Edoxaban Impurity 97 (Mixture of Diastereomers)

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Edoxaban S-Oxide (1R,3R,4R)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester N1-(5-chloropyridin-2-yl)-N2- ((1S,2R,4S)-2-[(tert- Butoxycarbonyl)Amino ]-4- [(dimethylamino)carbonyl]- cyclohexyl) oxalamide dimethanesulfonate Edoxaban Impurity 109

Edoxaban Impurity 51 Edoxaban Impurity 46 Oxalate 4,5,6,7-tetrahydro-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid Edoxaban Impurity 77 Edoxaban Impurity 41

Edoxaban Impurity 60 (p-Toluenesulfonic acid) Edoxaban Impurity 88 (1S,3R,4S) HCl (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester Edoxaban M6 Acetic acid, 2-[[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]amino]-2-oxo-, ethyl ester