Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
- CAS No.
- 695-85-2
- Chemical Name:
- Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
- Synonyms
- 4-Chloro-5-methoxypyrimidine;Pyrimidine, 4-chloro-5-methoxy-;Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI);Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) ISO 9001：2015 REACH
- CBNumber:
- CB71045162
- Molecular Formula:
- C5H5ClN2O
- Molecular Weight:
- 144.56
- MDL Number:
- MFCD09966063
- MOL File:
- 695-85-2.mol
| Product description | Number | Pack Size | Price |
| 4-chloro-5-methoxypyrimidine | C373573 | 50mg | $90 |
| 4-Chloro-5-methoxypyrimidine 95% | OR929762 | 100mg | $130 |
| 4-Chloro-5-methoxypyrimidine 95% | OR929762 | 250mg | $235 |
| 4-Chloro-5-methoxypyrimidine 95+% | 089772 | 250mg | $341 |
| 4-CHLORO-5-METHOXYPYRIMIDINE 95.00% | HCH0358908 | 5MG | $503.67 |
| More product size | |||
| Melting point | 63-64℃ |
|---|---|
| Boiling point | 221.9±20.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 0.17±0.16(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C5H5ClN2O/c1-9-4-2-7-3-8-5(4)6/h2-3H,1H3 |
| InChIKey | CTMIYYREUVYVEL-UHFFFAOYSA-N |
| SMILES | C1=NC=C(OC)C(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318-H335 |
| Precautionary statements | P280-P305+P351+P338-P310-P264-P270-P301+P312-P330-P501 |
| HS Code | 2933599590 |
Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C373573 | 4-chloro-5-methoxypyrimidine | 695-85-2 | 50mg | $90 | 2021-12-16 | Buy |
| Apolloscientific | OR929762 | 4-Chloro-5-methoxypyrimidine 95% | 695-85-2 | 100mg | $130 | 2021-12-16 | Buy |
| Apolloscientific | OR929762 | 4-Chloro-5-methoxypyrimidine 95% | 695-85-2 | 250mg | $235 | 2021-12-16 | Buy |
| Matrix Scientific | 089772 | 4-Chloro-5-methoxypyrimidine 95+% | 695-85-2 | 250mg | $341 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0358908 | 4-CHLORO-5-METHOXYPYRIMIDINE 95.00% | 695-85-2 | 5MG | $503.67 | 2021-12-16 | Buy |
Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) Chemical Properties,Uses,Production
Uses
4-Chloro-5-methoxypyrimidine is a heterocyclic compound that can be used as an intermediate in organic synthesis.
Synthesis
695-87-4
695-85-2
The general procedure for the synthesis of 4-chloro-5-methoxypyrimidine from 4-hydroxy-5-methoxypyrimidine was as follows: 5-methoxypyrimidin-4-ol (57 g, 0.452 mol) was suspended in phosphorous triclosan (540 mL) and heated to reflux for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent dichloromethane/methanol = 10:1), and after confirming the completion of the reaction, most of the phosphorous trichloride was evaporated under reduced pressure. The residue was slowly poured into ice water (2 L) and the pH was adjusted with potassium carbonate (250 g) to about 7. Subsequently, the mixture was extracted with ethyl acetate/tert-butyl methyl ether (3:1, 4 x 250 mL). The organic phases were combined, washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-chloro-5-methoxypyrimidine (3S g, 58% yield) as a yellow solid. Its 1H NMR (400 MHz, DMSO-d6) data were as follows: δ 8.63 (s, 1H), 8.32 (s, 1H), 4.02 (s, 3H).
References
[1] Journal of Organic Chemistry, 1997, vol. 62, # 26, p. 9192 - 9202
[2] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 80
[3] Organic Process Research and Development, 2015, vol. 19, # 6, p. 639 - 645
Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8626 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7099 | 58 |
View Lastest Price from Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-25 | Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
695-85-2
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-13 | Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
695-85-2
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
695-85-2
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
695-85-2
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
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