1-EBIO
- CAS No.
- 10045-45-1
- Chemical Name:
- 1-EBIO
- Synonyms
- EBIO;1-EB10;1-EBIO;Einecs 233-148-1;1-EBIO, 10 mM in DMSO;1-EthylbenziMidazolinone;1-ETHYL-2-BENZIMIDAZOLINONE;1-ethylbenzimidazolin-2-one;1-ETHYL-2-BENZCMIDAZOLINONE;1-Ethyl-2-benzimidazolineone
- CBNumber:
- CB7146587
- Molecular Formula:
- C9H10N2O
- Molecular Weight:
- 162.19
- MDL Number:
- MFCD00005715
- MOL File:
- 10045-45-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-EBIO ≥98% (HPLC) | SML0034 | 10mg | $111 |
| 1-EBIO ≥98% (HPLC) | SML0034 | 50mg | $445 |
| 1-EBIO ≥98% | 14575 | 5mg | $36 |
| 1-EBIO ≥98% | 14575 | 10mg | $55 |
| 1-EBIO ≥98% | 14575 | 50mg | $213 |
| Melting point | 118-120 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Density | 1.161±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: ≥20mg/mL |
| pka | 12.29±0.30(Predicted) |
| form | powder |
| color | Crystalline |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| FDA UNII | M82W79SS4W |
1-EBIO price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0034 | 1-EBIO ≥98% (HPLC) | 10045-45-1 | 10mg | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0034 | 1-EBIO ≥98% (HPLC) | 10045-45-1 | 50mg | $445 | 2026-04-30 | Buy |
| Cayman Chemical | 14575 | 1-EBIO ≥98% | 10045-45-1 | 5mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 14575 | 1-EBIO ≥98% | 10045-45-1 | 10mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 14575 | 1-EBIO ≥98% | 10045-45-1 | 50mg | $213 | 2026-04-30 | Buy |
1-EBIO Chemical Properties,Uses,Production
Description
1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.
Uses
1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
Definition
ChEBI: 1-Ethyl-2-benzimidazolinone is a member of imidazoles.
Biological Activity
Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells.
storage
Room temperature
References
[1] ADEAGBO A S O. 1-Ethyl-2-benzimidazolinone stimulates endothelial KCa channels and nitric oxide formation in rat mesenteric vessels[J]. European journal of pharmacology, 1999, 379 2: Pages 151-159. DOI:10.1016/s0014-2999(99)00489-6
[2] J. E. ORFILA. Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation[J]. European Journal of Neuroscience, 2014, 40 8: 3179-3188. DOI:10.1111/ejn.12683
[3] DUANE ALLEN. SK2 channels are neuroprotective for ischemia-induced neuronal cell death.[J]. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011: 2302-2312. DOI:10.1038/jcbfm.2011.90
[4] MARTIN MÜLLER. Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men.[J]. Stem Cell Reviews and Reports, 2012: 720-740. DOI:10.1007/s12015-011-9324-9
[5] ALEX J FAY. SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 17548-17553. DOI:10.1073/pnas.0607914103
1-EBIO Preparation Products And Raw materials
1-EBIO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9539 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9922 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53802 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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