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PROTAC IRAK4 degrader-2

PROTAC IRAK4 degrader-2 Structure
PROTAC IRAK4 degrader-2 structure
CAS No.
2374122-27-5
Chemical Name:
PROTAC IRAK4 degrader-2
Synonyms
PROTAC IRAK4 degrader-2;1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-4-{3-[9-(5-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}pyrimidin-2-yl)-3,9-diazaspiro[5.5]undecan-3-yl]prop-1-yn-1-yl}-7-methoxyisoquinoline-6-carboxamide
CBNumber:
CB69762017
Molecular Formula:
C57H68FN11O8S
Molecular Weight:
1086.29
MDL Number:
MOL File:
2374122-27-5.mol
Last updated:2025-04-18 09:52:34
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PROTAC IRAK4 degrader-2 Properties

Density 1.40±0.1 g/cm3(Predicted)
pka 12.36±0.46(Predicted)

PROTAC IRAK4 degrader-2 Chemical Properties, Uses, Production

Uses

PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC50 of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs[1].

IC 50

IRAK4

References

[1] Joao Nunes, et al. Targeting IRAK4 for Degradation with PROTACs. ACS Med Chem Lett. 2019 Jun 14;10(7):1081-1085. DOI:10.1021/acsmedchemlett.9b00219

PROTAC IRAK4 degrader-2 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC IRAK4 degrader-2 Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
Supplier Advantage
Jilin Province Woda Biotechnology Co., Ltd. 58

2374122-27-5 (PROTAC IRAK4 degrader-2) Related Search:

INDEX NAME NOT YET ASSIGNED 2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]methyl]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- 2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- 2-Pyridinecarboxamide, N-[2-[trans-4-[[[3-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]propyl]methylamino]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- 2-Pyridinecarboxamide, 6-(1,1-difluoroethyl)-N-[2-[trans-4-[[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-methoxy-2H-indazol-5-yl]-
2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-

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PROTAC IRAK4 degrader-2 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-4-{3-[9-(5-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}pyrimidin-2-yl)-3,9-diazaspiro[5.5]undecan-3-yl]prop-1-yn-1-yl}-7-methoxyisoquinoline-6-carboxamide 2374122-27-5