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2-Aminopyridine-5-boronic acid, pinacol ester

2-Aminopyridine-5-boronic acid, pinacol ester structure

CAS No.: 827614-64-2

Chemical Name:: 2-Aminopyridine-5-boronic acid, pinacol ester

Synonyms: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine;2-Aminopyridine-5-boronic acid;2-dioxaborolan-2-yl)pyridin-2-aMine;6-AMINOPYRIDINE-3-BORONIC ACID PINACOL ESTER;2-AMINOPYRIDINE-5-BORONIC ACID, PINACOL ESTER;(2-Aminopyridin-5-yl)boronic acid pinacol ester;(6-AMINOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;2-AMinopyridine-5-boronic acid pinacol ester 97%;6-Aminopyridine-3-boronic acid, pinacol ester 95%;5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

CBNumber:: CB7133659

Molecular Formula:: C11H17BN2O2

Molecular Weight:: 220.08

MDL Number:: MFCD05663837

MOL File:: 827614-64-2.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:48

Product description	Number	Pack Size	Price
2-Aminopyridine-5-boronic acid pinacol ester 97%	640379	1g	$46.15
2-Aminopyridine-5-boronic acid pinacol ester 97%	640379	5g	$123.2
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine min. 98.0 %	A3206	1G	$124
2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine	A629995	2.5g	$105
2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine	A629995	25g	$580
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2-Aminopyridine-5-boronic acid, pinacol ester Properties

Melting point	131-135 °C(lit.)
Boiling point	146°C/0.3mm
Density	1.09±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form	solid
pka	7.03±0.26(Predicted)
Appearance	Off-white to light yellow Solid
Water Solubility	Insoluble in water.
InChI	InChI=1S/C11H17BN2O2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3,(H2,13,14)
InChIKey	YFTAUNOLAHRUIE-UHFFFAOYSA-N
SMILES	C1(N)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1
CAS DataBase Reference	827614-64-2(CAS DataBase Reference)
UNSPSC Code	12352103
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

HS Code

2933399990

NFPA 704

	1
2		0

2-Aminopyridine-5-boronic acid, pinacol ester price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	640379	2-Aminopyridine-5-boronic acid pinacol ester 97%	827614-64-2	1g	$46.15	2025-07-31	Buy
Sigma-Aldrich	640379	2-Aminopyridine-5-boronic acid pinacol ester 97%	827614-64-2	5g	$123.2	2025-07-31	Buy
TCI Chemical	A3206	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine min. 98.0 %	827614-64-2	1G	$124	2025-07-31	Buy
TRC	A629995	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine	827614-64-2	2.5g	$105	2021-12-16	Buy
TRC	A629995	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine	827614-64-2	25g	$580	2021-12-16	Buy

Product number	Packaging	Price	Buy
640379	1g	$46.15	Buy
640379	5g	$123.2	Buy
A3206	1G	$124	Buy
A629995	2.5g	$105	Buy
A629995	25g	$580	Buy

2-Aminopyridine-5-boronic acid, pinacol ester Chemical Properties,Uses,Production

Uses

2-Aminopyridine-5-boronic acid, pinacol ester can be used in a microwave-assisted, four-component coupling process leading to amino substituted imidazopyridines.

Uses

It is an important raw material and intermediate. Substrate employed in a microwave-assisted, four-component coupling process leading to amino substituted imidazopyridines.

