[1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]-
![[1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]- Structure](CAS/20210305/GIF/1359415-02-3.gif)
- CAS No.
- 1359415-02-3
- Chemical Name:
- [1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]-
- Synonyms
- UBE2T/FANCL-IN-1;[1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]-
- CBNumber:
- CB69833685
- Molecular Formula:
- C19H31N7
- Molecular Weight:
- 357.5
- MDL Number:
- MOL File:
- 1359415-02-3.mol
- MSDS File:
- SDS
[1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0105168 | UBE2T/FANCL-IN-1 99.83% | 1359415-02-3 | 5mg | $542 | 2026-06-04 | Buy |
| ChemScene | CS-0105168 | UBE2T/FANCL-IN-1 99.83% | 1359415-02-3 | 10mg | $867 | 2026-06-04 | Buy |
| ChemScene | CS-0105168 | UBE2T/FANCL-IN-1 99.83% | 1359415-02-3 | 25mg | $1733 | 2026-06-04 | Buy |
| ChemScene | CS-0105168 | UBE2T/FANCL-IN-1 99.83% | 1359415-02-3 | 50mg | $2817 | 2026-06-04 | Buy |
| ChemScene | CS-0105168 | UBE2T/FANCL-IN-1 99.83% | 1359415-02-3 | 100mg | $4550 | 2026-06-04 | Buy |
[1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]- Chemical Properties, Uses, Production
Uses
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].
Biological Activity
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1]. UBE2T/FANCL-IN-1 (CU2) completely inhibits the ubiquitylation of GST-FANCLRING at 100 μM. UBE2T/FANCL-IN-1 (500 μM) reduced the level of mUb-FANCD2 in response to HU treatment. UBE2T/FANCL-IN-1 (500 μM) also reducesthe level of mUb-FANCD2 generated in response to Cisplatin (10 μM) treatment for 6, 12, and 24 hours. The combination of 250 μM UBE2T/FANCL-IN-1 with 15 μM carboplatin led to an even more pronounced decrease in cell proliferation/growth, with the cells being <50% confluent after 8 days[1].
References
[1]. Cornwell MJ, et al. Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway. ACS Chem Biol. 2019;14(10):2148-2154.
[1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
[1,2,4]Triazolo[1,5-a]pyrimidine, 7-(4-ethyl-1-piperazinyl)-5-methyl-2-[(2-methyl-1-piperidinyl)methyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Shanghai Merlot Chemical Co., LTD | 15821661757 | 226174156@qq.com | China | 476 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
