clusterin
- CAS No.
- Chemical Name:
- clusterin
- Synonyms
- Clu;Msgp-2;AI893575;D14Ucla3;clusterin;40 beta-chain;40 alpha-chain;Complement cytolysis inhibitor(CLI);Recombinant Mouse Clusterin/Clu Protein, His Tag;Recombinant Human Clusterin/CLU Protein, His Tag
- CBNumber:
- CB71306674
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| FDA UNII | NEH8IKS25R |
clusterin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | C5870-01L | Clusterin PurifiedbyProteinAaffinitychromatography. | 100ug | $602 | 2026-06-03 | Buy | |
| Usbiological | 546018 | Clusterin PurifiedbyProteinAandpeptideaffinitychromatography. | 200ul | $596 | 2026-06-03 | Buy | |
| Usbiological | 546017 | Clusterin PurifiedbyProteinGaffinitychromatography. | 200ul | $559 | 2026-06-03 | Buy | |
| Usbiological | 521652 | CLU Purifiedbyimmunoaffinitychromatography. | 100ul | $736 | 2026-06-03 | Buy | |
| Usbiological | 521652 | CLU Purifiedbyimmunoaffinitychromatography. | 200ul | $944 | 2026-06-03 | Buy |
clusterin Chemical Properties, Uses, Production
Source
Plasma
Background
Clusterin also named Apolipoprotein J (APO-J) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified.
The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the a and b chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic a-helices.
Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen.
It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition.
A genuine function of clusterin has not been defined. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced insults caused by degraded and misfolded protein precipitates.
Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
clusterin Preparation Products And Raw materials
Raw materials
Preparation Products
clusterin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 9925 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Shanghai Lebeishi Biotechnology Co., LTD | 13774214275 | labex-mkt@univ-bio.com | China | 5512 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| ACROBiosystems | 13121935750 | jiaxin.zhao@acrobiosystems.com | China | 1582 | 58 |
| Aopeisai Biotechnology (Shanghai) Co., Ltd | 13061929770 | 3004391297@qq.com | China | 1780 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| shlmai | 021-67680335 13052188602 | sale1@shlmai.net | China | 10000 | 58 |