Synthesis

1072-97-5

73183-34-3

827614-64-2

General procedure for the synthesis of 2-aminopyridine-5-boronic acid pinacol ester from 2-amino-5-bromopyridine and biboronic acid pinacol ester: a 5L three-necked flask was assembled with a mechanical stirrer, and 300 g of 2-amino-5-bromopyridine, 528 g of biboronic acid pinacol ester, 3 L of 1,4-dioxane, 42.4 g of [Pd(dppf)2Cl2], and 593 g of anhydrous potassium acetate were added to it. . The reaction system was displaced three times with nitrogen to remove air, followed by heating to 80 °C and stirring the reaction for 16 hours. The progress of the reaction was monitored by TLC and after confirming the completion of the reaction, it was cooled to room temperature and diafiltrated. The filter cake was washed twice with 200 mL of dichloromethane, the filtrates were combined and concentrated to dryness. To the residue, 2 L of methanol was added and stirred at 37 °C overnight. Subsequently, 200 g of activated charcoal was added, stirred at room temperature and filtered. The filtrate was concentrated to dryness to obtain an oil. To the oily substance was added 150 mL of petroleum ether and 2 L of methyl tert-butyl ether (MTBE), pulsed overnight and filtered to give 380 g of 2-aminopyridine-5-boronic acid pinacol ester in 99% yield.

References

[1] Patent: CN102786543, 2016, B. Location in patent: Paragraph 0037-0043
[2] Patent: WO2007/124345, 2007, A2. Location in patent: Page/Page column 25-26
[3] European Journal of Organic Chemistry, 2012, # 3, p. 595 - 603
[4] Patent: US2015/239885, 2015, A1. Location in patent: Paragraph 0167; 0168
[5] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 154 - 165

2-Aminopyridine-5-boronic acid, pinacol ester Preparation Products And Raw materials

Raw materials

2-Amino-5-bromopyridine 5-Bromo-2-nitropyridine Bis(pinacolato)diboron Potassium Acetate 1,4-Dioxane

Preparation Products

2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97% 2-AMino-5-(4-trifluoroMethoxyphenyl)pyridine

2-Aminopyridine-5-boronic acid, pinacol ester Suppliers

Global( 225)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20174	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2954	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Shanghai Arbor Chemical Co., Ltd.	58
Jinan Finer Chemical Co., Ltd	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2-Aminopyridine-5-boronic acid, pinacol ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 827614-64-2	US $200.00-1.00 / KG	1KG	99%, 99.5% Sublimated	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-09-23	2-Aminopyridine-5-boronic acid, pinacol ester 827614-64-2	US $0.00-0.00 / KG	1KG	99%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2025-06-25	2-Aminopyridine-5-boronic acid, pinacol ester 827614-64-2	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd

2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
827614-64-2
US $200.00-1.00 / KG
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

2-Aminopyridine-5-boronic acid, pinacol ester
827614-64-2
US $0.00-0.00 / KG
99%
Shenzhen Nexcon Pharmatechs Ltd.

2-Aminopyridine-5-boronic acid, pinacol ester
827614-64-2
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-Aminopyridine-5-boronic acid, pinacol ester Spectrum

2-Aminopyridine-5-boronic acid, pinacol ester(827614-64-2)¹HNMR

827614-64-2(2-Aminopyridine-5-boronic acid, pinacol ester)Related Search:

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2-AMINOPYRIDINE-5-BORONIC ACID, PINACOL ESTER 2-AMINO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 6-AMINOPYRIDINE-3-BORONIC ACID PINACOL ESTER 5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YLAMINE 6-Aminopyridine-3-boronic acid pinacol ester, 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 2-Aminopyridine-5-boronic acid 2-dioxaborolan-2-yl)pyridin-2-aMine (2-Aminopyridin-5-yl)boronic acid pinacol ester 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Pyridinamine 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-aMine 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl) yridine-2-aMine 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(6-Aminopyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-AMinopyridine-5-boronic acid pinacol ester 97% 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 2-Pyridinamine,5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- (6-AMINOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER 6-Aminopyridine-3-boronic acid, pinacol ester 95% 2-Aminopyridine-5-boronic acid, pinacol ester ISO 9001：2015 REACH 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-y)pyridin-2-amine 2-Aminopyridine-5-boronic acid pinacol ester - [A12609] 827614-64-2 C11H17BN2O2 Boronate Esters Boronic Acids and Derivatives Chemical Synthesis Heteroaryl Boronate Esters Organometallic Reagents Pyridines