5-BROMOTHIAZOLE-2-CARBOXYLIC ACID
- CAS No.
- 957346-62-2
- Chemical Name:
- 5-BROMOTHIAZOLE-2-CARBOXYLIC ACID
- Synonyms
- 5-bromo-1,3-thiazole-2-carboxylic acid;5-BROMOTHIAZOLE-2-CARBOXYLIC ACID;5-bromo-2-Thiazole carbocylic acid;2-Thiazolecarboxylic acid, 5-bromo-
- CBNumber:
- CB71092782
- Molecular Formula:
- C4H2BrNO2S
- Molecular Weight:
- 208.03
- MDL Number:
- MFCD11521568
- MOL File:
- 957346-62-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromothiazole-2-carboxylic acid 98% | AS56020 | 1g | $185 |
| 5-Bromothiazole-2-carboxylic acid 98% | AS56020 | 5g | $605 |
| 5-Bromothiazole-2-carboxylic acid | 122200 | 250.00mg | $68 |
| 5-Bromothiazole-2-carboxylic acid | 122200 | 1.00g | $200 |
| 5-Bromothiazole-2-carboxylic acid | 122200 | 5.00g | $602 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P280-P305+P351+P338-P337+P313-P261-P271-P304+P340-P311-P403+P233-P273 |
5-BROMOTHIAZOLE-2-CARBOXYLIC ACID price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS56020 | 5-Bromothiazole-2-carboxylic acid 98% | 957346-62-2 | 1g | $185 | 2026-06-04 | Buy |
| Activate Scientific | AS56020 | 5-Bromothiazole-2-carboxylic acid 98% | 957346-62-2 | 5g | $605 | 2026-06-04 | Buy |
| Matrix Scientific | 122200 | 5-Bromothiazole-2-carboxylic acid | 957346-62-2 | 250.00mg | $68 | 2026-05-18 | Buy |
| Matrix Scientific | 122200 | 5-Bromothiazole-2-carboxylic acid | 957346-62-2 | 1.00g | $200 | 2026-05-18 | Buy |
| Matrix Scientific | 122200 | 5-Bromothiazole-2-carboxylic acid | 957346-62-2 | 5.00g | $602 | 2026-05-18 | Buy |
5-BROMOTHIAZOLE-2-CARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
5-Bromo-1,3-thiazol-2-carboxylic acid is a thiazolium derivative used in pharmaceuticals and organic synthesis.
Synthesis
14190-59-1
957346-62-2
The general procedure for the synthesis of 5-bromothiazole-2-carboxylic acid from thiazole-2-carboxylic acid was as follows: thiazole-2-carboxylic acid (1.60 g, 12.4 mmol) was slowly added to dry tetrahydrofuran (THF, 100 mL) in a lithium diisopropylammonium (LDA, 1 M solution of THF/heptane/ethylbenzene, 26.0 mmol, 26 mL) solution. The reaction mixture was stirred at this temperature for 30 min. Subsequently, carbon tetrabromide (CBr4, 4.52 g, 13.6 mmol) was added and the reaction continued to be stirred for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (30 mL). After the mixture was brought to room temperature, it was diluted with saturated sodium bicarbonate (NaHCO3) aqueous solution (50 mL). The mixture was filtered through a diatomaceous earth pad and extracted with ethyl acetate (EtOAc, 50 mL). The organic layer was discarded and the aqueous layer was acidified with 1 M hydrochloric acid (HCl) to an acidic pH. The acidified aqueous solution was extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), and concentrated in vacuum to give 5-bromothiazole-2-carboxylic acid (0.42 g, 2.0 mmol, 16% yield).LCMS analysis: [M + H]+ = 207.90, measured value 208.0.
References
[1] Patent: WO2015/161928, 2015, A1. Location in patent: Page/Page column 36; 53; 54
[2] Patent: WO2015/161924, 2015, A1. Location in patent: Page/Page column 30
5-BROMOTHIAZOLE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
5-BROMOTHIAZOLE-2-CARBOXYLIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2812 | 58 |
