ZZW-115 hydrochloride
- CAS No.
- 10122-45-9
- Chemical Name:
- ZZW-115 hydrochloride
- Synonyms
- ZZW-115 hydrochloride;ZZW-115 trihydrochloride;ZZW-115 hydrochloride, 10 mM in DMSO;1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-, hydrochloride (1:3);necroptosis,cell,PDAC,growth,ZZW-115,pancreatic,ZZW115 hydrochloride,ZZW 115 hydrochloride,cancer,ZZW 115,ZZW115,inhibit,ROS,ATP,Inhibitor,Apoptosis
- CBNumber:
- CB69041617
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD32858302
- MOL File:
- Mol file
ZZW-115 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3601 | ZZW-115 trihydrochloride ≥98% (HPLC) | 10122-45-9 | 10MG | $199 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3601 | ZZW-115 trihydrochloride ≥98% (HPLC) | 10122-45-9 | 50MG | $799 | 2024-03-01 | Buy |
| AK Scientific | AMTA197 | ZZW-115hydrochloride | 10122-45-9 | 5mg | $147 | 2021-12-16 | Buy |
ZZW-115 hydrochloride Chemical Properties,Uses,Production
Uses
ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a Kd of 2.1 μM. ZZW-115 hydrochloride induces tumor cell death by necroptosis and apoptosis. Anticancer activity[1][2].
Biological Activity
ZZW-115 is a nuclear protein 1 (NUPR1) inhibitor th at suppresses NUPR1-dependent cancer growth in vitro (IC50 from 0.84 μM/ANOR to 4.93 μM/HN14 among 11 pancreatic ductal adenocarcinoma cultures) and in mice in vivo (5 mg/kg q.d. or q.a.d. via i.p.) via necroptosis and ferroptosis induction. ZZW-115 blocks importins-mediated NUPR1 nuclear translocation by directly targeting NUPR1 nuclear location signal (NLS) region (Kd = 2.1 μM by calorimetric titration).
in vivo
ZZW-115 hydrochloride (0.5-5 mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors[1].
?
ZZW-115 hydrochloride (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases[1].
| Animal Model: | NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells [1] |
| Dosage: | 5, 2.5, 1.0, or 0.5 mg/kg |
| Administration: | Injection; daily for 30 days |
| Result: | When the mice were injected with 5 mg/kg ZZW-115 hydrochloride, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment. |
References
[1] Santofimia-Casta?o P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28. DOI:10.1172/JCI127223
[2] Santofimia-Casta?o P, et al. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells. 2019;8(11):1453. Published 2019 Nov 17. DOI:10.3390/cells8111453
ZZW-115 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
ZZW-115 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1929 | 55 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 1000 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4486 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9998 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29772 | 58 |
View Lastest Price from ZZW-115 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-26 | ZZW-115 hydrochloride
10122-45-9
|
US $84.00-313.00 / mg | 99.95% | 10g | TargetMol Chemicals Inc. |
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- ZZW-115 hydrochloride
10122-45-9
- US $84.00-313.00 / mg
- 99.95%
- TargetMol Chemicals Inc.