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Sunvozertinib

Sunvozertinib Structure
Sunvozertinib structure
CAS No.
2370013-12-8
Chemical Name:
Sunvozertinib
Synonyms
Sunvozertinib;Sunvozertinib, 10 mM in DMSO;N-{5-({4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl}amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide;(R)-N-(5-((4-((5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-
CBNumber:
CB69757433
Molecular Formula:
C29H35ClFN7O3
Molecular Weight:
584.08
MDL Number:
MOL File:
2370013-12-8.mol
Last updated:2025-10-29 15:43:00
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Sunvozertinib Properties

Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 12.29±0.70(Predicted)
form Solid
color Off-white to light brown
InChIKey BTMKEDDEMKKSEF-QGZVFWFLSA-N
SMILES C(NC1=CC(NC2=NC=CC(NC3=CC(Cl)=C(F)C=C3C(O)(C)C)=N2)=C(OC)C=C1N1CC[C@@H](N(C)C)C1)(=O)C=C
FDA UNII L1Q2K5JYO8

Sunvozertinib Chemical Properties,Uses,Production

Description

Sunvozertinib, also known as DZD9008, is an oral, potent, irreversible, and selective EGFR tyrosine kinase inhibitor. Sunvozertinib shows activity against EGFRexon20ins and other mutations. In both cell lines and xenograft models, sunvozertinib shows potent antitumor activity. In the two ongoing phase I clinical studies, sunvozertinib was tolerated up to 400 mg once daily.

Uses

Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52)[1].

IC 50

EGFR exon 20 insertion: 20.4 nM (IC50); EGFRL858R/T790M: 1.1 nM (IC50); Her2 Exon20 YVMA: 7.5 nM (IC50)

References

[1] Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.

Sunvozertinib Preparation Products And Raw materials

Raw materials

Preparation Products

Sunvozertinib Suppliers

Global( 46)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		+8618235132063 sales@tihondan.com China 3767 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332 Lucky@hanhonggroup.com China 5844 58
Chongqing jooe co., ltd 		+undefined86-15223382610 info@jooe.com China 15976 58
Guangzhou Biocar Biotechnology Co.,Ltd. +86-13397196830 carrie@gzbiocar.cn China 435 58
Jiangsu Magic Biotechnology Co., Ltd 13921770081 svp01@magicbiotech.cn China 499 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 18971495150; sales@sun-shinechem.com China 1112 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185; sales-cpd@caerulumpharma.com China 3505 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		58
Shanghai Hanhong Scientific Co., Ltd. 		58
Chongqing jooe co., ltd 		58
Guangzhou Biocar Biotechnology Co.,Ltd. 58
Jiangsu Magic Biotechnology Co., Ltd 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 58

View Lastest Price from Sunvozertinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sunvozertinib pictures 2022-12-29 Sunvozertinib
2370013-12-8
 US $399.00-398.00 / g 1g 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customized packaging 1kg Guangzhou Biocar Biotechnology Co.,Ltd.
  • Sunvozertinib pictures
  • Sunvozertinib
    2370013-12-8
  • US $399.00-398.00 / g
  • 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customized packaging
  • Guangzhou Biocar Biotechnology Co.,Ltd.

Sunvozertinib Spectrum

Sunvozertinib(2370013-12-8)1HNMR
2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]- Sunvozertinib (R)-N-(5-((4-((5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide Sunvozertinib, 10 mM in DMSO N-{5-({4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl}amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide 2370013-12-8