7-ETHYLISATIN
- CAS No.
- 79183-65-6
- Chemical Name:
- 7-ETHYLISATIN
- Synonyms
- NSC61828;ALD-N000069;7-Ethylisatin;7-Ethylindoline-2,3-dione;7-Ethyl-1H-indol-2,3-dione;7-Ethyl-1H-indole-2,3-dione;1H-Indole-2,3-dione,7-ethyl-;7-Ethyl-1H-indole-2,3-dione >98%;7-ethyl-2,3-dihydro-1H-indole-2,3-dione;7-ethyl-1H-indole-2,3-dione(SALTDATA: FREE)
- CBNumber:
- CB71010946
- Molecular Formula:
- C10H9NO2
- Molecular Weight:
- 175.18
- MDL Number:
- MFCD00047222
- MOL File:
- 79183-65-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 7-ETHYLISATIN 97% | 61516 | 1G | $144 |
| 7-ETHYLISATIN 97% | 61516 | 5G | $679 |
| 7-Ethylisatin 95% | OR952606 | 1g | $198 |
| 7-Ethylisatin 95% | OR952606 | 5g | $776 |
| 7-Ethylisatin 95% | OR952606 | 1g | $198 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
7-ETHYLISATIN price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 61516 | 7-ETHYLISATIN 97% | 79183-65-6 | 1G | $144 | 2026-04-30 | Buy |
| AstaTech | 61516 | 7-ETHYLISATIN 97% | 79183-65-6 | 5G | $679 | 2026-04-30 | Buy |
| Apolloscientific | OR952606 | 7-Ethylisatin 95% | 79183-65-6 | 1g | $198 | 2026-06-04 | Buy |
| Apolloscientific | OR952606 | 7-Ethylisatin 95% | 79183-65-6 | 5g | $776 | 2026-06-04 | Buy |
| Apolloscientific | OR952606 | 7-Ethylisatin 95% | 79183-65-6 | 1g | $198 | 2026-06-04 | Buy |
7-ETHYLISATIN Chemical Properties,Uses,Production
Uses
7-Ethyl-1H-indole-2,3-dione is used in the synthetic preparation of substituted indolin-2-ones as p90 ribosomal s6 protein kinase 2 (RSK2) inhibitors.
Synthesis
7509-61-7
79183-65-6
Intermediate 62 was ground as described by Yang et al. (see J. Am. Chem. Soc., 1996, 118:9557) and added in portions to a 50 mL conical flask containing 15 mL of concentrated sulfuric acid while maintaining stirring and maintaining the temperature at 90°C. Acetamide was added slowly, ensuring that the temperature of the reaction mixture did not exceed 105 °C. After addition, the purple-black solution was continued to be stirred at 90°C for 15 minutes, subsequently cooled to 60°C and poured into a beaker containing 15 g of crushed ice. Ice was continued to be added until the outside of the beaker was cold to the touch. The orange-brown precipitate was collected by filtration and dried overnight under vacuum to afford dihydroindole-2,3-dione (Intermediate 63, 0.77 g, 27% yield) of sufficient purity for use in the next step. Intermediate 63 was also recrystallized from ethanol to give a pure orange-red needle product.1H NMR (400 MHz, DMSO-d6) δ 1.14 (t, J = 7.5 Hz, 3H), 2.56 (q, J = 7.6 Hz, 2H), 7.03 (t, J = 7.5 Hz, 1H), 7.35 (d, J = 7.3 Hz, 1H), 7.46 (d , J = 7.6 Hz, 1H), 11.11 (s, 1H).
References
[1] Bulletin of the Chemical Society of Japan, 2006, vol. 79, # 10, p. 1585 - 1600
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 3, p. 628 - 630
[3] Patent: US2008/255192, 2008, A1. Location in patent: Page/Page column 22-23
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 6003 - 6017
[5] Journal of Organic Chemistry, 2018, vol. 83, # 15, p. 7622 - 7632
7-ETHYLISATIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 | info@afinechem.com | China | 15083 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Hangzhou Milon Pharmatech Co.,Ltd. | +8618083715844 | sales02@milonpharm.com | China | 331 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
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