp-22-293
[6] MOMIR MIKOV. 3Alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate as blood-brain barrier permeator.[J]. Polish journal of pharmacology, 2004, 56 3: 367-371.
[7] MIHALJ POSA. Effect of cholic acid and its keto derivatives on the analgesic action of lidocaine and associated biochemical parameters in rats.[J]. European Journal of Drug Metabolism and Pharmacokinetics, 2007, 32 2: 109-117. DOI: 10.1007/bf03190999
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39988 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16100 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7241 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4794 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18190 | 56 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939; 15221275939 | shenlinxing@macklin.cn | China | 15781 | 55 |
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