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Ethyl N-Boc-4-methylpiperidine-4-carboxylate

Ethyl N-Boc-4-methylpiperidine-4-carboxylate structure

CAS No.: 189442-87-3

Chemical Name:: Ethyl N-Boc-4-methylpiperidine-4-carboxylate

Synonyms: ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOX&;N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLATE;N-BOC-4-METHYL ISONIPECOTIC ACID ETHYL ESTER;Ethyl 1-Boc-4-methylpiperidine-4-carboxylate;ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOXYLATE;1-Boc-4-Methyl-isonipecotic acid ethyl ester;ETHYL 1-N-BOC-4-METHYL-PIPERIDINE-CARBOXYLATE;Ethyl N-Boc-4-methylpiperidine-4-carboxylate ,97%;N-Boc-4-Methyl isonipecotic acid ethyl ester ,95%;1,4-PIPERIDINEDICARBOXYLIC ACID, 4-1-(1,1-DIMETHYL

CBNumber:: CB7133477

Molecular Formula:: C14H25NO4

Molecular Weight:: 271.35

MDL Number:: MFCD08689955

MOL File:: 189442-87-3.mol

MSDS File:: SDS

Last updated:2026-05-28 02:51:13

Product description	Number	Pack Size	Price
Ethyl N-Boc-4-methylpiperidine-4-carboxylate 97%	673927	1g	$143
1-BOC-4-METHYL-ISONIPECOTIC ACID ETHYL ESTER 97%	50832	1G	$21
1-BOC-4-METHYL-ISONIPECOTIC ACID ETHYL ESTER 97%	50832	5G	$64
Ethyl 1-Boc-4-methylpiperidine-4-carboxylate	123991	1.00g	$116
Ethyl 1-Boc-4-methylpiperidine-4-carboxylate 95+%	E14287	1g	$62
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Ethyl N-Boc-4-methylpiperidine-4-carboxylate Properties

Boiling point	329.7±35.0 °C(Predicted)
Density	1.0134 g/mL at 25 °C
refractive index	1.4554
Flash point	110 °C
storage temp.	2-8°C
pka	-2.20±0.40(Predicted)
Appearance	Colorless to light yellow Liquid
InChI	1S/C14H25NO4/c1-6-18-11(16)14(5)7-9-15(10-8-14)12(17)19-13(2,3)4/h6-10H2,1-5H3
InChIKey	ZQZVWDXMUCTNRI-UHFFFAOYSA-N
SMILES	CCOC(=O)C1(C)CCN(CC1)C(=O)OC(C)(C)C
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H301-H315-H318-H335
Precautionary statements	P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
target organs	Respiratory system
PPE	Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes	T
Risk Statements	25-37/38-41
Safety Statements	26-36/37/39-45
RIDADR	UN 2810
WGK Germany	3
HazardClass	IRRITANT
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3

Ethyl N-Boc-4-methylpiperidine-4-carboxylate price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	673927	Ethyl N-Boc-4-methylpiperidine-4-carboxylate 97%	189442-87-3	1g	$143	2023-06-20	Buy
AstaTech	50832	1-BOC-4-METHYL-ISONIPECOTIC ACID ETHYL ESTER 97%	189442-87-3	1G	$21	2026-04-30	Buy
AstaTech	50832	1-BOC-4-METHYL-ISONIPECOTIC ACID ETHYL ESTER 97%	189442-87-3	5G	$64	2026-04-30	Buy
Matrix Scientific	123991	Ethyl 1-Boc-4-methylpiperidine-4-carboxylate	189442-87-3	1.00g	$116	2026-05-18	Buy
Synthonix	E14287	Ethyl 1-Boc-4-methylpiperidine-4-carboxylate 95+%	189442-87-3	1g	$62	2026-05-06	Buy

Product number	Packaging	Price	Buy
673927	1g	$143	Buy
50832	1G	$21	Buy
50832	5G	$64	Buy
123991	1.00g	$116	Buy
E14287	1g	$62	Buy

Ethyl N-Boc-4-methylpiperidine-4-carboxylate Chemical Properties,Uses,Production

Uses

Reactant for synthesis of:

Dipeptidyl peptidase-4 inhibitor ABT-279
Building blocks for piperazine-based CCR5 antagonists

