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8-Hydroxyquinaldine

8-Hydroxyquinaldine structure

CAS No.: 826-81-3

Chemical Name:: 8-Hydroxyquinaldine

Synonyms: 2-Methylquinolin-8-ol;2-METHYL-8-QUINOLINOL;2-methyl-8-quinolino;2-METHYL-8-HYDROXYQUINOLINE;8-HYDROXY-2-METHYLQUINOLINE;2-METHYLOXINE;8-HydroxyquinaL;Hydroxyquinaldine;8-Hydroxyqinaldine;2-Methyl-8-hydroxy

CBNumber:: CB7112580

Molecular Formula:: C10H9NO

Molecular Weight:: 159.18

MDL Number:: MFCD00006765

MOL File:: 826-81-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:24:05

Product description	Number	Pack Size	Price
2-Methyl-8-quinolinol 98%	H57602	100g	$77
2-Methyl-8-quinolinol >98.0%(GC)(T)	M0420	25g	$38
2-Methyl-8-quinolinol >98.0%(GC)(T)	M0420	100g	$86
2-Methyl-8-quinolinol >98.0%(GC)(T)	M0420	500g	$318
2-Methylquinolin-8-ol	M329468	500mg	$60
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8-Hydroxyquinaldine Properties

Melting point	71-73 °C(lit.)
Boiling point	267 °C(lit.)
Density	1.1202 (rough estimate)
refractive index	1.6070 (estimate)
Flash point	139°C
storage temp.	Store below +30°C.
solubility	0.4g/l
pka	pK1:5.55(＋1);pK2:10.31(0) (25°C)
form	Crystalline Powder
color	Beige to brown
PH	7-8 (100g/l, H2O, 20℃)(slurry)
Water Solubility	insoluble
BRN	119194
InChI	1S/C10H9NO/c1-7-5-6-8-3-2-4-9(12)10(8)11-7/h2-6,12H,1H3
InChIKey	NBYLBWHHTUWMER-UHFFFAOYSA-N
SMILES	Cc1ccc2cccc(O)c2n1
CAS DataBase Reference	826-81-3(CAS DataBase Reference)
FDA UNII	7W631H5302
NIST Chemistry Reference	8-Quinolinol, 2-methyl-(826-81-3)
EPA Substance Registry System	8-Quinolinol, 2-methyl- (826-81-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS09

Signal word

Warning

Hazard statements

H410

Precautionary statements

P273-P391-P501

PPE

Eyeshields, Gloves

Hazard Codes

N,Xi

Risk Statements

50/53-36/37/38

Safety Statements

60-61-24/25-36-26

RIDADR

UN 3077 9/PG 3

WGK Germany

RTECS

VC7920000

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29334990

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Acute 1
Aquatic Chronic 1

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
1		0

8-Hydroxyquinaldine price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H57602	2-Methyl-8-quinolinol 98%	826-81-3	100g	$77	2025-07-31	Buy
TCI Chemical	M0420	2-Methyl-8-quinolinol >98.0%(GC)(T)	826-81-3	25g	$38	2025-07-31	Buy
TCI Chemical	M0420	2-Methyl-8-quinolinol >98.0%(GC)(T)	826-81-3	100g	$86	2025-07-31	Buy
TCI Chemical	M0420	2-Methyl-8-quinolinol >98.0%(GC)(T)	826-81-3	500g	$318	2022-04-27	Buy
TRC	M329468	2-Methylquinolin-8-ol	826-81-3	500mg	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
H57602	100g	$77	Buy
M0420	25g	$38	Buy
M0420	100g	$86	Buy
M0420	500g	$318	Buy
M329468	500mg	$60	Buy

8-Hydroxyquinaldine Chemical Properties,Uses,Production

Chemical Properties

beige to brown crystalline powder. Soluble in hot alcohol, ether and benzene, insoluble in water. Can volatilize with water vapor and sublimate at 100℃. With phenol odor.

Uses

8-Hydroxyquinaldine is mainly used as metal ion extractant and metal ion determination, also used in the synthesis of dyes and pigments and the preparation of pharmaceutical intermediates.

Preparation

8-hydroxyquinaldine is obtained from the reaction of 2-aminophenol with crotonaldehyde. Mix 2-aminophenol and 2-Nitrophenol homogeneously and add hydrochloric acid. Add crotonaldehyde under stirring. Heat for 6h and leave overnight. Distill the reacted o-nitrophenol by water distillation, and add sodium hydroxide solution to the residual solution to make it weakly basic. Then add powdered carbonyls for saturation, and distill 8-Hydroxyquinaldine by water distillation, and then distill the crude product under reduced pressure and recrystallize it with ethanol to obtain 8-hydroxyquinaldine.

