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6-Chloro-1-methyl-2(1H)pyridinone

6-Chloro-1-methyl-2(1H)pyridinone Structure
6-Chloro-1-methyl-2(1H)pyridinone structure
CAS No.
17228-63-6
Chemical Name:
6-Chloro-1-methyl-2(1H)pyridinone
Synonyms
6-Chloro-1-Methylpyridin-2(1H)-one;6-chloro-1-methylpyridin-2-one;6-Chloro-1-methyl-2(1H)pyridinone;6-Chloro-1-Methyl-1H-pyridin-2-one;2(1H)-Pyridinone, 6-chloro-1-Methyl-
CBNumber:
CB71243919
Molecular Formula:
C6H6ClNO
Molecular Weight:
143.57
MDL Number:
MFCD00955763
MOL File:
17228-63-6.mol
MSDS File:
SDS
Last updated:2026-05-28 02:53:26
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6-Chloro-1-methyl-2(1H)pyridinone Properties

Boiling point 269.1±33.0 °C(Predicted)
Density 1.29±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.98±0.62(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

6-Chloro-1-methyl-2(1H)pyridinone price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FC142488 6-Chloro-1-methylpyridin-2(1H)-one 17228-63-6 0.25g $295 2026-06-04 Buy
Biosynth FC142488 6-Chloro-1-methylpyridin-2(1H)-one 17228-63-6 0.5g $413 2026-06-04 Buy
Biosynth FC142488 6-Chloro-1-methylpyridin-2(1H)-one 17228-63-6 1g $590 2026-06-04 Buy
Biosynth FC142488 6-Chloro-1-methylpyridin-2(1H)-one 17228-63-6 2g $767 2026-06-04 Buy
Biosynth FC142488 6-Chloro-1-methylpyridin-2(1H)-one 17228-63-6 5g $1180 2026-06-04 Buy
Product number Packaging Price Buy
FC142488 0.25g $295 Buy
FC142488 0.5g $413 Buy
FC142488 1g $590 Buy
FC142488 2g $767 Buy
FC142488 5g $1180 Buy

6-Chloro-1-methyl-2(1H)pyridinone Chemical Properties, Uses, Production

Uses

6-Chloro-1-methylpyridin-2(1H)-one is used in preparation of substituted pyrimidinones for inhibiting the activity of SHP2.

Synthesis

6-Chloropyridn-2-ol

16879-02-0

Iodomethane

74-88-4

6-Chloro-1-methyl-2(1H)pyridinone

17228-63-6

The general procedure for the synthesis of 6-chloro-1-methylpyridin-2(1H)-one from 6-chloropyridin-2-ol and iodomethane was as follows: to a solution of 6-chloropyridin-2-ol (10.00 g, 77.19 mmol) in acetone (350 mL) was added potassium carbonate (K2CO3, 37.34 g, 270.2 mmol) and iodomethane (17.37 ml. 270.2 mmol). The reaction mixture was stirred at room temperature for 1 hour and then under reflux conditions for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered to remove the potassium carbonate and the solid was washed with acetone. The filtrate was concentrated and the residue partitioned between water (H2O) and dichloromethane (CH2Cl2). The organic and aqueous phases were separated and the aqueous phase was extracted once more with dichloromethane (1x). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give a yellow oily crude product. The crude product was purified by silica gel fast column chromatography using 10:1 dichloromethane/ethyl acetate (CH2Cl2/EtOAc) as eluent. The final target product 6-chloro-1-methylpyridin-2(1H)-one (7.38 g, 67% yield) was obtained as a white solid. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3) and LRMS (ESI pos): 1H-NMR δ 7.23 (dd, 1H), 6.50 (dd, 1H), 6.30 (m, 1H), 3.69 (s, 3H); LRMS (ESI pos) m/e 144 (M + 1).

References

[1] Heterocycles, 2000, vol. 52, # 1, p. 253 - 260
[2] Patent: WO2007/146824, 2007, A2. Location in patent: Page/Page column 126; 127
[3] Patent: WO2015/200843, A1. Location in patent: Paragraph 00179
[3] Patent: , 2015, . Location in patent: Paragraph 00179
[5] Patent: WO2012/114268, 2012, A1. Location in patent: Page/Page column 101

6-Chloro-1-methyl-2(1H)pyridinone Preparation Products And Raw materials

Raw materials

6-Chloropyridn-2-ol Iodomethane Acetone Potassium carbonate

Preparation Products

6-Chloro-1-methyl-2(1H)pyridinone Suppliers

Global Suppliers ( 27)
Supplier Tel Email Country ProdList Advantage
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
EnliPharma Technology Co., Ltd 0551-66399836 18955197623 sales@enlipharma.com China 1875 55
Hangzhou Molcore Biopharmatech Co.,Ltd 400-711-5280 86-571-81025280 sales@molcore.com China 9957 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Suzhou Nuoouman Biological Technology Co., Ltd. 15026866316 180642609@qq.com China 4966 58
Hebei Huaxing Chemical Co., Ltd 0319-6931777 13930968617 630669494@qq.com China 1096 58
Zhijiang City Zhou Yuan Yao Biological Technology Co., LTD 15671050515 2267948566@qq.com China 479 58
Yujinpharma(Tianjin) Technology Co.,Ltd. 13370351217 kungfu1217@1 kungfu1217@163.com China 7991 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Hefei Hirisun Pharmatech Co., Ltd +8615056975894 shawn@hirisunpharm.com CHINA 9897 58
Supplier Advantage
SuZhou ShiYa Biopharmaceuticals, Inc. 58
EnliPharma Technology Co., Ltd 55
Hangzhou Molcore Biopharmatech Co.,Ltd 58
Aikon International Limited 58
Suzhou Nuoouman Biological Technology Co., Ltd. 58
Hebei Huaxing Chemical Co., Ltd 58
Zhijiang City Zhou Yuan Yao Biological Technology Co., LTD 58
Yujinpharma(Tianjin) Technology Co.,Ltd. 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Hefei Hirisun Pharmatech Co., Ltd 58

17228-63-6 (6-Chloro-1-methyl-2(1H)pyridinone) Related Search:

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