ChemicalBook >> CAS DataBase List >>(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE structure

CAS No.: 189028-95-3

Chemical Name:: (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

Synonyms: (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one;ZT-5;idin-2-one;Ezetimibe-003;Ezetimibe INT A;(S)-3-((S)-5-(4-FL;-5-(4-Fluorophenyl);-5-hydroxypentanoyl);)-5-hydroxypentanoyL;Ezetimibe Impurity 45

CBNumber:: CB71473325

Molecular Formula:: C20H20FNO4

Molecular Weight:: 357.38

MDL Number:: MFCD13194798

MOL File:: 189028-95-3.mol

MSDS File:: SDS

Last updated:2026-05-28 02:19:47

Product description	Number	Pack Size	Price
3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one	423438	500mg	$403
3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one	423438	5g	$1776
(S)-3((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one	FF57617	2g	$900
(S)-3((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one	FF57617	25g	$900
(S)-3((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one	FF57617	10g	$900
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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Properties

Boiling point	572.7±50.0 °C(Predicted)
Density	1.297
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	14.17±0.20(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1S/C20H20FNO4/c21-16-11-9-15(10-12-16)18(23)7-4-8-19(24)22-17(13-26-20(22)25)14-5-2-1-3-6-14/h1-3,5-6,9-12,17-18,23H,4,7-8,13H2/t17-,18+/m1/s1
InChIKey	AVAZNWOHQJYCEL-MSOLQXFVSA-N
SMILES	O1C[C@H](C2=CC=CC=C2)N(C(=O)CCC[C@@H](C2=CC=C(F)C=C2)O)C1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	423438	3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one	189028-95-3	500mg	$403	2026-06-03	Buy
Usbiological	423438	3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one	189028-95-3	5g	$1776	2026-06-03	Buy
Biosynth	FF57617	(S)-3((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one	189028-95-3	2g	$900	2026-06-04	Buy
Biosynth	FF57617	(S)-3((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one	189028-95-3	25g	$900	2026-06-04	Buy
Biosynth	FF57617	(S)-3((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one	189028-95-3	10g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
423438	500mg	$403	Buy
423438	5g	$1776	Buy
FF57617	2g	$900	Buy
FF57617	25g	$900	Buy
FF57617	10g	$900	Buy

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Chemical Properties,Uses,Production

Description

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1, 3-OXAZOLIDIN-2-ONE is a derivative of 2-oxazolidine, which is an effective antimicrobial. It can be used as a pharmaceutical intermediate for the preparation of ezetimibe which is a drug used to lower the patients’ plasma cholesterol levels.

Chemical Properties

Solid

Uses

3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

Synthesis

A process for synthesis of (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE comprising of resolution of 4S- phenyl -3-[(5RS)-5-(4-fluorophenyl)-5-hydroxypentanoyl] -1,3 oxazolidin 2-one by selective esterification of 4S-phenyl -3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl] -1,3 oxazolidin 2-one using appropriate esterification reagent in an organic solvent in presence of Lipase enzyme at a temperature ranging from 0° to 100°C, and further isolation.

References

http://www.cphi-online.com/ezetimibe-intermediate-4s3-prod587443.html
https://en.wikipedia.org/wiki/2-Oxazolidone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE synthesis

Synthesis of (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE from (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Suppliers

Global( 276)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	+8613681683526	lchen@syncozymes.com	China	286	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58

Supplier	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	58
Capot Chemical Co.,Ltd.	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Yingrui Biopharma Co., Ltd.	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58

(4S)- 3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-pheny-1,3-oxazolidin-2-one : Biosynthesis, Optimization of biosynthesis conditions And Influencing factors Studies
The (4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-pheny-1,3-oxazolidin-2-one,?is an chiral intermediate in the synthes....
Jan 18，2023

View Lastest Price from (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-12	(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3	$1.00	1KG	99%+	10000KG	Shaanxi Dideu Medichem Co. Ltd
2025-04-04	(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-12-22	(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3	$10.00	1KG	98%	500ton/Month	Qiuxian Baitai New Material Co., LTD

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
189028-95-3
$1.00
99%+
Shaanxi Dideu Medichem Co. Ltd

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
189028-95-3
98%
Henan Aochuang Chemical Co.,Ltd.

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
189028-95-3
$10.00
98%
Qiuxian Baitai New Material Co., LTD

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Spectrum

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE(189028-95-3)¹HNMR

189028-95-3((4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE)Related Search:

5-(4-FLUOROPHENYL)VALERIC ACID Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate (4S,5R)-5-[3,5-bis(triflu... 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone (3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid

3-O-Acetyl Ezetimibe ent-EzetiMibe EzetiMibe LactaM Cleaved Alcohol Dextran 4-(4-Fluorobenzoyl)butyric acid

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Ezetimibe 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Flupirtine maleate PD 0332991 HCl

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE (4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxo-pentyl]-4-phenyl-2-Oxazolidinone EzetiMibe InterMediates 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- 2-Oxazolidinone Ezetimibe INT A ZT-5 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl- (4S)-3-[(5R)-5-(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-pheny-1,3-oxzolidin-2-One 2-Oxazolidinone, 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- -5-(4-Fluorophenyl) -5-hydroxypentanoyl) (S)-3-[(S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-2-oxazolidinone Ezetimibe Impurity 45 Ezetimibe-003 Ezetimibe Impurity 51 3-[5-(4-fluoro- phenyl)-5-hydroxy- pentanoyl]-5-phenyl- oxazolidin-2-one 3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one (S)-3-((S)-5-(4-FL idin-2-one )-5-hydroxypentanoyL (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONEENYL-2-OXAZOLIDINONE (4S)-3-[(5S)-5-(3-fluorophenyl)-5- hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL... Ezetimibe Impuriry 51 Ezetimibe intermediate D 189028-95-3 (4S)-3-[(5S)-5-(3-FLUOROPHENYL)-5- 3-[(5S)-5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4(S)-phenyl-2-oxazolidinone (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxyvaleryl] -4-phenyl-1,3-oxyazacyclopentane-2-one (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxypentanoyl] -4-phenyl-1,3-oxazole-2-one (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one, 99%min (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one 189028-95-3 Ezetimibe Ezetimibe intermediates 189028-95-3