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2-Difluoromethyl-1H-benzoimidazole

2-Difluoromethyl-1H-benzoimidazole structure

CAS No.: 705-09-9

Chemical Name:: 2-Difluoromethyl-1H-benzoimidazole

Synonyms: EOS-60796;2-(Difluoromethyl);2-Difluoromethylbenzimidazole;2-Difluoromethyl-1H-benzoimidazole;2-(Difluoromethyl)-1H-benzimidazole;1H-Benzimidazole, 2-(difluoromethyl)-;2-(difluoroMethyl)-1H-1,3-benzodiazole;Octanedioicacid,3,10-dioxo-,dimethylester;1H-Benzimidazole,2-(difluoromethyl)-(9CI);1H-benzo[d]imidazole, 2-(difluoromethyl)-

CBNumber:: CB71216072

Molecular Formula:: C8H6F2N2

Molecular Weight:: 168.14

MDL Number:: MFCD00463015

MOL File:: 705-09-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
2-(Difluoromethyl)benzimidazole >98.0%(GC)(T)	D4763	1g	$43
2-(Difluoromethyl)benzimidazole >98.0%(GC)(T)	D4763	5g	$130
2-(Difluoromethyl)-1H-benzo[d]imidazole	D452253	50mg	$45
2-(Difluoromethyl)-1H-benzo[d]imidazole	D452253	100mg	$60
2-(Difluoromethyl)-1H-benzimidazole 97%	3H32-3-02	5G	$85
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2-Difluoromethyl-1H-benzoimidazole Properties

Melting point	155.0 to 159.0 °C
Boiling point	57-62 °C(Press: 5 Torr)
Density	1.366±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	10.43±0.10(Predicted)
color	White to Light yellow to Light orange
λmax	276nm(EtOH)(lit.)
InChI	InChI=1S/C8H6F2N2/c9-7(10)8-11-5-3-1-2-4-6(5)12-8/h1-4,7H,(H,11,12)
InChIKey	PURNIHSRWGYONZ-UHFFFAOYSA-N
SMILES	C1(C(F)F)NC2=CC=CC=C2N=1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H317-H319-H335

Precautionary statements

P261-P280-P305+P351+P338

Hazard Codes

HazardClass

IRRITANT

HS Code

2933998090

NFPA 704

	0
2		0

2-Difluoromethyl-1H-benzoimidazole price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4763	2-(Difluoromethyl)benzimidazole >98.0%(GC)(T)	705-09-9	1g	$43	2025-07-31	Buy
TCI Chemical	D4763	2-(Difluoromethyl)benzimidazole >98.0%(GC)(T)	705-09-9	5g	$130	2025-07-31	Buy
TRC	D452253	2-(Difluoromethyl)-1H-benzo[d]imidazole	705-09-9	50mg	$45	2021-12-16	Buy
TRC	D452253	2-(Difluoromethyl)-1H-benzo[d]imidazole	705-09-9	100mg	$60	2021-12-16	Buy
SynQuest Laboratories	3H32-3-02	2-(Difluoromethyl)-1H-benzimidazole 97%	705-09-9	5G	$85	2021-12-16	Buy

Product number	Packaging	Price	Buy
D4763	1g	$43	Buy
D4763	5g	$130	Buy
D452253	50mg	$45	Buy
D452253	100mg	$60	Buy
3H32-3-02	5G	$85	Buy

2-Difluoromethyl-1H-benzoimidazole Chemical Properties,Uses,Production

Synthesis

381-73-7

95-54-5

705-09-9

In a screw cap vial, o-phenylenediamine (1 mmol) was dissolved in difluoroacetic acid (2 mL, 0.5 M) and the reaction mixture was stirred at 70 °C for 16 hours. After completion of the reaction, the difluoroacetic acid was removed by evaporation under reduced pressure and the crude product was purified by silica gel column chromatography to afford 2-(difluoromethyl)-1H-benzo[d]imidazole.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 3, p. 201 - 204
[2] Patent: US2007/244110, 2007, A1. Location in patent: Page/Page column 4
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 2, p. 206 - 210
[4] Tetrahedron Letters, 2007, vol. 48, # 18, p. 3251 - 3254
[5] Patent: WO2013/123634, 2013, A1. Location in patent: Paragraph 0027

2-Difluoromethyl-1H-benzoimidazole synthesis

Synthesis of 2-Difluoromethyl-1H-benzoimidazole from Ethyl difluoroacetate and o-Phenylenediamine

2-Difluoromethyl-1H-benzoimidazole Preparation Products And Raw materials

Raw materials

2-Butenoic acid, 4,4-difluoro-3-hydroxy-, methyl ester, (Z)- (9CI) Butanoic acid, 2,2-dibromo-4,4-difluoro-3-oxo-, methyl ester 2,2-DIFLUOROACETAMIDE DIFLUOROACETIC ANHYDRIDE Difluoroacetic acid

Ethyl difluoroacetate METHYL DIFLUOROACETATE (Difluoromethyl)trimethylsilane o-Phenylenediamine

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Preparation Products

2-Difluoromethyl-1H-benzoimidazole Suppliers

Global( 105)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	11728	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5661	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Hefei Hirisun Pharmatech Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 2-Difluoromethyl-1H-benzoimidazole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-13	2-Difluoromethyl-1H-benzoimidazole 705-09-9	US $3.00 / KG	1KG	98%	200KG	Career Henan Chemical Co

2-Difluoromethyl-1H-benzoimidazole
705-09-9
US $3.00 / KG
98%
Career Henan Chemical Co

2-Difluoromethyl-1H-benzoimidazole Spectrum

2-Difluoromethyl-1H-benzoimidazole(705-09-9)¹HNMR

705-09-9(2-Difluoromethyl-1H-benzoimidazole)Related Search:

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1H-benzo[d]imidazole, 2-(difluoromethyl)- 2-(Difluoromethyl) 1H-Benzimidazole,2-(difluoromethyl)-(9CI) 2-Difluoromethyl-1H-benzoimidazole 2-(difluoromethyl)-1H-benzimidazole(SALTDATA: FREE) 2-(Difluoromethyl)-1H-benzimidazole 2-(difluoroMethyl)-1H-1,3-benzodiazole 2-Difluoromethylbenzimidazole EOS-60796 1H-Benzimidazole, 2-(difluoromethyl)- Octanedioicacid,3,10-dioxo-,dimethylester 2-Benzofurancarboxylicacid,8-amino-,ethylester 705-09-9 BENZIMIDAZOLE