5-BROMO-1-METHYL-1H-INDAZOLE
- CAS No.
- 465529-57-1
- Chemical Name:
- 5-BROMO-1-METHYL-1H-INDAZOLE
- Synonyms
- 1H-INDAZOLE, 5-BROMO-1-METHYL-;SW-5;SWF-5;Orforglipron impurity 27;5-BROMO-1-METHYLINDAZOLE;1-Methyl-5-bromoindazole;1-Methyl-5-bromo-1H-indazole;5-Bromo-1-mehtyl-1H-indazole;5-BROMO-1-METHYL-1H-INDAZOLE;5-bromo-1-methyl-1H-indazole, N1-methyl-5-bromoindazole, 5-bromo-1-methylindazole, 5-bromo-1-methyl-1H-indazole, 5-Brom-1-methyl-1H-indazol, N-1-methyl-5-bromoindazole
- CBNumber:
- CB71499813
- Molecular Formula:
- C8H7BrN2
- Molecular Weight:
- 211.06
- MDL Number:
- MFCD09878568
- MOL File:
- 465529-57-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-1-methyl-1H-indazole 98% | AS50370 | 5g | $31 |
| 5-Bromo-1-methyl-1H-indazole 98% | AS50370 | 25g | $95 |
| 5-Bromo-1-methyl-1H-indazole 98% | AS50370 | 100g | $296 |
| 5-Bromo-1-methyl-1H-indazole 98% | OR43558 | 1g | $21 |
| 1-Methyl-5-bromoindazole ≥96%(LCMS) | 26317 | 100MG | $67.6 |
| More product size | |||
| Melting point | 111-112 °C(Solv: ligroine (8032-32-4)) |
|---|---|
| Boiling point | 293.6±13.0 °C(Predicted) |
| Density | 1.60±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | 0.36±0.30(Predicted) |
| color | Orange |
| InChI | InChI=1S/C8H7BrN2/c1-11-8-3-2-7(9)4-6(8)5-10-11/h2-5H,1H3 |
| InChIKey | RMCHMXPTUMFFBZ-UHFFFAOYSA-N |
| SMILES | N1(C)C2=C(C=C(Br)C=C2)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2933998090 |
5-BROMO-1-METHYL-1H-INDAZOLE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS50370 | 5-Bromo-1-methyl-1H-indazole 98% | 465529-57-1 | 5g | $31 | 2026-06-04 | Buy |
| Activate Scientific | AS50370 | 5-Bromo-1-methyl-1H-indazole 98% | 465529-57-1 | 25g | $95 | 2026-06-04 | Buy |
| Activate Scientific | AS50370 | 5-Bromo-1-methyl-1H-indazole 98% | 465529-57-1 | 100g | $296 | 2026-06-04 | Buy |
| Apolloscientific | OR43558 | 5-Bromo-1-methyl-1H-indazole 98% | 465529-57-1 | 1g | $21 | 2026-06-04 | Buy |
| Chem-Impex | 26317 | 1-Methyl-5-bromoindazole ≥96%(LCMS) | 465529-57-1 | 100MG | $67.6 | 2026-05-19 | Buy |
5-BROMO-1-METHYL-1H-INDAZOLE Chemical Properties,Uses,Production
Uses
5-Bromo-1-methyl-1H-indazole is an antibacterial drugs with inhibitory activity against multidrug-resistant (MDR) pathogens.
Synthesis
53857-57-1
74-88-4
465529-56-0
465529-57-1
5-Bromoindazole (590 mg, 2.99 mmol) was dissolved in tetrahydrofuran (10 mL) and stirred under ice bath conditions and sodium hydride (180 mg, 80% dispersed in mineral oil, 6.00 mmol) was added slowly. After stirring for 30 minutes, iodomethane (468 mg, 3.30 mmol) was added and stirring was continued for 3 hours. After completion of the reaction, the reaction mixture was warmed to room temperature and the reaction was quenched by the addition of water (20 mL). The reaction was extracted with ethyl acetate (20 mL × 3), and the organic phases were combined and washed with saturated saline (50 mL × 3). The organic phase was dried with anhydrous sodium sulfate, filtered and the solvent was removed by rotary evaporation. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 3:1) to afford 5-bromo-2-methyl-2H-indazole (A14-2, 230 mg, 36%) and 1-methyl-5-bromo-1H-indazole (A14-3, 330 mg, 52%).A14-2 was an off-white solid, 1H NMR (400 MHz, DMSO ) δ 8.33 (s, 1H), 7.96-7.95 (m, 1H), 7.57 (d, J = 9.2 Hz, 1H), 7.31-7.28 (m, 1H), 4.16 (s, 3H).A14-3 is a white solid.
References
[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0131; 0132; 0133; 0134; 0135
[2] Journal of Organic Chemistry, 2018, vol. 83, # 12, p. 6334 - 6353
[3] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 60-61
[4] Patent: WO2011/20861, 2011, A1. Location in patent: Page/Page column 59
[5] Chemische Berichte, 1922, vol. 55, p. 1141,1157
5-BROMO-1-METHYL-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159; +undefined+undefined18918657159 | sales@lianhe-aigen.com | China | 300 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 5-BROMO-1-METHYL-1H-INDAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 5-BROMO-1-METHYL-1H-INDAZOLE
465529-57-1
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 5-BROMO-1-METHYL-1H-INDAZOLE
465529-57-1
- $8.80
- 97%-99%
- Career Henan Chemical Co
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