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ChemicalBook >> CAS DataBase List >>[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo-

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo-

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- Structure
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- structure
CAS No.
2869954-53-8
Chemical Name:
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo-
Synonyms
Werner syndrome RecQ helicase-IN-4;2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(3-hydroxypicolinoyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-methyl-4-(trifluoromethyl)phenyl)acetamide;[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo-
CBNumber:
CB712437473
Molecular Formula:
C32H33F3N8O5
Molecular Weight:
666.65
MDL Number:
MOL File:
2869954-53-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:53:25
Request For Quotation

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- Properties

Density 1.49±0.1 g/cm3(Predicted)
solubility DMSO: Sparingly soluble: 1-10 mg/ml
form Solid
pka 6.20±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 41679 Werner Syndrome RecQ Helicase-IN-4 ≥95% 2869954-53-8 5mg $439 2026-04-30 Buy
Cayman Chemical 41679 Werner Syndrome RecQ Helicase-IN-4 ≥95% 2869954-53-8 10mg $615 2026-04-30 Buy
Cayman Chemical 41679 Werner Syndrome RecQ Helicase-IN-4 ≥95% 2869954-53-8 25mg $1087 2026-04-30 Buy
Cayman Chemical 41679 Werner Syndrome RecQ Helicase-IN-4 ≥95% 2869954-53-8 50mg $1976 2026-04-30 Buy
ChemScene CS-0638478 Werner syndrome RecQ helicase-IN-4 98.13% 2869954-53-8 5mg $433 2026-06-04 Buy
Product number Packaging Price Buy
41679 5mg $439 Buy
41679 10mg $615 Buy
41679 25mg $1087 Buy
41679 50mg $1976 Buy
CS-0638478 5mg $433 Buy

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- Chemical Properties, Uses, Production

Uses

Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 μM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity[1].

in vivo

Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) shows anticancer activity in mouse[1].

Animal Model:Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)[1]
Dosage:240 mg/kg
Administration:P.o.; daily for 18 days
Result:Inhibited tumor growth.

References

[1] Vincent Bordas, et al. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060A1.
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- Preparation Products And Raw materials

Raw materials

Preparation Products

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- Suppliers

Global Suppliers ( 13)
Supplier Tel Email Country ProdList Advantage
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
LinkChem Technology Co., Ltd. 021-58950110 13124863828 sales@linkchem.cn China 2994 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 964 58
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3075 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Tingbo Chemical Technology Co., Ltd. 13564723712 22265687@qq.com China 354 58
Wuhan Acumen Bio-Technology Co.,ltd 027-027-16602739303 16602739303 673003916@qq.com China 4593 58
Changsha Fuzhen Biotechnology Co.，LTD 15111215862 18229892877 3062105966@qq.com China 5568 58
Supplier Advantage
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai SuperLan Chemcial Technique Centre 58
LinkChem Technology Co., Ltd. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Nantong Hi-Future Biotechnology Co., Ltd 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Tingbo Chemical Technology Co., Ltd. 58
Wuhan Acumen Bio-Technology Co.,ltd 58
Changsha Fuzhen Biotechnology Co.，LTD 58

View Latest Price from [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Werner syndrome RecQ helicase-IN-4 pictures 2026-08-08 Werner syndrome RecQ helicase-IN-4
2869954-53-8
 $572.00-1180.00 98.27% 10g TargetMol Chemicals Inc.

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- Spectrum

[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo-(2869954-53-8)1HNMR

2869954-53-8 ([1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo-) Related Search:

SID 487795 WRN inhibitor 8 [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- (R)-6-cyclohexyl-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-
Anti-Aging Compound Library

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[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, 2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(3-hydroxy-2-pyridinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo- Werner syndrome RecQ helicase-IN-4 2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(3-hydroxypicolinoyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-methyl-4-(trifluoromethyl)phenyl)acetamide 2869954-53-8