ChemicalBook >> CAS DataBase List >>Aurora Kinases-IN-4
Aurora Kinases-IN-4
- CAS No.
- 2877011-84-0
- Chemical Name:
- Aurora Kinases-IN-4
- Synonyms
- Aurora Kinases-IN-4;2-Propenamide, N-[4-[7-(4-methyl-1-piperazinyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-quinazolinyl]phenyl]-
- CBNumber:
- CB714133670
- Molecular Formula:
- C26H28N8O
- Molecular Weight:
- 468.55
- MDL Number:
- MOL File:
- 2877011-84-0.mol
Last updated:2025-05-19 13:47:43
Aurora Kinases-IN-4 Chemical Properties,Uses,Production
Uses
Aurora kinase-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora kinase-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora kinase-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].
References
[1] Zhang B, et al. Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer. Eur J Med Chem. 2023 Aug 5;256:115457. DOI:10.1016/j.ejmech.2023.115457
Aurora Kinases-IN-4 Preparation Products And Raw materials
Raw materials
Preparation Products
Aurora Kinases-IN-4 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19905 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19989 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from Aurora Kinases-IN-4 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | Aurora Kinases-IN-4
2877011-84-0
|
US $1670.00-2800.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Aurora Kinases-IN-4
2877011-84-0
- US $1670.00-2800.00 / mg
- TargetMol Chemicals Inc.
Aurora Kinases-IN-4
2-Propenamide, N-[4-[7-(4-methyl-1-piperazinyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-quinazolinyl]phenyl]-
2877011-84-0