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ChemicalBook >> CAS DataBase List >>4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]-

4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]-

4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- Structure
4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- structure
CAS No.
2360853-16-1
Chemical Name:
4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]-
Synonyms
RBN-3143, 10 mM in DMSO;4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]-
CBNumber:
CB69278815
Molecular Formula:
C22H28FN3O4S
Molecular Weight:
449.54
MDL Number:
MOL File:
2360853-16-1.mol
Last updated:2025-09-28 10:37:47
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4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- Properties

Boiling point 645.4±65.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
pka -0.61±0.20(Predicted)
form Solid
color Light yellow to yellow

4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- Chemical Properties,Uses,Production

Uses

RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation[1].

in vivo

RBN-3143 (5 μg; intranasal administration) can improve steroid-resistant asthma mouse models[1].

Animal Model:Mouse of asthma models[1]
Dosage:5 ug
Administration:Intranasal administration
Result:Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.

IC 50

PARP14: 4 nM (IC50); PARP10: 1600 nM (IC50); PARP15: 4200 nM (IC50); PARP4: 42700 nM (IC50); PARP3: >100000 nM (IC50); PARP2: >100000 nM (IC50); PARP1: >100000 nM (IC50)

References

[1] Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal?2022?60:?4642.

4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- Suppliers

Global( 15)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 309 55
Shanghai Maruhua Science and Technology Co. Ltd. 021-57171708; 18721745940 sales2@api-chem.com China 1966 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 997 58
Hebei Weite Medical Technology Co., Ltd 13180081292 contact@wetogethermed.com China 7979 58
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 sales@chemhifuture.com China 3210 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Beijing Huiyue Technology Co., Ltd 17710807091 1210335793@qq.com China 240 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Shanghai XingMo Biotechnology Co., Ltd. 55
Shanghai Maruhua Science and Technology Co. Ltd. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Hebei Weite Medical Technology Co., Ltd 58
Nantong Hi-Future Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Beijing Huiyue Technology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from 4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RBN-3143 pictures 2025-09-28 RBN-3143
2360853-16-1
 US $61.00-233.00 / mg 98.93% 10g TargetMol Chemicals Inc.
  • RBN-3143 pictures
  • RBN-3143
    2360853-16-1
  • US $61.00-233.00 / mg
  • 98.93%
  • TargetMol Chemicals Inc.

4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- Spectrum

4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]-(2360853-16-1)1HNMR
4(3H)-Quinazolinone, 7-[(1-acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]- RBN-3143, 10 mM in DMSO 2360853-16-1