Definition

ChEBI: 2-Methylquinolin-8-ol is a hydroxyquinoline.

Synthesis Reference(s)

Tetrahedron, 52, p. 2937, 1996 DOI: 10.1016/0040-4020(95)01118-8

General Description

2-Methyl-8-quinolinol is a methyl substituted quinolinol derivative that shows fungicidal property. It can also undergo complexation with transition metal complexes.

Purification Methods

Crystallise the quinoline from EtOH or aqueous EtOH. Its solubility at 20o in H2O is 0.366g/L, and in CHCl3 it is 466g/L. It complexes with many metals. [Beilstein 21 H 106, 21 III/IV 2132.]

8-Hydroxyquinaldine synthesis

Synthesis of 8-Hydroxyquinaldine from 8-METHOXY-2-METHYLQUINOLINE

8-Hydroxyquinaldine Preparation Products And Raw materials

Raw materials

Crotonaldehyde (trans predominantly) 2-Nitrophenol 2-Aminophenol

Preparation Products

8-Hydroxyquinoline-2-carboxaldehyde BIS(2-METHYL-8-HYDROXYQUINOLINATO)ZINC 8-hydroxy-2-methylquinoline-7-carboxylic acid 2-Methylquinoline-8-carbonitrile

8-Hydroxyquinaldine Suppliers

Global( 338)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Kaitian Chemical Co., LTD	+86-13337816511 +86-13337835376	kt_chem@126.com	China	91	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29832	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Nanjing Kaitian Chemical Co., LTD	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Springchem New Material Technology Co.,Limited	57
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 8-Hydroxyquinaldine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-16	8-Hydroxyquinaldine 826-81-3	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Kaitian Chemical Co., LTD
2025-06-27	8-Hydroxyquinaldine 826-81-3	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	8-Hydroxyquinaldine 826-81-3	US $20.00-1.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.

8-Hydroxyquinaldine
826-81-3
US $0.00-0.00 / kg
98%
Nanjing Kaitian Chemical Co., LTD

8-Hydroxyquinaldine
826-81-3
US $30.00-10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

8-Hydroxyquinaldine
826-81-3
US $20.00-1.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

8-Hydroxyquinaldine Spectrum

8-Hydroxyquinaldine(826-81-3)MS 8-Hydroxyquinaldine(826-81-3)¹HNMR 8-Hydroxyquinaldine(826-81-3)¹³CNMR 8-Hydroxyquinaldine(826-81-3)IR1 8-Hydroxyquinaldine(826-81-3)IR2 8-Hydroxyquinaldine(826-81-3)Raman

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2-Methylquinolin-8-ol 2-methyl-8-quinolino 8-Hydroxyqinaldine 8-Hydroxyquinaldine,98% 8-Hydroxyquinaldine, 98% 100GR 8-Hydroxyquinaldine, 98% 25GR 8-Hydroxyquinaldine, 98% 500GR 8-Hydroxymethylquinoline 8-Hydroxy-2-methylquinoline 2-Methyloxine 8-Hydroxyquinaldine 2-Methyl-8-hydroxyquinoine 8-Hydroxyquinaldine, 2-Methylquinolin-8-ol 8-Quinolinol,2-methyl- 4-Hydroxy-3-quinoline carboxylic acid 8-Hydroxyquinaldine~2-Methyl-8-quinolinol Hydroxyquinaldine,99% Hydroxyquinaldine 8-HYDROXY-2-METHYLQUINOLINE 8-HYDROXYQUINALDINE 2-METHYL-8-HYDROXYQUINOLINE 2-METHYL-8-QUINOLINOL 2-METHYLOXINE 1-Methyl 8-quinolinol 2-Methyl-8-hydroxy TIMTEC-BB SBB009099 8-HYDROXYQUINALDINE MIN. 98% 8-HYDROXYQUINALDINE 98% 1-methyl-2H-quinolin-8-ol 8-HYDROXYQUINALDINE8-HYDROXYQUINALDINE8-HYDROXYQUINALDINE8-HYDROXYQUINALDINE 2-Methyl-8-quinolinol> 8-Hydroxyquinaldine (8-Hydroxy-2-me 8-HydroxyquinaL 8-Hydroxyquinaldine (8-Hydroxy-2-methylquinoline) 8-Hydroxy-2-methylquinoline 98% Bedaquiline Impurity 125 826-81-3 C9H5NOHCH3 Quinaldines Heterocyclic Building Blocks Hydroxyquinolines Quinolines Alkylquinolines Building Blocks Alkylquinolines Hydroxyquinolines Quinolines Quinolines, Quinazolines and derivatives bc0001