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2-Methyl-6-nitrobenzoxazole

2-Methyl-6-nitrobenzoxazole Structure
2-Methyl-6-nitrobenzoxazole structure
CAS No.
5683-43-2
Chemical Name:
2-Methyl-6-nitrobenzoxazole
Synonyms
2-METHYL-6-NITROBENZOXAZOLE;Benzoxazole, 2-methyl-6-nitro-;2-Methyl-6-nitrobenzo[d]oxazole;2-METHYL-6-NITRO-1,3-BENZOXAZOLE
CBNumber:
CB7103281
Molecular Formula:
C8H6N2O3
Molecular Weight:
178.14
MDL Number:
MFCD00022848
MOL File:
5683-43-2.mol
MSDS File:
SDS
Last updated:2026-05-28 03:26:10
Product description Number Pack Size Price
2-Methyl-6-nitro-1,3-benzoxazole 98% OR110718 5g $21
2-Methyl-6-nitro-1,3-benzoxazole 98% OR110718 100g $151
2-Methyl-6-nitro-1,3-benzoxazole 043320 500.00mg $118
2-Methyl-6-nitro-1,3-benzoxazole 043320 1.00g $151
2-Methyl-6-nitro-1,3-benzoxazole 043320 5.00g $346
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2-Methyl-6-nitrobenzoxazole Properties

Melting point 157-158°C
Boiling point 303.1±15.0 °C(Predicted)
Density 1.395±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka -1.45±0.30(Predicted)
Appearance Off-white to light yellow Solid
Water Solubility Soluble in oils. Insoluble in water.
CAS DataBase Reference 5683-43-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36/37/39
HazardClass  IRRITANT
HS Code  2934999090
NFPA 704
1
2 0

2-Methyl-6-nitrobenzoxazole price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR110718 2-Methyl-6-nitro-1,3-benzoxazole 98% 5683-43-2 5g $21 2026-06-04 Buy
Apolloscientific OR110718 2-Methyl-6-nitro-1,3-benzoxazole 98% 5683-43-2 100g $151 2026-06-04 Buy
Matrix Scientific 043320 2-Methyl-6-nitro-1,3-benzoxazole 5683-43-2 500.00mg $118 2026-05-18 Buy
Matrix Scientific 043320 2-Methyl-6-nitro-1,3-benzoxazole 5683-43-2 1.00g $151 2026-05-18 Buy
Matrix Scientific 043320 2-Methyl-6-nitro-1,3-benzoxazole 5683-43-2 5.00g $346 2026-05-18 Buy
Product number Packaging Price Buy
OR110718 5g $21 Buy
OR110718 100g $151 Buy
043320 500.00mg $118 Buy
043320 1.00g $151 Buy
043320 5.00g $346 Buy

2-Methyl-6-nitrobenzoxazole Chemical Properties,Uses,Production

Uses

2-Methyl-6-nitrobenzoxazole is used as a flavoring agents.

Synthesis

Acetyl chloride

75-36-5

2-Amino-5-nitrophenol

121-88-0

2-Methyl-6-nitrobenzoxazole

5683-43-2

Scheme 1 outlines the synthetic route to 2-methyl-6-nitrobenzoxazole in the following detailed steps:(a) 2-amino-5-nitrophenol (7.70 g, 50.0 mmol) and pyridine (3.96 g, 50.0 mmol) were dissolved in dry xylene (150 mL) at 0 °C, and acetyl chloride (4.32 g, 55.0 mmol) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, p-toluenesulfonic acid (1.72 g, 10.0 mmol) was added and the mixture was refluxed until no water was drained. After cooling to room temperature, the organic layer was washed sequentially with water (100 mL x 3) and saturated NaCl solution (50.0 mL). The organic phase was collected, dried with Na2SO4, and the solvent was evaporated under reduced pressure to afford the crude product 2-methyl-6-nitrobenzoxazole (light-colored solid, 8.80 g, 95% yield), which could be used in the next reaction without further purification. (b) 2-Methyl-6-nitrobenzoxazole (3.92 g, 22.0 mmol) was dissolved in methanol (60.0 mL) and a solution of NH4Cl (11.77 g, 220 mmol) in water (40.0 mL) and iron powder (4.48 g, 80.0 mmol) was added. The mixture was stirred at 70 °C for 4 h until the feedstock was completely consumed (TLC monitoring). After completion of the reaction, it was cooled to room temperature, filtered and the filtrate was extracted with ethyl acetate (30.0 mL x 3). The organic phases were combined, dried with Na2SO4 and the solvent was evaporated under reduced pressure to give crude 2-methylbenzoxazol-6-amine (2.77 g, 85% yield), which was used directly in the next reaction. (c) 2-Methylbenzoxazol-6-amine (2.66 g, 18.0 mmol) was dissolved in methanol (30.0 mL) and formaldehyde (37%, 12 mL, 144 mmol) and NaBH3CN (2.27 g, 36.0 mmol) were added. The reaction mixture was stirred at room temperature for 36 hours until the feedstock was completely converted (TLC monitoring). The reaction solution was poured into water (30.0 mL) and extracted with ethyl acetate (30.0 mL x 3). The organic phases were combined, dried with Na2SO4, concentrated and purified by fast column chromatography (eluent: petroleum ether/ethyl acetate=10/1, v/v, Rf=0.11) to afford 2-methyl-6-(N,N-dimethylamino)benzoxazole (2.50 g, 79% yield).

References

[1] Journal of Photochemistry and Photobiology A: Chemistry, 2018, vol. 361, p. 62 - 66

2-Methyl-6-nitrobenzoxazole Preparation Products And Raw materials

Raw materials

ACETAMIDE, N-(2-HYDROXY-4-NITROPHENYL)- Acetyl chloride 2-Amino-5-nitrophenol Pyridine 1,3-Cyclohexadiene, 5,5-dimethyl-

Preparation Products

2-Methyl-6-nitrobenzoxazole Suppliers

Global( 109)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-17392587031 1059@dideu.com China 9984 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9036 58
Henan Alfa Chemical Co., Ltd 		+8618339805032 sale03@alfachem.cn China 9857 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9628 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Baoji Guokang Healthchem Co., Ltd. 		58
Henan Alfa Chemical Co., Ltd 		58
changzhou huayang technology co., ltd 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58

View Lastest Price from 2-Methyl-6-nitrobenzoxazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methyl-6-nitrobenzoxazole pictures 2022-01-18 2-Methyl-6-nitrobenzoxazole
5683-43-2
 1KG 97.4% 100 tons Honest Joy Holdings Limited
2-Methyl-6-nitrobenzoxazole pictures 2021-07-13 2-Methyl-6-nitrobenzoxazole
5683-43-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2-Methyl-6-nitrobenzoxazole pictures 2021-07-10 2-Methyl-6-nitrobenzoxazole
5683-43-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Methyl-6-nitrobenzoxazole Spectrum

2-Methyl-6-nitrobenzoxazole(5683-43-2)1HNMR

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2-METHYL-6-NITROBENZOXAZOLE 2-METHYL-6-NITRO-1,3-BENZOXAZOLE Benzoxazole, 2-methyl-6-nitro- 2-Methyl-6-nitrobenzo[d]oxazole 5683-43-2