Synthesis

142851-03-4

74-88-4

Ethyl N-Boc-4-methylpiperidine-4-carboxylate

189442-87-3

Ethyl N-Boc-4-piperidinecarboxylate (10.00 g, 36.92 mmol) was dissolved in tetrahydrofuran (THF, 100 mL) and the solution was cooled to -78 °C. Under nitrogen protection, lithium diisopropylammonium (LDA, 47 mmol, 23 mL) was slowly added, maintaining the temperature at -78 °C, and the reaction mixture was stirred for 1 hour. Subsequently, iodomethane (81.25 mmol, 5.08 mL) was added dropwise and stirring was continued at -78 °C for 1 hour. Upon completion of the reaction, the cold bath was removed and the reaction mixture was allowed to warm slowly to room temperature and stirring was continued for 30 min. The reaction was quenched with saturated ammonium chloride (NH4Cl) solution followed by partition extraction with ethyl acetate (EtOAc). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product ethyl N-Boc-4-methyl-4-piperidinecarboxylate in quantitative yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6) with chemical shifts δ: 4.11 (q, J=7.1 Hz, 2H), 3.61 (dt, J=13.4 Hz, J=4.5 Hz, 2H), 2.95 (d, J=0.3 Hz, 2H), 1.91 (d, J=13.6 Hz, 2H), 1.39 (s, 9H) , 1.31 (m, 2H), 1.19 (m, 3H), 1.15 (s, 3H).

References

[1] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 113; 114
[2] Patent: WO2015/86525, 2015, A1. Location in patent: Page/Page column 117
[3] Patent: WO2008/121687, 2008, A2. Location in patent: Page/Page column 43; 89; 94
[4] Patent: WO2006/83003, 2006, A1. Location in patent: Page/Page column 36-37
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 11, p. 4680 - 4692

Ethyl N-Boc-4-methylpiperidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Ethanol Sodium sulfate Di-tert-butyl dicarbonate Triethylamine Diisopropylamine

Tetrahydrofuran Ammonium chloride Ethyl 4-piperidinecarboxylate Ethyl acetate Hydrochloric acid

Sodium bicarbonate Dichloromethane Methanol Magnesium sulfate Petroleum ether

Iodomethane Potassium bisulfate n-Butyllithium

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Preparation Products

Ethyl N-Boc-4-methylpiperidine-4-carboxylate Suppliers

Global( 118)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29095	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49859	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58
GIHI CHEMICALS CO.,LIMITED	58
HANGZHOU LEAP CHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from Ethyl N-Boc-4-methylpiperidine-4-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-08	Ethyl N-Boc-4-methylpiperidine-4-carboxylate 189442-87-3		1KG	98%； 99%	1kg; 5kg; 10kg；25kg	Career Henan Chemical Co

Ethyl N-Boc-4-methylpiperidine-4-carboxylate
189442-87-3
$0.01
98%； 99%
Career Henan Chemical Co

Ethyl N-Boc-4-methylpiperidine-4-carboxylate Spectrum

Ethyl N-Boc-4-methylpiperidine-4-carboxylate(189442-87-3)¹HNMR

189442-87-3(Ethyl N-Boc-4-methylpiperidine-4-carboxylate)Related Search:

Triacetonediamine Ethyl acetate Urethane 1,2,2,6,6-Pentamethyl-4-piperidinol tert-Butyl carbazate

Ethylparaben Ethyl cyanoacetate Ethyl acrylate Ethyl 4-piperidinecarboxylate RESMETHRIN

ISOXADIFEN-ETHYL Ethyl pyruvate Ethyl formate 4-(N-Boc-amino)phenylboronic acid pinacol ester 2,2,6,6-Tetramethyl-4-piperidinol

Ethanol Ethyl chloroformate 4-Methylpiperidine

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ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOX& 1,4-PIPERIDINEDICARBOXYLIC ACID, 4-1-(1,1-DIMETHYL 1-TERT-BUTYL 4-METHYL 4- METHYLPIPERIDINE1,4-DICARBOXYLATE N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLATEN-BOC-4-METHYL ISONIPECOTIC ACID ETHYL ESTER N-Boc-4-Methyl isonipecotic acid ethyl ester ,95% Ethyl N-Boc-4-methylpiperidine-4-carboxylate ,97% 1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxylic acid ethyl ester 4-Methyl-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester Ethyl 1-Boc-4-methylpiperidine-4-carboxylate N-BOC-4-METHYL ISONIPECOTIC ACID ETHYL ESTER N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLATE ETHYL 1-N-BOC-4-METHYL-PIPERIDINE-CARBOXYLATE ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOXYLATE 1-O-TERT-BUTYL 4-O-ETHYL 4-METHYLPIPERIDINE-1,4-DICARBOXYLATE 1-tert-butyl 4-ethyl 4-Methylpiperidine-1,4-dicarboxylate 1-Boc-4-Methyl-isonipecotic acid ethyl ester 1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) 4-ethyl ester Ethyl N-Boc-4-methylpiperidine-4-carboxylate USP/EP/BP Ethyl N-Boc-4-methylpiperidine-4-carboxylate Ethyl 1-Boc-4-methylpiperidine-4-carboxylate - [E14287] 189442-87-3 189-35-2 Piperidines Heterocyclic Building Blocks Building Blocks Building Blocks Heterocyclic Building Blocks Piperidines Heterocycles API intermediates Amino Acids and Derivatives